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A thermally activated and highly miscible dopant for n-type organic thermoelectrics (2020)

Yang, Chi-Yuan ; Ding, Yi-Fan ; Huang, Dazhen ; [et al.]

Springer Nature

In: Nature Communications. 2020; 11(1): 3292. Published 2020 Jul 03. doi: 10.1038/s41467-020-17063-1.

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Publication Date: 2020-07-03

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Ti-substituted tunnel-type Na0.44MnO2 oxide as a negative electrode for aqueous sodium-ion batteries (2015)

Yuesheng Wang; Jue Liu; Byungju Lee; Ruimin Qiao; Zhenzhong Yang; Shuyin Xu; Xiqian Yu; Lin Gu; Yong-Sheng Hu; Wanli Yang; Kisuk Kang; Hong Li; Xiao-Qing Yang; Liquan Chen; Xuejie Huang

Springer Nature

In: Nature Communications

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Publication Date: 2015-03-27

Description: Article Aqueous sodium-ion batteries could be a potential solution for large-scale energy storage, but the conventional negative electrodes are not efficient. Here, the authors report a titanium-substituted tunnel-type Na 0.44 MnO 2 material as a promising negative electrode for aqueous sodium-ion batteries. Nature Communications doi: 10.1038/ncomms7401 Authors: Yuesheng Wang, Jue Liu, Byungju Lee, Ruimin Qiao, Zhenzhong Yang, Shuyin Xu, Xiqian Yu, Lin Gu, Yong-Sheng Hu, Wanli Yang, Kisuk Kang, Hong Li, Xiao-Qing Yang, Liquan Chen, Xuejie Huang

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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The nucleotide pGpp acts as a third alarmone in Bacillus, with functions distinct from those of (p) ppGpp (2020)

Yang, Jin ; Anderson, Brent W. ; Turdiev, Asan ; [et al.]

Springer Nature

In: Nature Communications. 2020; 11(1): 5388. Published 2020 Oct 23. doi: 10.1038/s41467-020-19166-1.

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Publication Date: 2020-10-23

Description: The alarmone nucleotides guanosine tetraphosphate and pentaphosphate, commonly referred to as (p)ppGpp, regulate bacterial responses to nutritional and other stresses. There is evidence for potential existence of a third alarmone, guanosine-5′-monophosphate-3′-diphosphate (pGpp), with less-clear functions. Here, we demonstrate the presence of pGpp in bacterial cells, and perform a comprehensive screening to identify proteins that interact respectively with pGpp, ppGpp and pppGpp in Bacillus species. Both ppGpp and pppGpp interact with proteins involved in inhibition of purine nucleotide biosynthesis and with GTPases that control ribosome assembly or activity. By contrast, pGpp interacts with purine biosynthesis proteins but not with the GTPases. In addition, we show that hydrolase NahA (also known as YvcI) efficiently produces pGpp by hydrolyzing (p)ppGpp, thus modulating alarmone composition and function. Deletion of nahA leads to reduction of pGpp levels, increased (p)ppGpp levels, slower growth recovery from nutrient downshift, and loss of competitive fitness. Our results support the existence and physiological relevance of pGpp as a third alarmone, with functions that can be distinct from those of (p)ppGpp.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors (2020)

Wang, Jue Xiang ; Irvine, Mark W. ; Burnell, Erica S. ; [et al.]

Springer Nature

In: Nature Communications. 2020; 11(1): 423. Published 2020 Jan 22. doi: 10.1038/s41467-020-14321-0.

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Publication Date: 2020-01-22

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2 (2019)

Dong, Jiangqing ; Du, Ximing ; Wang, Huan ; [et al.]

Springer Nature

In: Nature Communications. 2019; 10(1): 829. Published 2019 Feb 19. doi: 10.1038/s41467-019-08791-0.

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Publication Date: 2019-02-19

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Structural insight into the mechanism of synergistic autoinhibition of SAD kinases (2015)

Wu, Jing-Xiang ; Cheng, Yun-Sheng ; Wang, Jue ; [et al.]

Springer Nature

In: Nature Communications. 2015; 6(1): 8953. Published 2015 Dec 01. doi: 10.1038/ncomms9953.

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Publication Date: 2015-12-01

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders (2018)

Xiao, Yao ; Wang, Can ; Chen, Jia-Yu ; [et al.]

Springer Nature

In: Nature Communications. 2018; 9(1): 2015. Published 2018 May 22. doi: 10.1038/s41467-018-04352-z.

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Publication Date: 2018-05-22

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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