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Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers (2018)

R. Kumar; L. Coronel; B. Somalanka; A. Raju; O. A. Aning; O. An; Y. S. Ho; S. Chen; S. Y. Mak; P. Y. Hor; H. Yang; M. Lakshmanan; H. Itoh; S. Y. Tan; Y. K. Lim; A. P. C. Wong; S. H. Chew; T. H. Huynh; B. C. Goh; C. Y. Lim; V. Tergaonkar; C. F. Cheok

Springer Nature

In: Nature Communications

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Publication Date: 2018-09-27

Description: Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers, Published online: 26 September 2018; doi:10.1038/s41467-018-05805-1 Several challenges are involved in direct targeting of mutant p53, while targeting altered fitness of cells with loss of wild type p53 is an alternative approach. Here they identify niclosamide to be selectively toxic to p53 deficient cells through a previously unknown mitochondrial uncoupling mechanism.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Author Correction: Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells (2018)

Fehlings, M. ; Simoni, Y. ; Penny, H. L. ; [et al.]

Springer Nature

In: Nature Communications. 2018; 9(1): 3000. Published 2018 Jul 26. doi: 10.1038/s41467-018-05468-y.

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Publication Date: 2018-07-26

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells (2017)

Fehlings, M. ; Simoni, Y. ; Penny, H. L. ; [et al.]

Springer Nature

In: Nature Communications. 2017; 8(1): 562. Published 2017 Sep 15. doi: 10.1038/s41467-017-00627-z.

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Publication Date: 2017-09-15

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Impermeable barrier films and protective coatings based on reduced graphene oxide (2014)

Su, Y. ; Kravets, V. G. ; Wong, S. L. ; [et al.]

Springer Nature

In: Nature Communications. 2014; 5(1): 4843. Published 2014 Sep 11. doi: 10.1038/ncomms5843.

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Publication Date: 2014-09-11

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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