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Articles (28)
American Association for the Advancement of Science (22)
Springer Nature (5)
American Association for the Advancement of Science (AAAS) (1)
Mineralogical Society of America
Scientific Reports. 2018; 8(1): Published 2018 Oct 18. doi: 10.1038/s41598-018-33579-5. (1)
Scientific Reports. 2020; 10(1): 1168. Published 2020 Jan 24. doi: 10.1038/s41598-020-57766-5. (1)
Scientific Reports. 2020; 10(1): 12799. Published 2020 Jul 30. doi: 10.1038/s41598-020-69635-2. (1)
Scientific Reports. 2020; 10(1): 1931. Published 2020 Feb 06. doi: 10.1038/s41598-020-58531-4. (1)
Scientific Reports. 2021; 11(1): 6302. Published 2021 Mar 18. doi: 10.1038/s41598-021-85859-2. (1)
Science (1)
Science. 1910; 32(819): 336-338. Published 1910 Sep 09. doi: 10.1126/science.32.819.336. (1)
Science. 1922; 55(1430): 574-575. Published 1922 May 26. doi: 10.1126/science.55.1430.574. (1)
Science. 1924; 59(1518): 103-104. Published 1924 Feb 01. doi: 10.1126/science.59.1518.103.b. (1)
Science. 1924; 59(1520): 172-172. Published 1924 Feb 15. doi: 10.1126/science.59.1520.172. (1)
Science. 1931; 73(1881): 54-59. Published 1931 Jan 16. doi: 10.1126/science.73.1881.54. (1)
Science. 1943; 97(2530): 586-587. Published 1943 Jun 25. doi: 10.1126/science.97.2530.586. (1)
Science. 1955; 121(3152): 765-766. Published 1955 May 27. doi: 10.1126/science.121.3152.765-c. (1)
Science. 1955; 121(3152): 765-766. Published 1955 May 27. doi: 10.1126/science.121.3152.765.c. (1)
Science. 1962; 138(3536): 31-32. Published 1962 Oct 05. doi: 10.1126/science.138.3536.31. (1)
Science. 1966; 151(3707): 206-208. Published 1966 Jan 14. doi: 10.1126/science.151.3707.206. (1)
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Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq (2018)

Filbin, M. G., Tirosh, I., Hovestadt, V., Shaw, M. L., Escalante, L. E., Mathewson, N. D., Neftel, C., Frank, N., Pelton, K., Hebert, C. M., Haberler, C., Yizhak, K., Gojo, J., Egervari, K., Mount, C., van Galen, P., Bonal, D. M., Nguyen, Q.-D., Beck, A., Sinai, C., Czech, T., Dorfer, C., Goumnerova, L., Lavarino, C., Carcaboso, A. M., Mora, J., Mylvaganam, R., Luo, C. C., Peyrl, A., Popovic, M., Azizi, A., Batchelor, T. T., Frosch, M. P., Martinez-Lage, M., Kieran, M. W., Bandopadhayay, P., Beroukhim, R., Fritsch, G., Getz, G., Rozenblatt-Rosen, O., Wucherpfennig, K. W., Louis, D. N., Monje, M., Slavc, I., Ligon, K. L., Golub, T. R., Regev, A., Bernstein, B. E., Suva, M. L.

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018-04-20

Description: Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary H3K27M-glioma and matched models. We found that H3K27M-glioma primarily contain cells that resemble oligodendrocyte precursor cells (OPC-like), whereas more differentiated malignant cells are a minority. OPC-like cells exhibit greater proliferation and tumor-propagating potential than their more differentiated counterparts and are at least in part sustained by PDGFRA signaling. Our study characterizes oncogenic and developmental programs in H3K27M-glioma at single-cell resolution and across genetic subclones, suggesting potential therapeutic targets in this disease.

Keywords: Genetics, Medicine, Diseases

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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Rapid fragmentation of microplastics by the freshwater amphipod Gammarus duebeni (Lillj.) (2020)

Mateos-Cárdenas, Alicia ; O’Halloran, John ; van Pelt, Frank N. A. M. ; [et al.]

Springer Nature

In: Scientific Reports. 2020; 10(1): 12799. Published 2020 Jul 30. doi: 10.1038/s41598-020-69635-2.

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Publication Date: 2020-07-30

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

Published by Springer Nature

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A combined Far-FTIR, FTIR Spectromicroscopy, and DFT Study of the Effect of DNA Binding on the [4Fe4S] Cluster Site in EndoIII (2020)

Hassan, Ayaz ; Macedo, Lucyano J. A. ; Souza, João C. P. de ; [et al.]

Springer Nature

In: Scientific Reports. 2020; 10(1): 1931. Published 2020 Feb 06. doi: 10.1038/s41598-020-58531-4.

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Publication Date: 2020-02-06

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

Published by Springer Nature

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Parkinson patients without tremor show changed patterns of mechanical muscle oscillations during a specific bilateral motor task compared to controls (2020)

Schaefer, Laura V. ; Bittmann, Frank N.

Springer Nature

In: Scientific Reports. 2020; 10(1): 1168. Published 2020 Jan 24. doi: 10.1038/s41598-020-57766-5.

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Publication Date: 2020-01-24

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

Published by Springer Nature

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Coherent behavior of neuromuscular oscillations between isometrically interacting subjects: experimental study utilizing wavelet coherence analysis of mechanomyographic and mechanotendographic signals (2018)

Schaefer, Laura V. ; Bittmann, Frank N.

Springer Nature

In: Scientific Reports. 2018; 8(1): Published 2018 Oct 18. doi: 10.1038/s41598-018-33579-5.

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Publication Date: 2018-10-18

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

Published by Springer Nature

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Acute liver injury following acetaminophen administration does not activate atrophic pathways in the mouse diaphragm (2021)

Bruells, C. S. ; Duschner, P. ; Marx, G. ; [et al.]

Springer Nature

In: Scientific Reports. 2021; 11(1): 6302. Published 2021 Mar 18. doi: 10.1038/s41598-021-85859-2.

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Publication Date: 2021-03-18

Description: N-acetyl-para-amino phenol (APAP, usually named paracetamol), which is commonly used for its analgesic and antipyretic properties may lead to hepatotoxicity and acute liver damage in case of overdoses. Released cytokines and oxidative stress following acute liver damage may affect other organs’ function notably the diaphragm, which is particularly sensitive to oxidative stress and circulating cytokines. We addressed this issue in a mouse model of acute liver injury induced by administration of APAP. C57BL/6J mice (each n = 8) were treated with N-acetyl-para-amino phenol (APAP) to induce acute drug caused liver injury and sacrificed 12 or 24 h afterwards. An untreated group served as controls. Key markers of inflammation, proteolysis, autophagy and oxidative stress were measured in diaphragm samples. In APAP treated animals, liver damage was proven by the enhanced serum levels of alanine aminotransferase and aspartate aminotransferase. In the diaphragm, besides a significant increase in IL 6 and lipid peroxidation, no changes were observed in key markers of the proteolytic, and autophagy signaling pathways, other inflammatory markers and fiber dimensions. The first 24 h of acute liver damage did not impair diaphragm atrophic pathways although it slightly enhanced IL-6 and lipid peroxidation. Whether longer exposure might affect the diaphragm needs to be addressed in future experiments.

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

Published by Springer Nature

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