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Description: Article Mutations in the tumour suppressor p53 can produce a protein that has additional functions. Here, the authors describe gain of function mutants of p53 that induce the expression of genes involved in nucleotide metabolism, which increases the activity of GTPases and results in invasion and metastasis. Nature Communications doi: 10.1038/ncomms8389 Authors: Madhusudhan Kollareddy, Elizabeth Dimitrova, Krishna C. Vallabhaneni, Adriano Chan, Thuc Le, Krishna M. Chauhan, Zunamys I. Carrero, Gopalakrishnan Ramakrishnan, Kounosuke Watabe, Ygal Haupt, Sue Haupt, Radhika Pochampally, Gerard R. Boss, Damian G. Romero, Caius G. Radu, Luis A. Martinez

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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LSD1 protects against hippocampal and cortical neurodegeneration (2017)

Michael A. Christopher; Dexter A. Myrick; Benjamin G. Barwick; Amanda K. Engstrom; Kirsten A. Porter-Stransky; Jeremy M. Boss; David Weinshenker; Allan I. Levey; David J. Katz

Springer Nature

In: Nature Communications

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Publication Date: 2017-10-10

Description: LSD1 protects against hippocampal and cortical neurodegeneration Nature Communications, Published online: 9 October 2017; doi:10.1038/s41467-017-00922-9 “LSD1 is a histone demethylase that plays many roles during development. Here, the authors provide evidence that loss of LSD1 in adult mice leads to paralysis and neurodegeneration in the hippocampus and cortex and suggest a potential link between LSD1 and human neurodegenerative disease.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Dispersion/dilution enhances phytoplankton blooms in low-nutrient waters (2017)

Yoav Lehahn; Ilan Koren; Shlomit Sharoni; Francesco d’Ovidio; Assaf Vardi; Emmanuel Boss

Springer Nature

In: Nature Communications

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Publication Date: 2017-04-01

Description: Dispersion/dilution enhances phytoplankton blooms in low-nutrient waters Nature Communications, Published online: 31 March 2017; doi:10.1038/ncomms14868 The degree to which horizontal transport affects phytoplankton ecosystems remains understudied. Here, the authors combine satellite observations, ARGO float data and a simple ecosystem model to explore the impact of horizontal stirring on naturally-stimulated fine-scale phytoplankton blooms.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Seasonal modulation of phytoplankton biomass in the Southern Ocean (2020)

Arteaga, Lionel A. ; Boss, Emmanuel ; Behrenfeld, Michael J. ; [et al.]

Springer Nature

In: Nature Communications. 2020; 11(1): 5364. Published 2020 Oct 23. doi: 10.1038/s41467-020-19157-2.

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Publication Date: 2020-10-23

Description: Over the last ten years, satellite and geographically constrained in situ observations largely focused on the northern hemisphere have suggested that annual phytoplankton biomass cycles cannot be fully understood from environmental properties controlling phytoplankton division rates (e.g., nutrients and light), as they omit the role of ecological and environmental loss processes (e.g., grazing, viruses, sinking). Here, we use multi-year observations from a very large array of robotic drifting floats in the Southern Ocean to determine key factors governing phytoplankton biomass dynamics over the annual cycle. Our analysis reveals seasonal phytoplankton accumulation (‘blooming’) events occurring during periods of declining modeled division rates, an observation that highlights the importance of loss processes in dictating the evolution of the seasonal cycle in biomass. In the open Southern Ocean, the spring bloom magnitude is found to be greatest in areas with high dissolved iron concentrations, consistent with iron being a well-established primary limiting nutrient in this region. Under ice observations show that biomass starts increasing in early winter, well before sea ice begins to retreat. The average theoretical sensitivity of the Southern Ocean to potential changes in seasonal nutrient and light availability suggests that a 10% change in phytoplankton division rate may be associated with a 50% reduction in mean bloom magnitude and annual primary productivity, assuming simple changes in the seasonal magnitude of phytoplankton division rates. Overall, our results highlight the importance of quantifying and accounting for both division and loss processes when modeling future changes in phytoplankton biomass cycles.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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