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  • 1
    Online Resource
    Online Resource
    Advanced Imaging and Bio Techniques for Convergence Science (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Biomedical engineering. ; Biotechnology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: 1.Confocal laser scanning microscopy and fluorescence correlation methods for evaluation of molecular interactions -- 2.Number and Brightness Imaging: visualization of protein oligomerization state in living cell -- 3.Single-molecule analysis on the coupling of molecular state and reaction kinetics -- 4.Imaging lipid rafts in the plasma membrane using novel probe and super-resolution microscopy -- 5.Multiplex Immunohistochemistry (IHC) -- 6.Micro-endoscopy for live small animal fluorescent imaging -- 7.Immuno-gold techniques -- 8.Correlative Light and Electron Microscopy for Nanoparticle-Cell Interaction -- 9.Diagnostic and Therapeutic Nanomedicine -- 10.Semiconductor nanocrystals for biological imaging and fluorescence spectroscopy -- 11.DNA/RNA fluorescence imaging by synthetic nucleic acids -- Section II: Label-free techniques and advanced tomographic imaging -- 12.“Magnetic resonance imaging for preclinical study -- 13.Holotomography techniques for 3D label-free imaging of live cells and tissues -- 14.Dynamic-contrast optical imaging techniques -- 15.Emerging biological and clinical applications of photoacoustic tomography -- Section III: Potential (synergic) biotechnologies to be joined with imaging techniques -- 16.Generation of genetically-engineered mouse models using CRISPR-Cas system -- 17.Highly efficient generation of cell lines stably expressing genes of interest via Cre recombinase mediated knock-in method in mouse embryonic stem (ES) cells and its application for microscopic imaging techniques -- 18.Mass spectrometry based metabolomics in translational research -- 19.Application of mass spectrometry in drug metabolism and pharmacokinetics for drug development -- 20.Discovery and Application of Chemical Probes for Translational Research -- 21.Regeneration of skin cells by mesenchymal stem cell-derived exosomes.
    Abstract: This book is a wide-ranging guide to advanced imaging techniques and related methods with important applications in translational research or convergence science as progress is made toward a new era in integrative healthcare. Conventional and advanced microscopic imaging techniques, including both non-fluorescent (i.e., label-free) and fluorescent methods, have to date provided researchers with specific and quantitative information about molecules, cells, and tissues. Now, however, the different imaging techniques can be correlated with each other and multimodal methods developed to simultaneously obtain diverse and complementary information. In addition, the latest advanced imaging techniques can be integrated with non-imaging techniques such as mass spectroscopic methods, genome editing, organic/inorganic probe synthesis, nanomedicine, and drug discovery. The book will be of high value for researchers in the biological and biomedical sciences or convergence science who need to use these multidisciplinary and integrated techniques or are involved in developing new analytical methods focused on convergence science. .
    Type of Medium: Online Resource
    Pages: VI, 564 p. 191 illus., 161 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813360648
    Series Statement: Advances in Experimental Medicine and Biology, 1310
    URL: https://doi.org/10.1007/978-981-33-6064-8
    DOI: 10.1007/978-981-33-6064-8
    DDC: 660.6
    Language: English
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  • 2
    Online Resource
    Online Resource
    GM3 Signaling (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Molecular genetics. ; Cancer. ; Genetics. ; Biochemistry. ; Biological transport. ; Cell membranes. ; Molecular Genetics. ; Cancer Biology. ; Genetics and Genomics. ; Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. History of sialic acids, gangliosides and GM3 -- 2. Synthesis of GM3 -- 3. Molecular localization of GM3 in cells -- 4. Basic function of GM3 as an interacting molecule -- 5. GD3 mimetics with a neurite forming capacity -- 6. GM3 as a pathogenic infection receptor -- 7. GM3 and related gangliosides prevent inflammation and atherosclerosis -- 8. GM3 has an anti-tumor capacity -- 9. GM3 suppresses tumor angiogenesis -- 10. Interaction between EGFR and GM3 -- 11. Membrane ganglioside-specific neuraminidase 3 (NEU3) regulates GM3 signaling -- 12. Regulation of GM3-mediated EGFR signaling by NEU3 sialidase -- 13. VEGFR-GM3 interaction in angiogenesis -- 14. GM3, competing with GM1, interaction with urokinase plasminogen activator receptor (uPAR) in endothelial caveolar-lipid rafts inhibits angiogenesis -- 15. GM3 interacts with TGFβ Rs in the epithelial-mesenchymal transition (EMT) during posterior capsular opacification (PCO) formation -- 16. Galectin-1 promotes tumor growth and escapes immune surveillance -- 17. GM3-HGFR, FGFR and PDGFR cancer cell behavior, and IGF-1R in diabetic wound healing -- 18. GM3, caveolin-1 and insulin receptor in insulin resistance -- 19. GM3 suppresses arthritis -- 20. GM3 protects cochlear hair cells and hearing from corti degeneration -- 21. GM3 increases osteoclast differentiation via direct GM3 cooperation with RANKL and IGF-1 -- 22. GM3 in leukemic cells into terminal differentiation -- 23. α2,3-Sialyllactose (3SL) or α2,6-sialyllactose (6SL) of GM3 glycan in innate immunity. .
    Abstract: This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.
    Type of Medium: Online Resource
    Pages: VII, 138 p. 32 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811556524
    URL: https://doi.org/10.1007/978-981-15-5652-4
    DOI: 10.1007/978-981-15-5652-4
    DDC: 572.8
    Language: English
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  • 3
    Online Resource
    Online Resource
    Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Neurosciences. ; Immunology. ; Physiology. ; Neuropsychology. ; Psychiatry. ; Neuroscience. ; Immunology. ; Physiology. ; Neuropsychology. ; Psychiatry.
    Description / Table of Contents: 1.How Immune-inflammatory processes link neurodegenerative and psychiatric disorders -- 2.Gut-Microbiota-Brain Axis: pathophysiological mechanism in neuropsychiatric disorders -- 3.Microbiome- induced autoimmunity and novel therapeutic intervention -- 4.The key role of microlia and circulating monocytes in etipathology neuropsychiatric disorders -- 5.Neuro-immuno-epigenetics of prenatal psychological stress -- 6.C-reactive protein (CRP): a potent inflammation biomarker in psychiatric disorders -- 7.Neuroinflammation, neurognesis and neuroprotection in schizophrenia -- 8.Autoimmue psycosis: concept, clinical manifestation and management -- 9.Stress, autonomic nervous system and kynurenine pathway in major depression -- 10.Brain-gut-microbiome axis in major depression : novel therapeutic approach -- 11.Glial-Neuronal Interaction in Synapses: A Possible Mechanism of the Pathophysiology of Bipolar Disorder -- 12.Neuroimmaging of inflammation in depression and anxiety disorders -- 13.Neuroinflammation and immune-kynureinine pathway in anxiety disorders -- 14.Inflammatory-mediated responses in development of neurogeneartive diseases -- 15.The connection between gut-brain axis and PTSD -- 16.Eating disorders : Gut microbiota-immune-brain interactions -- 17.Sleep-immune crosstalk and sleep disorders -- 18.Obsessive-compulsive disorder: immuno-inflammatory disorder? -- 19.Cytokine, neuroinflammation and neurodeneration in Alzheimer’s disease -- 20.Molecular imaging of neuroinflammation in Alzheimer's disease and MCI -- 21.The role of N-Methyl-D-Aspartate Receptor Neurotransmission and mictobiota in Alzheimer’s disease -- 22.Neuroglial activation and neuroinflammation in the brain of patients with autism -- 23.Suicide and inflammation -- 24.Anti-inflammatory effect of Traditional Chinese Medicine on the concept of Mind-body interface -- 25.Anti-inflammatory therapy as a promising target in neupsychiatric disorders.
    Abstract: This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.
    Type of Medium: Online Resource
    Pages: XVII, 554 p. 28 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811973765
    Series Statement: Advances in Experimental Medicine and Biology, 1411
    URL: https://doi.org/10.1007/978-981-19-7376-5
    DOI: 10.1007/978-981-19-7376-5
    DDC: 612.8
    Language: English
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  • 4
    Online Resource
    Online Resource
    Recent Advances in Edible Fats and Oils Technology : Processing, Health Implications, Economic and Environmental Impact (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Lipids. ; Food science. ; Biotechnology. ; Lipidology. ; Food Science.
    Description / Table of Contents: Chapter 1. Vegetable Oils and Animal Fats: Sources, Properties and Recovery -- Chapter 2. Exotic Oil: Sources, Properties and Recovery -- Chapter 3. Seed Oil: Sources, Properties and Recovery -- Chapter 4. Vegetable Oil Refining -- Chapter 5. MINOR COMPONENTS IN EDIBLE OIL -- Chapter 6. Blending, Hydrogenation, Fractionation and Interesterification Processing -- Chapter 7. Ionic Liquid as a Green Solvent for Lipid Processing -- Chapter 8. Diacylglycerol Oil: Health Benefits, Synthesis and Applications -- Chapter 9. Medium-and Long-Chain Triacylglycerol: Production, Health Effects and Applications -- Chapter 10. Enzymatic synthesis of human milk fat substitutes -- Chapter 11. Cocoa Butter Alternatives for Food Applications -- Chapter 12. Oleogel: Production and Application -- Chapter 13. Characterization of Nanoemulsions: The Way Forward -- Chapter 14. Processing Contaminants In Edible Oil -- Chapter 15. Enzymatic Biodiesel Production from Low-Quality Waste Oils and Non-edible Oils: Current Status and Future Prospects -- Chapter 16. Sustainability and Traceability in the Malaysian Oil Palm Industry -- Chapter 17. Adulteration in Oils and Fats Industry.
    Abstract: This book is written by international experts with both academic and industrial credentials. It presents for the first time, a collection of up-­to-­date scientific advances in the area of edible fats and oils technology, over a span of 10 years from 2009 to the year 2019. The book covers the existing and recent advanced techniques adopted in the edible fats and oils research and touches on the processing and modification, to the traceability and sustainability issues of fats and oils. Some recent technologies like supercritical carbon dioxide, microwave, ultrasound, and enzymatic‐ assisted processes, ionic liquid, enzymatic processes, biosensor and membrane technology are presented in the book. The book aims to provide the technologists and researchers in research, development and operations in the edible fats and oils industries with critical and readily accessible information on the recent advances in the field. The book is divided into three broad sections- Fats and Oils Chemistry and Processing, Fats and Oils Modification and Health Implications, and Fats and Oils Safety, Social, Environmental and Economic Impacts. It is an extremely comprehensive and valuable resource, which serves as an essential reference for students and lipid scientists from academia or industry.
    Type of Medium: Online Resource
    Pages: X, 492 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811651137
    URL: https://doi.org/10.1007/978-981-16-5113-7
    DOI: 10.1007/978-981-16-5113-7
    DDC: 660.6
    Language: English
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  • 5
    Online Resource
    Online Resource
    Ganglioside Biochemistry (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Molecular genetics. ; Cancer. ; Genetics. ; Biochemistry. ; Biological transport. ; Cell membranes. ; Molecular Genetics. ; Cancer Biology. ; Genetics and Genomics. ; Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: Preface: Carbohydrates- the third life chain -- 1. Glycosylation -- 2. N-Glycan and O-glycan glycosylation in eukaryotes -- 3. Sialyltransferase, sialylation and sulfoylation -- 4. Congenital disorders of glycosylation (CDG) of N-glycoprotein -- 5. Neuraminic acids/sialic acids (N-acetyl- and N-glycolylneuraminic acid) -- 6. Biosynthesis of sialic acid -- 7. Neu5Gc (N-glycolylneuraminic acid) -- 8. Gangliosides -- 9. Gangliosides and tumor-associated ganglioside (TAG) modulate receptor-tyrosine kinases (RTKs) -- 10. Sialic acids and TAGs of tumor cells to escape immunesurveillance and immuneediting -- 11. Tumor characteristics in tumor related carbohydrates.
    Abstract: This book presents the latest knowledge and the most recent research results in the field of ganglioside biochemistry. The early chapters cover all relevant background on sialic acids and their biosynthesis, on N-glycolylneuraminic acid (Neu5Gc), which cannot be synthesized by humans, and on general aspects of ganglioside research. Ganglioside adsorption, disorders of ganglioside degradation, and the regulation of gangliosides are thoroughly discussed. A major focus of the book is the role of gangliosides in cancer. Here, the discussion encompasses, for example, the biological importance, antigenicity, and immunological actions of tumor-associated gangliosides (TAGs), the significance of different glycolipids and gangliosides as TAGs, and emerging anti-cancer vaccine strategies. The ability of sialic acids and TAGs of tumor cells to escape immunosurveillance and immunoediting also receives detailed attention. The significance of sialic acids in regulation of the complement system is explained, and the closing chapter focuses especially on the role of sialyl T antigen in cancer. The book will be of value for all who are interested in functional glycobiology and glycomic studies.
    Type of Medium: Online Resource
    Pages: XVI, 214 p. 57 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811558153
    URL: https://doi.org/10.1007/978-981-15-5815-3
    DOI: 10.1007/978-981-15-5815-3
    DDC: 572.8
    Language: English
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  • 6
    Online Resource
    Online Resource
    Estuaries and Coastal Zones in Times of Global Change : Proceedings of ICEC-2018 (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Physical geography. ; Climatology. ; Water. ; Hydrology. ; Engineering geology. ; Oceanography. ; Earth System Sciences. ; Climate Sciences. ; Water. ; Geoengineering. ; Ocean Sciences.
    Description / Table of Contents: 1. A 14-year Multi-sites and High-frequency Monitoring of Salinity in the Tidal Garonne River (S-W France) Reveals Marked Inter-annual Variability In Marine Intrusion -- 2. Study on Salinity Intrusion and Mixing Types in a Conceptual Estuary using 3-D Hydrodynamic Simulation: Effects of Length, Width, Depth, and Bathymetry -- 3. Response of Salinity Intrusion to the Fictitious Blockade of the North Branch in the Yangtze Estuary, China -- 4. Influence of the Salinity Intrusion on Island Water Source Safety: A Case Study of the Chongming Island, China -- 5. Law of salt tide intrusion of the Qiantang Estuary and its numerical simulation -- 6. Seasonal salinity variations in a coastal wetland induced by complex interactions between sea, river and evapoconcentration processes -- 7. Water Quality Mitigation Scenarios for Burullus Coastal Lake, Egypt -- 8. Research on the Setting Condition of Tailrace Surge Chambers for Seawater Pumped-storage Power Stations with Long Tailrace Tunnels.
    Abstract: This book is a collection of extended papers based on presentations given during the ICEC 2018 conference, held in Caen, France, in August 2018. It explores both the limitations and advantages of current models, and highlights the latest developments concerning new numerical schemes, high-performance computing, multi-physics and multi-scale methods, and better interaction with field or scale model data. Accordingly, it addresses the interests of practitioners, stakeholders, researchers, and engineers active in this field. .
    Type of Medium: Online Resource
    Pages: XX, 843 p. 494 illus., 402 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811520815
    Series Statement: Springer Water,
    URL: https://doi.org/10.1007/978-981-15-2081-5
    DOI: 10.1007/978-981-15-2081-5
    DDC: 550
    Language: English
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  • 7
    Online Resource
    Online Resource
    Anxiety Disorders : Rethinking and Understanding Recent Discoveries (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Neurosciences. ; Neuropsychology. ; Neuroscience. ; Neuropsychology.
    Description / Table of Contents: Part 1. Brain network concepts -- Chapter 1. Task MRI-based functional brain network of anxiety -- Chapter 2. Phenotype network and brain structural covariance network of anxiety -- Chapter 3. linear/nonlinear micro-and-macro state EEG-based functional networks for anxiety -- Chapter 4. White matter-based structural brain network of anxiety -- Chapter 5. Resting state abnormalities in anxiety disorders and spatiotemporal psychopathology -- Part 2. Neurobiological Aspects -- Chapter 6. Gene-environmental interactions and role of epigenetics in anxiety disorders -- Chapter 7. The role of the oxytocin system in anxiety disorders -- Chapter 8. Translational studies in the complex roles of neurotransmitter systems in anxiety and anxiety disorders -- Chapter 9. The role of early life stress in HPA axis dysfunction in anxiety disorders -- Chapter 10. Immune-kynurenine pathways and the gut-microbiota-brain axis in anxiety disorders -- Chapter 11. Experimental anxiety model for anxiety disorders: relevance to drug discovery -- Part 3. Diagnostic and clinical Issues -- Chapter 12. Anxiety disorders in DSM-5: changes, controversies, and future directions -- Chapter 13. Biological markers to differentiate the type of anxiety disorders -- Chapter 14. Comorbid anxiety and depression: clinical and conceptual consideration, transdiagnostic treatment -- Chapter 15. Anxiety disorders and medical comorbidity: treatment implications -- Part 4. Therapeutic Issues -- Chapter 16. Biofeedback and Neurofeedback for Anxiety Disorders: A Quantitative and Qualitative Systematic Review -- Chapter 17. Cognitive Behavioral Therapy, Mindfulness-Based Cognitive Therapy and Acceptance Commitment Therapy for Anxiety Disorders: Integrating Traditional with Digital Treatment Approaches -- Chapter 18. Neurostimulation in anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder -- Chapter 19. Current and novel psychopharmacological drugs for anxiety disorders -- Chapter 20. Role of benzodiazepines in anxiety disorders -- Chapter 21. Virtual Reality for Anxiety Disorders: Rethinking a Field in Expansion -- Chapter 22. Current research on complementary and alternative medicine (CAM) in the treatments of anxiety disorders: evidence based review -- Chapter 23. Contemporary Psychodynamic Approaches to Treating Anxiety: Theory, Research, and Practice -- Chapter 24. Well-being therapy in anxiety disorders -- Part 5. Anxiety and precision psychiatry -- Chapter 25. Personalized clinical approaches to anxiety disorders -- Chapter 26. The role of hormonal and reproductive status in the treatment of anxiety disorders in women -- Chapter 27. Risk factors and prevention strategies for anxiety disorders in childhood and adolescence -- Chapter 28. Anxiety disorders in the elderly.
    Abstract: This book reviews all important aspects of anxiety disorders with the aim of shedding new light on these disorders through combined understanding of traditional and novel paradigms. The book is divided into five sections, the first of which reinterprets anxiety from a network science perspective, examining the altered topological properties of brain networks in anxiety disorders. The second section discusses recent advances in understanding of the neurobiology of anxiety disorders, covering, for example, gene-environmental interactions and the roles of neurotransmitter systems and the oxytocin system. A wide range of diagnostic and clinical issues in anxiety disorders are then addressed, before turning attention to contemporary treatment approaches in the context of novel bio-psychosocial-behavioral models, including bio- and neurofeedback, cognitive behavioral therapy, neurostimulation, virtual reality exposure therapy, pharmacological interventions, psychodynamic therapy, and CAM options. The final section is devoted to precision psychiatry in anxiety disorders, an increasingly important area as we move toward personalized treatment. Anxiety Disorders will be of interest for all researchers and clinicians in the field.
    Type of Medium: Online Resource
    Pages: VII, 576 p. 32 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813297050
    Series Statement: Advances in Experimental Medicine and Biology, 1191
    URL: https://doi.org/10.1007/978-981-32-9705-0
    DOI: 10.1007/978-981-32-9705-0
    DDC: 612.8
    Language: English
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  • 8
    Online Resource
    Online Resource
    Major Depressive Disorder : Rethinking and Understanding Recent Discoveries (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Neurosciences. ; Psychiatry. ; Neuroscience. ; Psychiatry.
    Description / Table of Contents: Section I. Re-thinking depression from a network perspective -- Chapter 1. Phenotype network and brain structural covariance network of major depression -- Chapter 2. Task MRI-based functional brain network of major depression -- Chapter 3. White matter-based structural brain network of major depression -- Chapter 4. The application of a machine learning-based brain MRI approach in major depression -- Chapter 5. Resting state functional MRI in major depression -- Chapter 6. Development of neuroimaging–based biomarkers in depressive disorder -- Section II. Current diagnostic and neurobiological issues -- Chapter 7. Challenges and strategies for current classifications of depressive disorders: proposal for future diagnostic standards -- Chapter 8. Epigenetics: a missing link between early life stress and depression -- Chapter 9. Glia- neuron communications and gut-brain axis in depression -- Chapter 10. Apoptosis and proliferation markers in major depression -- Chapter 11. A load to find clinically useful biomarkers for depression -- Chapter 12. Pharmacogenomic tests for diagnosis and treatment prediction in depression -- Section III. Current specific treatments for depression -- Chapter 13. Biofeedback and neurofeedback for depression: a critical review -- Chapter 14. Cognitive behavioral therapy and mindfulness based cognitive therapy for depressive disorders -- Chapter 15. Acceptance Commitment Therapy (ACT) for major depressive disorder -- Chapter 16. Neurostimulation therapies in depressive disorders -- Chapter 17. Ketamine in major depression : New rapid antidepressant -- Chapter 18. Psychodynamic therapy in depressive disorders -- Chapter 19. Well-being therapy in depressive disorders -- Chapter 20. Complementary and alternative medicine in the treatments of depressive disorders -- Chapter 21. Current psychopharmacology algorithm for major depressive disorder -- Section IV. Promising future treatments for depression -- Chapter 22. Novel psychopharmacology for depressive disorders -- Chapter 23. Cannabinoid agents for depressive disorders -- Chapter 24. Virtual Reality for the treatment of depressive disorders -- Chapter 25. Epigenetic Therapy in depressive disorders -- Chapter 26. Induced pluripotent stem (iPS) cells technology: potential therapeutic targets for depression -- Chapter 27. Vaccination and immunotherapy for major depression -- Chapter 28. Psychedelic Medicines in major depression: progress and future challenges -- Chapter 29. Precision Psychiatry: Biomarker guided Tailored Therapy for Effective Treatment and Prevention in major depression. .
    Abstract: This book reviews all aspects of major depressive disorder (MDD), casting light on its neurobiological underpinnings and describing the most recent advances in management. The book is divided into four sections, the first of which discusses MDD from a network science perspective, highlighting the alterations in functional and structural connectivity and presenting insights achieved through resting state functional MRI and the development of neuroimaging-based biomarkers. The second section examines important diagnostic and neurobiological issues, while the third considers the currently available specific treatments for MDD, including biofeedback, neurofeedback, cognitive behavioral therapy, acceptance and commitment therapy, neuromodulation therapy, psychodynamic therapy, and complementary and alternative medicine. A concluding section is devoted to promising emerging treatments, from novel psychopharmacological therapies through to virtual reality treatment, immunotherapy, biomarker-guided tailored therapy, and more. Written by leading experts from across the world, the book will be an excellent source of information for both researchers and practitioners.
    Type of Medium: Online Resource
    Pages: XI, 563 p. 30 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813360440
    Series Statement: Advances in Experimental Medicine and Biology, 1305
    URL: https://doi.org/10.1007/978-981-33-6044-0
    DOI: 10.1007/978-981-33-6044-0
    DDC: 612.8
    Language: English
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  • 9
    Online Resource
    Online Resource
    Advanced Techniques of Endoscopic Lumbar Spine Surgery (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Nervous system Surgery. ; Orthopedic surgery. ; Neurosurgery. ; Surgical Orthopedics.
    Description / Table of Contents: 1. Special issue of endoscopic spine surgery -- (1) Paradigm shifting of spinal endoscopic approach -- (2) Nomenclature of endoscopic surgery -- (3) Learning curve of endoscopic lumbar discectomy -- 2. Lumbar central stenosis -- (1) Full endoscopic posterior approach: in and out -- (2) Full endoscopic posterior approach: out and in -- (3) Biportal endoscopic approach -- 3. Lumbar foraminal stenosis -- (1) Full endoscopic contralateral approach -- (2) Full endoscopic transforaminal approach -- (3) Full endoscopic paraspinal approach -- (4) Biportal endoscopic contralateral approach -- (5) Biportal endoscopic paraspinal approach -- 4. Lumbar disc herniation -- (1) Full endoscopic approach with foraminoplasty -- (2) Full endoscopic transpedicular approach -- (3) Biportal endoscopic approach -- 5. Endoscopic lumbar interbody fusion -- (1) Endoscopic OLIF -- (2) Endoscopic LIF uniportal -- (3) Endoscopic LIF biportal.
    Abstract: This book is a superbly illustrated guide to the latest endoscopic approaches employed in surgery to the lumbar spine. In the past, spinal endoscopic surgeries have been performed mainly in the treatment of lumbar disc herniation, but indications have now expanded owing to breakthroughs in surgical methods and instruments. Furthermore, in addition to the traditional percutaneous transforaminal approach, various other approaches are now feasible, including the posterior, paraspinal, transpedicular, and contralateral. This book describes and illustrates the full array of approaches in indications including lumbar central stenosis, lumbar foraminal stenosis, and lumbar disc herniation. Detailed guidance is also provided on endoscopic lumbar interbody fusion, covering the oblique, uniportal, and biportal approaches. Supplementary surgical videos further facilitate understanding and execution of the described procedures. Written by expert spinal endoscopy surgeons with extensive practical experience and a record of academic achievement, the book will be an ideal aid for spine surgeons at all levels of experience.
    Type of Medium: Online Resource
    Pages: XVIII, 172 p. 162 illus., 137 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811582530
    URL: https://doi.org/10.1007/978-981-15-8253-0
    DOI: 10.1007/978-981-15-8253-0
    DDC: 617.48
    Language: English
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  • 10
    Online Resource
    Online Resource
    Glycosphingolipids Signaling (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Molecular genetics. ; Cancer. ; Genetics. ; Biochemistry. ; Biological transport. ; Cell membranes. ; Molecular Genetics. ; Cancer Biology. ; Genetics and Genomics. ; Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. Glycosphingolipids (GSLs) -- 2. Mammal GSL synthesis via ER and Golgi network -- 3. The GSL dependent signaling -- 4. Viral protein interaction with host cells GSLs -- 5. Bacterial toxin protein interaction with host cells GSL -- 6. GSL signaling regulation.
    Abstract: This book presents the latest knowledge and the most recent research results on glycosphingolipid (GSL)-mediated signaling. GSLs are important constituents of the plasma membrane that exert their distinct functions through binding to certain functional proteins. They play a role in various human diseases and also function as human alloantigens. Cellular GSLs are associated with many biological functions such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein–carbohydrate or carbohydrate–carbohydrate interactions. This book opens by providing the key background on GSL glycan–receptor interactions and mammalian GSL synthesis. Up-to-date information is then presented on all aspects of GSL-dependent signaling. Viral protein and bacterial toxin protein interactions with host cell GSLs are examined in depth, and the concluding chapter is devoted to signaling regulation. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.
    Type of Medium: Online Resource
    Pages: XVII, 181 p. 30 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811558078
    URL: https://doi.org/10.1007/978-981-15-5807-8
    DOI: 10.1007/978-981-15-5807-8
    DDC: 572.8
    Language: English
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