Publication Date:
2012-02-15
Description:
Recently, Rogers and Crocker (1) proposed a method to predict the interaction between colloids coated with two kinds of ssDNA, A and B. A key step in ref. 1 was to estimate the average number of DNA bonds, 〈N〉, assuming local chemical equilibrium (LCE) between hybridized and unhybridized sticky end concentrations:CX(r) and are the concentrations of X with or without hybridization, ΔG0 is the solution hybridization free energy of A and B (2), and ρ0 is 1 M.Here, we show that LCE predictions differ from simulation results obtained using standard statistical mechanics (SM). We consider the same model as ref....
Keywords:
Letters
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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