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ARID1A protein expression is retained in ovarian endometriosis with ARID1A loss-of-function mutations: implication for the two-hit hypothesis (2020)

Yachida, Nozomi ; Yoshihara, Kosuke ; Suda, Kazuaki ; [et al.]

Springer Nature

In: Scientific Reports. 2020; 10(1): 14260. Published 2020 Aug 31. doi: 10.1038/s41598-020-71273-7.

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Publication Date: 2020-08-31

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

Published by Springer Nature

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Fortnightly atmospheric tides forced by spring and neap tides in coastal waters (2015)

Shinsuke Iwasaki; Atsuhiko Isobe; Yasuyuki Miyao

Springer Nature

In: Scientific Reports

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Publication Date: 2015-05-19

Description: The influence of sea surface temperature (SST) on atmospheric processes over the open ocean has been well documented. However, atmospheric responses to SST in coastal waters are poorly understood. Oceanic stratification (and consequently, SST) in coastal waters largely depends on the fortnightly spring–neap tidal cycle, because of variations in vertical tidal mixing. Here we investigate how changes in SST during the fortnightly tidal cycle affect the lower-level atmosphere over the Seto Inland Sea, Japan. We use a combination of in situ measurements, satellite observations and a regional atmospheric model. We find that the SST in summer shows cool (warm) anomalies over most of the inland sea during spring (neap) tides. Additionally, surface air temperature is positively correlated with the SST as it varies during the fortnightly tidal cycle. Moreover, the fortnightly spring–neap cycle also influences the surface wind speed because the atmospheric boundary layer becomes stabilized or destabilized in response to the difference between air temperature and SST. Scientific Reports 5 doi: 10.1038/srep10167

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

Published by Springer Nature

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Natural occurrence of pure nano-polycrystalline diamond from impact crater (2015)

Hiroaki Ohfuji; Tetsuo Irifune; Konstantin D. Litasov; Tomoharu Yamashita; Futoshi Isobe; Valentin P. Afanasiev; Nikolai P. Pokhilenko

Springer Nature

In: Scientific Reports

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Publication Date: 2015-10-02

Description: Natural occurrence of pure nano-polycrystalline diamond from impact crater Scientific Reports, Published online: 1 October 2015; doi:10.1038/srep14702

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Identification of a novel salt tolerance gene in wild soybean by whole-genome sequencing (2014)

Xinpeng Qi; Man-Wah Li; Min Xie; Xin Liu; Meng Ni; Guihua Shao; Chi Song; Aldrin Kay-Yuen Yim; Ye Tao; Fuk-Ling Wong; Sachiko Isobe; Chi-Fai Wong; Kwong-Sen Wong; Chunyan Xu; Chunqing Li; Ying Wang; Rui Guan; Fengming Sun; Guangyi Fan; Zhixia Xiao; Feng Zhou; Tsui-Hung Phang; Xuan Liu; Suk-Wah Tong; Ting-Fung Chan; Siu-Ming Yiu; Satoshi Tabata; Jian Wang; Xun Xu; Hon-Ming Lam

Springer Nature

In: Nature Communications

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Publication Date: 2014-07-11

Description: Article The identification of genes that control economically important traits is an essential step towards crop improvement. Here the authors sequence the genome of the wild soybean and, through a combined genetic and functional approach, identify a new gene affecting salt tolerance in soybean. Nature Communications doi: 10.1038/ncomms5340 Authors: Xinpeng Qi, Man-Wah Li, Min Xie, Xin Liu, Meng Ni, Guihua Shao, Chi Song, Aldrin Kay-Yuen Yim, Ye Tao, Fuk-Ling Wong, Sachiko Isobe, Chi-Fai Wong, Kwong-Sen Wong, Chunyan Xu, Chunqing Li, Ying Wang, Rui Guan, Fengming Sun, Guangyi Fan, Zhixia Xiao, Feng Zhou, Tsui-Hung Phang, Xuan Liu, Suk-Wah Tong, Ting-Fung Chan, Siu-Ming Yiu, Satoshi Tabata, Jian Wang, Xun Xu, Hon-Ming Lam

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Low temperature hydrogenation of iron nanoparticles on graphene (2014)

Keisuke Takahashi; Yongming Wang; Shotaro Chiba; Yuki Nakagawa; Shigehito Isobe; Somei Ohnuki

Springer Nature

In: Scientific Reports

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Publication Date: 2014-04-09

Description: Hydrogenation of iron nanoparticles was performed both computationally and experimentally where previously chemically-bonded iron hydride is considered to be unachievable under ordinary conditions. Density functional theory (DFT) calculations predict that hydrogenated iron nanoparticles are stabilized on a single-layer graphene/Cu substrate. Experimentally, iron nanoparticles were deposited onto a graphene/Cu substrate by vacuum deposition. Hydrogenation was done at 1atm of hydrogen gas and under liquid nitrogen. Mass spectrometry peak confirmed the hydrogen release from hydrogenated iron nanoparticles while a scanning transmission electron microscopy is used in order to link a geometrical shape of iron hydride nanoparticles between experimental and theoretical treatments. The hydrogenated iron nanoparticles were successfully synthesized where hydrogenated iron nanoparticles are stable under ordinary conditions. Scientific Reports 4 doi: 10.1038/srep04598

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Efficient and cost effective production of active-form human PKB using silkworm larvae (2014)

Ryoko Maesaki; Ryosuke Satoh; Masato Taoka; Teppei Kanaba; Tsunaki Asano; Chiharu Fujita; Toshinobu Fujiwara; Yutaka Ito; Toshiaki Isobe; Toshio Hakoshima; Katsumi Maenaka; Masaki Mishima

Springer Nature

In: Scientific Reports

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Publication Date: 2014-08-16

Description: Protein kinase B (PKB) also known as Akt is involved in many signal transduction pathways. As alterations of the PKB pathway are found in a number of human malignancies, PKB is considered an important drug target for cancer therapy. However, production of sufficient amounts of active PKB for biochemical and structural studies is very costly because of the necessity of using a higher organism expression system to obtain phosphorylated PKB. Here, we report efficient production of active PKBα using the BmNPV bacmid expression system with silkworm larvae. Following direct injection of bacmid DNA, recombinant PKBα protein was highly expressed in the fat bodies of larvae, and could be purified using a GST-tag and then cleaved. A final yield of approximately 1 mg PKBα/20 larvae was recorded. Kinase assays showed that the recombinant PKBα possessed high phosphorylation activity. We further confirmed phosphorylation on the activation loop by mass spectrometric analysis. Our results indicate that the silkworm expression system is of value for preparation of active-form PKBα with phosphorylation on the activation loop. This efficient production of the active protein will facilitate further biochemical and structural studies and stimulate subsequent drug development. Scientific Reports 4 doi: 10.1038/srep06016

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy (2014)

Masamitsu Oshima; Kaoru Inoue; Kei Nakajima; Tetsuhiko Tachikawa; Hiromichi Yamazaki; Tomohide Isobe; Ayaka Sugawara; Miho Ogawa; Chie Tanaka; Masahiro Saito; Shohei Kasugai; Teruko Takano-Yamamoto; Takashi Inoue; Katsunari Tezuka; Takuo Kuboki; Akira Yamaguchi; Takashi Tsuji

Springer Nature

In: Scientific Reports

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Publication Date: 2014-08-14

Description: Bio-hybrid artificial organs are an attractive concept to restore organ function through precise biological cooperation with surrounding tissues in vivo. However, in bio-hybrid artificial organs, an artificial organ with fibrous connective tissues, including muscles, tendons and ligaments, has not been developed. Here, we have enveloped with embryonic dental follicle tissue around a HA-coated dental implant, and transplanted into the lower first molar region of a murine tooth-loss model. We successfully developed a novel fibrous connected tooth implant using a HA-coated dental implant and dental follicle stem cells as a bio-hybrid organ. This bio-hybrid implant restored physiological functions, including bone remodelling, regeneration of severe bone-defect and responsiveness to noxious stimuli, through regeneration with periodontal tissues, such as periodontal ligament and cementum. Thus, this study represents the potential for a next-generation bio-hybrid implant for tooth loss as a future bio-hybrid artificial organ replacement therapy. Scientific Reports 4 doi: 10.1038/srep06044

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Concyclic CH-π arrays for single-axis rotations of a bowl in a tube (2018)

Taisuke Matsuno; Masahiro Fujita; Kengo Fukunaga; Sota Sato; Hiroyuki Isobe

Springer Nature

In: Nature Communications

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Publication Date: 2018-09-18

Description: Concyclic CH-π arrays for single-axis rotations of a bowl in a tube Concyclic CH-π arrays for single-axis rotations of a bowl in a tube, Published online: 17 September 2018; doi:10.1038/s41467-018-06270-6 The weak and directional CH-π hydrogen bond has rarely been exploited in the design of supramolecular complexes and molecular machinery. Here, the authors construct a bowl-in-tube complex stabilized solely by concyclic CH-π hydrogen bonds, and show that the guest exhibits single-axis rotational motion despite tight association with the host.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination (2013)

Yuichiro Saito; Jun Takeda; Masahiro Okada; Junya Kobayashi; Akihiro Kato; Kouji Hirota; Masato Taoka; Tomohiro Matsumoto; Kenshi Komatsu; Toshiaki Isobe

Springer Nature

In: Scientific Reports

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Publication Date: 2013-06-20

Description: Although RAD52 plays a critical role in the initiation of homologous recombination (HR) by facilitating the replacement of RPA with RAD51, the mechanism controlling RAD52 remains elusive. Here, we show that Bag101, a factor implicated in proteasome functioning, regulates RAD52 protein levels and subsequent HR. LC-MS/MS analysis identified Bag101 which binds to Rad22, the fission yeast homologue of RAD52. Bag101 reduced HR frequency through its overexpression and conversely, HR frequencies were enhanced when it was deleted. Consistent with this observation, Rad22 protein levels was reduced in cells where bag101 was overexpressed even when Rad22 transcription was up-regulated, suggesting the operation of proteasome-mediated Rad22 degradation. Indeed, Rad22 protein levels were stabilized in proteasome mutants. Rad22 physically interacted with the BAG domain of Bag101, and a lack of this domain enhanced HR frequency. Similarly, radiation exposure triggered the dissociation of these proteins so that Rad22 was stabilized and able to enhance HR. Scientific Reports 3 doi: 10.1038/srep02022

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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Evaluation of the heterogeneous tissue distribution of erlotinib in lung cancer using matrix-assisted laser desorption ionization mass spectrometry imaging (2017)

Yukari Tsubata; Mitsuhiro Hayashi; Ryosuke Tanino; Hiroaki Aikawa; Mayu Ohuchi; Kenji Tamura; Yasuhiro Fujiwara; Takeshi Isobe; Akinobu Hamada

Springer Nature

In: Scientific Reports

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Publication Date: 2017-10-04

Description: Evaluation of the heterogeneous tissue distribution of erlotinib in lung cancer using matrix-assisted laser desorption ionization mass spectrometry imaging Scientific Reports, Published online: 3 October 2017; doi:10.1038/s41598-017-13025-8

Electronic ISSN: 2045-2322

Topics: Natural Sciences in General

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