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Integration of molecular and enzymatic catalysts on graphene for biomimetic generation of antithrombotic species (2014)

Teng Xue; Bo Peng; Min Xue; Xing Zhong; Chin-Yi Chiu; Si Yang; Yongquan Qu; Lingyan Ruan; Shan Jiang; Sergey Dubin; Richard B. Kaner; Jeffrey I. Zink; Mark E. Meyerhoff; Xiangfeng Duan; Yu Huang

Springer Nature

In: Nature Communications

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Publikationsdatum: 2014-02-13

Beschreibung: Article Enzymatic mimics, capable of catalysing cascading reactions under physiological conditions, can be formed from integrating multiple components. Here, the authors report a graphene–haemin–glucose oxidase system capable of biomimetic generation of antithrombotic species from abundant glucose and L -arginine. Nature Communications doi: 10.1038/ncomms4200 Authors: Teng Xue, Bo Peng, Min Xue, Xing Zhong, Chin-Yi Chiu, Si Yang, Yongquan Qu, Lingyan Ruan, Shan Jiang, Sergey Dubin, Richard B. Kaner, Jeffrey I. Zink, Mark E. Meyerhoff, Xiangfeng Duan, Yu Huang

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing (2012)

Keller, Andreas ; Graefen, Angela ; Ball, Markus ; [weitere]

Springer Nature

In: Nature Communications. 2012; 3(1): 698. Published 2012 Jan 01. doi: 10.1038/ncomms1701.

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Publikationsdatum: 2012-01-01

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Integration of molecular and enzymatic catalysts on graphene for biomimetic generation of antithrombotic species (2014)

Xue, Teng ; Peng, Bo ; Xue, Min ; [weitere]

Springer Nature

In: Nature Communications. 2014; 5(1): 3200. Published 2014 Feb 11. doi: 10.1038/ncomms4200.

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Publikationsdatum: 2014-02-11

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome (2021)

Inak, Gizem ; Rybak-Wolf, Agnieszka ; Lisowski, Pawel ; [weitere]

Springer Nature

In: Nature Communications. 2021; 12(1): 1929. Published 2021 Mar 26. doi: 10.1038/s41467-021-22117-z.

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Publikationsdatum: 2021-03-26

Beschreibung: Leigh syndrome (LS) is a severe manifestation of mitochondrial disease in children and is currently incurable. The lack of effective models hampers our understanding of the mechanisms underlying the neuronal pathology of LS. Using patient-derived induced pluripotent stem cells and CRISPR/Cas9 engineering, we developed a human model of LS caused by mutations in the complex IV assembly gene SURF1. Single-cell RNA-sequencing and multi-omics analysis revealed compromised neuronal morphogenesis in mutant neural cultures and brain organoids. The defects emerged at the level of neural progenitor cells (NPCs), which retained a glycolytic proliferative state that failed to instruct neuronal morphogenesis. LS NPCs carrying mutations in the complex I gene NDUFS4 recapitulated morphogenesis defects. SURF1 gene augmentation and PGC1A induction via bezafibrate treatment supported the metabolic programming of LS NPCs, leading to restored neuronal morphogenesis. Our findings provide mechanistic insights and suggest potential interventional strategies for a rare mitochondrial disease.

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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The genetic architecture of human brainstem structures and their involvement in common brain disorders (2020)

Elvsåshagen, Torbjørn ; Bahrami, Shahram ; van der Meer, Dennis ; [weitere]

Springer Nature

In: Nature Communications. 2020; 11(1): 4016. Published 2020 Aug 11. doi: 10.1038/s41467-020-17376-1.

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Publikationsdatum: 2020-08-11

Beschreibung: Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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