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Articles (8)
PNAS - Proceedings of the National Academy of Sciences (3)
PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(8): 2736-2741. Published 2005 Jan 24. doi: 10.1073/pnas.0403510102. (1)
PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(33): 13349-13354. Published 2007 Aug 07. doi: 10.1073/pnas.0705889104. (1)
PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(45): E3084-E3093. Published 2012 Oct 10. doi: 10.1073/pnas.1212457109. (1)
PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(48): E3324-E3333. Published 2012 Nov 12. doi: 10.1073/pnas.1211902109. (1)
PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(41): 14800-14805. Published 2014 Oct 01. doi: 10.1073/pnas.1409588111. (1)
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Synergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response (2012)

Venturelli, O. S. ; El-Samad, H. ; Murray, R. M.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(48): E3324-E3333. Published 2012 Nov 12. doi: 10.1073/pnas.1211902109.

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Publication Date: 2012-11-12

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Delayed Ras/PKA signaling augments the unfolded protein response (2014)

Pincus, D. ; Aranda-Diaz, A. ; Zuleta, I. A. ; [et al.]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(41): 14800-14805. Published 2014 Oct 01. doi: 10.1073/pnas.1409588111.

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Publication Date: 2014-10-01

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses (2012)

Fordyce, P. M. ; Pincus, D. ; Kimmig, P. ; [et al.]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(45): E3084-E3093. Published 2012 Oct 10. doi: 10.1073/pnas.1212457109.

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Publication Date: 2012-10-10

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Surviving heat shock: Control strategies for robustness and performance (2005)

El-Samad, H. ; Kurata, H. ; Doyle, J. C. ; [et al.]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(8): 2736-2741. Published 2005 Jan 24. doi: 10.1073/pnas.0403510102.

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Publication Date: 2005-01-24

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Dual-mode binding by a bZIP transcription factor [Biophysics and Computational Biology] (2012)

Fordyce, P. M., Pincus, D., Kimmig, P., Nelson, C. S., El-Samad, H., Walter, P., De; Risi, J. L.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2012-11-08

Description: A quantitative understanding of how transcription factors interact with genomic target sites is crucial for reconstructing transcriptional networks in vivo. Here, we use Hac1, a well-characterized basic leucine zipper (bZIP) transcription factor involved in the unfolded protein response (UPR) as a model to investigate interactions between bZIP transcription factors and...

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

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Asymmetric partition of yeast proteome and aging [Systems Biology] (2015)

Yang, J., McCormick, M. A., Zheng, J., Xie, Z., Tsuchiya, M., Tsuchiyama, S., El-Samad, H., Ouyang, Q., Kaeberlein, M., Kennedy, B. K., Li, H.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2015-09-23

Description: Budding yeast divides asymmetrically, giving rise to a mother cell that progressively ages and a daughter cell with full lifespan. It is generally assumed that mother cells retain damaged, lifespan limiting materials (“aging factors”) through asymmetric division. However, the identity of these aging factors and the mechanisms through which they...

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

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Dual feedback loops generate bimodal response [Systems Biology] (2012)

Venturelli, O. S., El-Samad, H., Murray, R. M.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2012-11-28

Description: Feedback loops are ubiquitous features of biological networks and can produce significant phenotypic heterogeneity, including a bimodal distribution of gene expression across an isogenic cell population. In this work, a combination of experiments and computational modeling was used to explore the roles of multiple feedback loops in the bimodal, switch-like...

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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