Publication Date:
2016-03-02
Description:
Article Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3. Nature Communications doi: 10.1038/ncomms10782 Authors: Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García-Cáceres, Sonja C. Schriever, Veronica Casquero García, Adam Fiseha Kebede, Esther Fuente-Martin, Chitrang Trivedi, Kristy Heppner, N. Henriette Uhlenhaut, Beata Legutko, Uma D. Kabra, Yuanqing Gao, Chun-Xia Yi, Carmelo Quarta, Christoffer Clemmensen, Brian Finan, Timo D. Müller, Carola W. Meyer, Marcelo Paez-Pereda, Kerstin Stemmer, Stephen C. Woods, Diego Perez-Tilve, Robert Schneider, Eric N. Olson, Matthias H. Tschöp, Paul T. Pfluger
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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