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The structure and substrate specificity of human Cdk12/Cyclin K (2014)

Christian A. Bösken; Lucas Farnung; Corinna Hintermair; Miriam Merzel Schachter; Karin Vogel-Bachmayr; Dalibor Blazek; Kanchan Anand; Robert P. Fisher; Dirk Eick; Matthias Geyer

Springer Nature

In: Nature Communications

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Publication Date: 2014-03-26

Description: Article Cyclin-dependent kinase 12 (Cdk12) phosphorylates the C-terminal domain (CTD) of RNA polymerase II to regulate transcription. Here, the authors solve the crystal structure of the Cdk12 kinase domain and show that Cdk12 has its highest activity on a CTD substrate that carries a serine 7 phosphorylation. Nature Communications doi: 10.1038/ncomms4505 Authors: Christian A. Bösken, Lucas Farnung, Corinna Hintermair, Miriam Merzel Schachter, Karin Vogel-Bachmayr, Dalibor Blazek, Kanchan Anand, Robert P. Fisher, Dirk Eick, Matthias Geyer

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity (2014)

Thomas Vogl; Michel Eisenblätter; Tom Völler; Stefanie Zenker; Sven Hermann; Peter van Lent; Andreas Faust; Christiane Geyer; Beatrix Petersen; Kirsten Roebrock; Michael Schäfers; Christoph Bremer; Johannes Roth

Springer Nature

In: Nature Communications

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Publication Date: 2014-08-08

Description: Article Alarmins are locally released during inflammation and are early amplifiers of inflammation. Here Vogl et al. show that the alarmin S100A8/S100A9 can be used as a sensitive marker to detect subclinical inflammation and follow disease progression in a variety of disease models. Nature Communications doi: 10.1038/ncomms5593 Authors: Thomas Vogl, Michel Eisenblätter, Tom Völler, Stefanie Zenker, Sven Hermann, Peter van Lent, Andreas Faust, Christiane Geyer, Beatrix Petersen, Kirsten Roebrock, Michael Schäfers, Christoph Bremer, Johannes Roth

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity (2014)

Vogl, Thomas ; Eisenblätter, Michel ; Völler, Tom ; [et al.]

Springer Nature

In: Nature Communications. 2014; 5(1): 4593. Published 2014 Aug 06. doi: 10.1038/ncomms5593.

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Publication Date: 2014-08-06

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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The structure and substrate specificity of human Cdk12/Cyclin K (2014)

Bösken, Christian A. ; Farnung, Lucas ; Hintermair, Corinna ; [et al.]

Springer Nature

In: Nature Communications. 2014; 5(1): 3505. Published 2014 Mar 24. doi: 10.1038/ncomms4505.

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Publication Date: 2014-03-24

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Adhesive water networks facilitate binding of protein interfaces (2011)

Ahmad, Mazen ; Gu, Wei ; Geyer, Tihamér ; [et al.]

Springer Nature

In: Nature Communications. 2011; 2(1): 261. Published 2011 Mar 29. doi: 10.1038/ncomms1258.

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Publication Date: 2011-03-29

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni (2011)

Geyer, Kathrin K. ; Rodríguez López, Carlos M. ; Chalmers, Iain W. ; [et al.]

Springer Nature

In: Nature Communications. 2011; 2(1): 424. Published 2011 Aug 09. doi: 10.1038/ncomms1433.

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Publication Date: 2011-08-09

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition (2012)

Czudnochowski, Nadine ; Bösken, Christian A. ; Geyer, Matthias

Springer Nature

In: Nature Communications. 2012; 3(1): 842. Published 2012 Jan 01. doi: 10.1038/ncomms1846.

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Publication Date: 2012-01-01

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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