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  • 1
    Publication Date: 2024-04-05
    Description: The early postnatal period is a crucial stage for hippocampal development. During this critical period, the neonatal hippocampus is highly sensitive to the detrimental consequences of adverse environmental factors. Extensive clinical and preclinical evidence has shown that traumatic events early in life have profound and persistent effects on hippocampal function and behavior. This research topic focuses on the acute and lasting effects of early-life stress on various developmental processes in the hippocampus, and aims to uncover the molecules that are responsible for early-life stress-programmed effects and underlie resilience or vulnerability to stress-related neuropsychiatric disorders later in life. We hope the articles in this research topic will provide novel insights and stimulate future studies on the mechanisms of early-life stress and brain development.
    Keywords: RC321-571 ; Q1-390 ; development ; molecular mechanism ; early-life stress ; plasticity ; Hippocampus ; psychiatric disorders ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 2
    Publication Date: 2024-03-29
    Description: Coordinating one’s behavior with the behavior of other individuals is a fundamental feature of everyday social interaction. A defining feature of such behavior is that it is dynamic, that is, it evolves over time. This is true whether one considers the linguistic, gestural and non-verbal coordination that occurs between two or more individuals engaged in a conversation or the physical movement coordination that occurs when two or more people clear a dinner table or load a dishwasher together. Such behavior is also emergent and robust to sudden changes in task context or unexpected environmental or social perturbations. Accordingly, robust social action and multi-agent coordination is synergistic, with co-acting individuals adapting to each other and the environment around them in a mutual and reciprocal manner. Research investigating the behavioral dynamics of joint-action and multi-agent coordination has steadily increased over the last several decades. Spurred by several factors, including (i) the increased accessibility of technologies for recording and extracting the time-evolution of multi-agent behavior (e.g., motion tracking, eye-tracking, EEG), (ii) the development of new nonlinear techniques for analyzing behavioral and linguistic time-series data, and (iii) a growing appreciation that social cognition, perception, and action are interdependent, embodied and embedded processes, this research has not only been directed towards measuring and identifying the stable patterns of coordinated social and multi-agent activity that emerge over time, but also how these stable pattern are activated, dissolved, transformed, and exchanged over time. Not surprisingly, researchers have begun to investigate the implications of this behavioral dynamics perspective for understanding social cognitive processes as well as clinical disorders with social deficits such as autism and schizophrenia. Attempts at modeling the dynamics of social action and multi-agent behavior using various nonlinear and complex systems methods has also increased over the last several years, with many researchers demonstrating how simple low-dimensional dynamical or computational models can be employed to capture and explain the dynamics of ongoing joint-action and multi-agent behavior. A characteristic feature of these dynamical models is that they reveal how stable social action and multi-agent coordination arises naturally from the interaction of the physical, biomechanical, neural, informational, and social cognitive properties of a joint-action task context and goal, and cannot be ascribed to any one singular processes, agent, or level of analysis. The implications of these modeling endeavors for the design of robust and adaptive human-machine systems and robotic agents has not gone unnoticed, with a growing body of work now devoted to such joint-action, (bio)-inspired human-robotic interaction initiatives.
    Keywords: BF1-990 ; Q1-390 ; multi-agent activity ; social coordination ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Language: English
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  • 3
    Publication Date: 2024-04-05
    Description: The cytoplasmic free Ca2+ concentration ([Ca2+]i) is a key determinant of neuronal information transfer and processing. It controls a plethora of fundamental processes, including transmitter release and the induction of synaptic plasticity. This enigmatic second messenger conveys its wide variety of actions by binding to a subgroup of Ca2+ binding proteins (CaBPs) known as “Ca2+ sensors”. Well known examples of Ca2+ sensors are Troponin-C in skeletal muscle, Synaptotagmin in presynaptic terminals, and Calmodulin (CaM) in all eukaryotic cells. Since the levels of [Ca2+]i directly influence the potency of Ca2+ sensors, the Ca2+ concentration is tightly controlled by several mechanisms including another type of Ca2+ binding proteins, the Ca2+ buffers. Prominent examples of Ca2+ buffers include Parvalbumin (PV), Calbindin-D28k (CB) and Calretinin (CR), although for the latter two Ca2+ sensor functions were recently also suggested. Ca2+ buffers are distinct from sensors by their purely buffering action, i.e. they influence the spatio-temporal extent of Ca2+ signals, without directly binding downstream target proteins. Details of their action depend on their binding kinetics, mobility, and concentration. Thus, neurons can control the range of action of Ca2+ by the type and concentration of CaBPs expressed. Since buffering strongly limits the range of action of free Ca2+, the structure of the Ca2+ signaling domain and the topographical relationships between the sites of Ca2+ influx and the location of the Ca2+ sensors are central determinants in neuronal information processing. For example, postsynaptic dendritic spines act to compartmentalize Ca2+ depending on their geometry and expression of CaBPs, thereby influencing dendritic integration. At presynaptic sites it has been shown that tight, so called nanodomain coupling between Ca2+ channels and the sensor for vesicular transmitter release increases speed and reliability of synaptic transmission. Vice versa, the influence of an individual CaBP on information processing depends on the topographical relationships within the signaling domain. If e.g. source and sensor are very close, only buffers with rapid binding kinetics can interfere with signaling. This Research Topic contains a collection of work dealing with the relationships between different [Ca2+]i controlling mechanisms in the structural context of synaptic sites and their functional implications for synaptic information processing as detailed in the Editorial.
    Keywords: RC321-571 ; Q1-390 ; localization ; dendritic integration ; calcium buffer ; storm ; Calcium ; transmitter release ; calcium sensor ; STED ; plasticity ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 4
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Competitiveness describes a key ability important for plants to grow and survive abiotic and biotic stresses. Under optimal, but particularly under non-optimal conditions, plants compete for resources including nutrients, light, water, space, pollinators and other. Competition occurs above- and belowground. In resource-poor habitats, competition is generally considered to be more pronounced than in resource-rich habitats. Although competition occurs between different players within an ecosystem such as between plants and soil microorganisms, our topic focusses on plant-plant interactions and includes inter-specific competition between different species of similar and different life forms and intra-specific competition. Strategies for securing resources via spatial or temporal separation and different resource needs generally reduce competition. Increasingly important is the effect of invasive plants and subsequent decline in biodiversity and ecosystem function. Current knowledge and future climate predictions suggest that in some situations competition will be intensified with occurrence of increased abiotic (e.g. water and nutrient limitations) and biotic stresses (e.g. mass outbreak of insects), but competition might also decrease in situations where plant productivity and survival declines (e.g. habitats with degraded soils). Changing interactions, climate change and biological invasions place new challenges on ecosystems. Understanding processes and mechanisms that underlie the interactions between plants and environmental factors will aid predictions and intervention. There is much need to develop strategies to secure ecosystem services via primary productivity and to prevent the continued loss of biodiversity. This Research Topic provides an up-to-date account of knowledge on plant-plant interactions with a focus on identifying the mechanisms underpinning competitive ability. The Research Topic aims to showcase knowledge that links ecological relevance with physiological processes to better understanding plant and ecosystem function.
    Keywords: QK1-989 ; Q1-390 ; conservation ; Global Warming ; Climate Change ; invasion ; plant-plant interactions ; competition ; facilitation ; Allelochemicals ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Language: English
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  • 5
    Publication Date: 2024-03-29
    Description: Conflict adaptation theory is one of the most popular theories in cognitive psychology. The theory argues that participants strategically modulate attention away from distracting stimulus features in response to conflict. Although results with proportion congruent, sequential congruency, and similar paradigms seem consistent with the conflict adaptation view, some researchers have expressed scepticism. The paradigms used in the study of conflict adaptation require the manipulation of stimulus frequencies, sequential dependencies, time-on-task regularities, and various other task regularities that introduce the potential for learning of conflict-unrelated information. This results in the unintentional confounding of measures of conflict adaptation with simpler learning and memory biases. There are also alternative accounts which propose that attentional adaptation does occur, but via different mechanisms, such as valence, expectancy, or effort. A significant (and often heated) debate remains surrounding the question of whether conflict adaptation exists independent of these alternative mechanisms of action. The aim of this Research Topic is to provide a forum for current directions in this area, considering perspectives from all sides of the debate.
    Keywords: BF1-990 ; Q1-390 ; cognitive control ; Gratton effect ; Proportion Congruent ; conflict adaptation ; timing ; Attention ; contingency learning ; congruency sequence effect ; binding ; expectancies ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Language: English
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  • 6
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    Frontiers Media SA
    Publication Date: 2024-04-11
    Description: The understanding of biological complexity has been greatly facilitated by cross-disciplinary, holistic approaches that allow insights into the function and regulation of biological processes that cannot be captured by dissecting them into their individual components. In addition, the development of novel tools has dramatically increased our ability to interrogate information at the nucleic acid, protein and metabolite level. The integration and interpretation of disparate data sets, however, still remain a major challenge in systems biology. Roots provide an excellent model for studying physiological, developmental, and metabolic processes. The availability of genetic resources, along with sequenced genomes has allowed important discoveries in root biochemistry, development and function. Roots are transparent, allowing optical investigation of gene activity in individual cells and experimental manipulation. In addition, the predictable fate of cells emerging from the root meristem and the continuous development of roots throughout the life of the plant, which permits simultaneous observation of different developmental stages, provide ideal premises for the analysis of growth and differentiation. Moreover, a genetically fixed cellular organization allows for studying the utilization of positional information and other non-cell-autonomous phenomena, which are of utmost importance in plant development. Although their ontogeny is largely invariant under standardized experimental conditions, roots possess an extraordinary capacity to respond to a plethora of environmental signals, resulting in distinct phenotypic readouts. This high phenotypic plasticity allows research into acclimative and adaptive strategies, the understanding of which is crucial for germplasm enhancement and crop improvement. With the aim of providing a current snapshot on the function and development of roots at the systems level, this Research Topic collated original research articles, methods articles, reviews, mini reviews and perspective, opinion and hypotheses articles that communicate breakthroughs in root biology, as well as recent advances in research technologies and data analysis.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; root architecture ; Synthetic Biology ; auxin ; gene co-expression analysis ; nutrient acquisition ; root hairs ; Systems Biology ; regulatory peptides ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 7
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    Frontiers Media SA
    Publication Date: 2022-01-31
    Description: Multi-item surveys are frequently used to study scores on latent factors, like human values, attitudes and behavior. Such studies often include a comparison, between specific groups of individuals, either at one or multiple points in time. If such latent factor means are to be meaningfully compared, the measurement structures including the latent factor and their survey items should be stable across groups and/or over time, that is ‘invariant’. Recent developments in statistics have provided new analytical tools for assessing measurement invariance (MI). The aim of this special issue is to provide a forum for a discussion of MI, covering some crucial ‘themes’: (1) ways to assess and deal with measurement non-invariance; (2) Bayesian and IRT methods employing the concept of approximate measurement invariance; and (3) new or adjusted approaches for testing MI to fit increasingly complex statistical models and specific characteristics of survey data. The special issue started with a kick-off meeting where all potential contributors shared ideas on potential papers. This expert workshop was organized at Utrecht University in The Netherlands and was funded by the Netherlands Organization for Scientific Research (NWO-VENI-451-11-008). After the kick-off meeting the authors submitted their papers, all of which were reviewed by experts in the field. The papers in the eBook are listed in alphabetical order, but in the editorial the papers are introduced thematically. Although it is impossible to cover all areas of relevant research in the field of MI, papers in this eBook provide insight on important aspects of measurement invariance. We hope that the discussions included in this special issue will stimulate further research on MI and facilitate further discussions to support the understanding of the role of MI in multi-item surveys.
    Keywords: BF1-990 ; Q1-390 ; Non-invariance ; Partial Invariance ; Structural Equation Modeling ; bayesian statistics ; cross national surveys ; Measurement invariance ; Approximate invariance ; multiple group analysis
    Language: English
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