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Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors (2014)

Anna A. Marusiak; Zoe C. Edwards; Willy Hugo; Eleanor W. Trotter; Maria R. Girotti; Natalie L. Stephenson; Xiangju Kong; Michael G. Gartside; Shameem Fawdar; Andrew Hudson; Wolfgang Breitwieser; Nicholas K. Hayward; Richard Marais; Roger S. Lo; John Brognard

Springer Nature

In: Nature Communications

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Publication Date: 2014-05-24

Description: Article B-Raf is mutated in many melanomas but treatment of the disease with small molecules targeting the mutant protein often results in tumour resistance. Here, the authors show that mixed lineage kinases (MLK1-4) can reactivate the B-Raf signalling pathway in the presence of inhibitors, resulting in drug resistance. Nature Communications doi: 10.1038/ncomms4901 Authors: Anna A. Marusiak, Zoe C. Edwards, Willy Hugo, Eleanor W. Trotter, Maria R. Girotti, Natalie L. Stephenson, Xiangju Kong, Michael G. Gartside, Shameem Fawdar, Andrew Hudson, Wolfgang Breitwieser, Nicholas K. Hayward, Richard Marais, Roger S. Lo, John Brognard

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics (2014)

Benjamin H. Rotstein; Nickeisha A. Stephenson; Neil Vasdev; Steven H. Liang

Springer Nature

In: Nature Communications

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Publication Date: 2014-07-11

Description: Article Fluorine-18 containing molecules are important for PET imaging, but due to the short half-life it is necessary to develop rapid methods for its introduction. Here, the authors use spirocyclic iodine(III) precursors, allowing direct 18F labelling of highly functionalized non-activated arenes and PET radiopharmaceuticals. Nature Communications doi: 10.1038/ncomms5365 Authors: Benjamin H. Rotstein, Nickeisha A. Stephenson, Neil Vasdev, Steven H. Liang

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Atomically resolved tomography to directly inform simulations for structure–property relationships (2014)

Michael P. Moody; Anna V. Ceguerra; Andrew J. Breen; Xiang Yuan Cui; Baptiste Gault; Leigh T. Stephenson; Ross K. W. Marceau; Rebecca C. Powles; Simon P. Ringer

Springer Nature

In: Nature Communications

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Publication Date: 2014-11-21

Description: Article Atom probe tomography is known to be an important tool for probing atomic-scale chemical distribution in various materials. Now, Moody and colleagues demonstrate an approach by which atom probe data can be used to directly inform first-principles calculations, for the determination of local properties. Nature Communications doi: 10.1038/ncomms6501 Authors: Michael P. Moody, Anna V. Ceguerra, Andrew J. Breen, Xiang Yuan Cui, Baptiste Gault, Leigh T. Stephenson, Ross K. W. Marceau, Rebecca C. Powles, Simon P. Ringer

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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