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  • 11
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Genetics. ; Medical genetics. ; Biology. ; Membranes (Biology). ; Biological transport. ; Cell membranes. ; Genetics and Genomics. ; Medical Genetics. ; Biological Sciences. ; Biological Membranes. ; Membrane Trafficking.
    Description / Table of Contents: Part 1. Glycans in innate immunity of dendritic cells -- Chapter 1) Historical expansion of defense system -- Chapter 2) Columbus era to modern revolution in immunological defense system -- Chapter 3) Historical profile of defense constituents and progress in innte immune repertoire -- Chapter 4) The outline of innate immunity -- Chapter 5) Autophagy from microbial invaders and self-associated molecular patterns (SAMPs) of innate immune cells -- Part 2. Dendritic cells (DCs) -- Chapter 6) General biology of DCs -- Chapter 7) Classification and different function of DCs -- Chapter 8) Glycan biosynthesis in eukaryotes -- Chapter 9) Glycans in cell recognition and evolutionary adaptation in organisms -- Chapter 10) Changes in glycan structure involve in co-regulated expression of glycan-binding lectin counterparts -- Chapter 11) Evolution of lectin: alternative splicing contributes to variation for glycan binding receptors -- Chapter 12) Glycan regulation of NK cell receptors -- Chapter 13) Carbohydrate recognition of target antigens by DCs during infection and inflammation -- Chapter 14) Glycan-specific trafficking receptors in DCs maturation -- Chapter 15) Glycan ligands in trafficking of DC migration -- Chapter 16) Chemokine receptors in DCs trafficking -- Chapter 17) Glycan structure-recognizing selectins in DC-endothelium interaction during infection and inflammation -- Chapter 18) Glycans activate the innate immune system -- Chapter 19) Innate immune lectin receptors of Siglec, DC-SIGN, Galectin and TLR in DCs -- Chapter 20) Galectins -- Chapter 21) DC-specific ICAM-3-grabbing non-integrin, DC-SIGNB (CD209) -- Chapter 22) Other DCs-derivd receptors -- Chapter 23) Toll-like receptors (TLRs) -- Chapter 24) CD33 and CD33-related Siglecs in pathogen recognition and endocytosis of DC in the innate immune system -- Chapter 25) Pathogenic suppression of the pathogen-specific host immune response -- Chapter 26) DCs tumor immunotherapy through sialyl binding of DCs to T cells.
    Abstract: This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein–carbohydrate or carbohydrate–carbohydrate interactions. This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapter is devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.
    Type of Medium: Online Resource
    Pages: XIX, 656 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811690815
    DDC: 576.5
    Language: English
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  • 12
    Keywords: Sustainability. ; Digital humanities. ; Internet of things. ; Sociology, Urban. ; Urban economics. ; Architecture. ; Sustainability. ; Digital Humanities. ; Internet of Things. ; Urban Sociology. ; Urban Economics. ; Cities, Countries, Regions.
    Description / Table of Contents: Introduction - The digital polis and its practices: Beyond gated communities -- Digital polis and the ‘safe’ feminism: Focusing on the strategies of direct punishment and gated community -- Toward digital polis: Gendered data (in)justice and data activism in South Korea -- Subjection or subjectification: representation of 'networked individuals' in Korean web novels -- Digital polis and urban commons: Justice beyond the gated community -- Production and reproduction of space and culture in the virtual realm: Gated communities as the imaginary, intermediary and real spaces -- The ghettoised city and the affect of anxiety in Park Wan-soe’s ‘apartment novels’ -- Spatial and digital fortressing of apartment complexes in Seoul: Two case studies -- Inclusion, exclusion, and participation in digital polis: Double-edged development of poor urban communities in alternative smart city-making -- Online-based food hubs for community health and well-being: Performance in practice and its implications for urban design -- Third places: The social infrastructure of the smart city. .
    Abstract: This edited collection provides an alternative discourse on cities evolving with physically and virtually networked communities—the ‘digital polis’—and offers a variety of perspectives from the humanities, media studies, geography, architecture, and urban studies. As an emergent concept that encompasses research and practice, the digital polis is oriented toward a counter-mapping of the digital cityscape beyond policing and gatekeeping in physical and virtual gated communities. Considering the digital polis as offering potential for active support of socially just and politically inclusive urban circumstances in ways that mirror the Greek polis, our attention is drawn towards the interweaving of the development of digital technology, urban space, and social dynamics. The four parts of this book address the formation of technosocial subjectivity, real-and-virtual combined urbanity, the spatial dimensions of digital exclusion and inclusion, and the prospect of emancipatory and empowering digital citizens. Individual chapters cover varied topics on digital feminism, data activism, networked individualism, digital commons, real-virtual communalism, the post-family imagination, digital fortress cities, rights to the smart city, online foodscapes, and open-source urbanism across the globe. Contributors explore the following questions: what developments can be found over recent decades in both physical and virtual communities such as cyberspace, and what will our urban future be like? What is the ‘digital polis’ and what kinds of new subjectivity does it produce? How does digital technology, as well as its virtuality, reshape the city and our spatial awareness of it? What kinds of exclusion and cooperation are at work in communities and spaces in the digital age? Each chapter responds to these questions in its own way, navigating readers through routes toward the digital polis. Chapter "Introduction - The digital polis and its practices: Beyond gated communities" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 208 p. 32 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811996856
    Series Statement: Advances in 21st Century Human Settlements,
    DDC: 304.2
    Language: English
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