ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

Hits per page

hit 1 - 1 | 1 hit

Sorting

Unknown

Crystal structure of 9-(4-bromobutyl)-9H-fluorene-9-carboxylic acid (2014)

Zhang, X.-Y.Liu, B.-N.Wang, P.-B.Liu, D.-K.

International Union of Crystallography (IUC)

In: Acta Crystallographica Section E

add to mindlist on the mindlist

Details

Publication Date: 2014-09-28

Description: The title compound, C18H17BrO2, is a key intermediate in the synthesis of lomitapide mesylate, a microsomal triglyceride transfer protein inhibitor. Its asymmetric unit contains two independent molecules with slightly different conformations; the mean planes of the 4-bromobutyl and carboxylate groups in the two molecules form dihedral angles of 24.54 (12) and 17.10 (18)°. In the crystal, carboxylate groups are involved in O—H...O hydrogen bonding, which leads to the formation of two crystallographically independent centrosymmetric dimers. Weak intermolecular C—H...O interactions further link these dimers into layers parallel to the bc plane.

Keywords: crystal structurelomitapide mesylatehydrogen bonding

Electronic ISSN: 1600-5368

Topics: Chemistry and Pharmacology , Geosciences

Published by International Union of Crystallography (IUC)

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

PAPER CURRENT

S·F·X

Fulltext

hit 1 - 1 | 1 hit