Publication Date:
2016-02-13
Description:
A new phytochemical study of the indigenous Brazilian species Hippeastrum papilio is reported herein. Three novel Amaryllidaceae alkaloids were isolated, including hippapiline ( 1 ), papiline ( 2 ), and 3- O -demethyl-3- O -(3-hydroxybutanoyl)haemanthamine ( 3 ). Their structures were determined by physical and spectroscopic methods. In addition, the known alkaloids, haemanthamine ( 4 ), galanthamine ( 5 ), narwedine ( 6 ), 11 β -hydroxygalanthamine ( 7 ), apogalanthamine ( 8 ), and 9- O -demethyllycosinine B ( 9 ) were identified. The unusual cis-B / C -ring fusion for the new homolycorine representative hippapiline was ratified by NMR and CD spectroscopy.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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