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  • 1
    Online Resource
    Online Resource
    Heparanase : From Basic Research to Clinical Applications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Abstract: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Type of Medium: Online Resource
    Pages: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345211
    Series Statement: Advances in Experimental Medicine and Biology, 1221
    URL: https://doi.org/10.1007/978-3-030-34521-1
    DOI: 10.1007/978-3-030-34521-1
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Biorefinery: A Sustainable Approach for the Production of Biomaterials, Biochemicals and Biofuels (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Sustainability. ; Biomaterials. ; Biotechnology. ; Sustainability. ; Biomaterials.
    Description / Table of Contents: Chapter 1_Biomass to liquid fuels: Recent trends in techniques in catalytic conversions -- Chapter 2_Towards sustainable production of hydrogen and biogas from biomass residues -- Chapter 3_ Biorefinery for biofuel production: A Case Study -- Chapter 4_Techno economic analysis and profitability analysis of biofuel production -- Chapter 5_Life cycle analysis and environmnetal impact of bio fuel production -- Chapter 6_Valorization of non lignocellulosic bio waste for BioChemicals -- Chapter 7_State of art technologies for production of biochemicals from biomass -- Chapter 8_Nutraceuticals functional foods and specialty chemicals -- Chapter 9_Technoeconomical analysis of BioChemical production: A Case study -- Chapter 10_Life cycle assessment and sustainability for production of pectin -- Chapter 11_Production of biofertilizers from agro residue: sustainability issues and challenges -- Chapter 12_Utilization of activated carbon obtained from biomass in waste water treatment -- Chapter 13_Sustanability and life cycle assessment of nano-materials from biomass -- Chapter 14_Biorefinery approach for production of enzymes from fruit peel waste -- Chapter 15_Production of Biomaterials: A Case study.
    Abstract: This book discusses recent trends and concepts in the field of biorefinery. It discusses optimal and economic strategies for converting biomass to value-added products to maximize profits with minimal environmental impact with a sustainability approach. The chapters of the book are focused on the current technologies, techno-economical aspects, life cycle assessment, and case studies. The book is divided into three sections; the first section presents strategies for the production of biofuels like bioethanol, biomethane, biohydrogen, bio-oil, gasification, etc., from the biomass in a sustainable way. The second sections review the extraction of bioactive chemicals, phenolic antioxidants, enzymes, and carboxylic acid from the biomass residue. The last section examines the utilization of biomass for the production of bioactive materials, including biofertilizers, bioadsorbents, activated carbon, nano-materials, and pigments. This book explores the relation between biofuels and the sustainable development goals (SDGs) 7.
    Type of Medium: Online Resource
    Pages: XII, 409 p. 56 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811974816
    URL: https://doi.org/10.1007/978-981-19-7481-6
    DOI: 10.1007/978-981-19-7481-6
    DDC: 660.6
    Language: English
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  • 3
    Online Resource
    Online Resource
    The Extracellular Matrix and the Tumor Microenvironment (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Clinical biochemistry. ; Cancer Biology. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.
    Abstract: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: X, 494 p. 40 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030997083
    Series Statement: Biology of Extracellular Matrix, 11
    URL: https://doi.org/10.1007/978-3-030-99708-3
    DOI: 10.1007/978-3-030-99708-3
    DDC: 571.978
    Language: English
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  • 4
    Online Resource
    Online Resource
    Emerging Threats of Synthetic Biology and Biotechnology : Addressing Security and Resilience Issues (2021)
    Dordrecht :Springer Netherlands :
    Details
    Keywords: Biotechnology. ; Environmental engineering. ; Bioremediation. ; Security, International. ; Criminology. ; Environmental Law. ; Biotechnology. ; Environmental Engineering/Biotechnology. ; International Security Studies. ; Crime Control and Security. ; Biotechnology. ; Environmental Law.
    Description / Table of Contents: Chapter 1: Biosecurity for Synthetic Biology and Emerging Biotechnologies: Critical Challenges for Governance -- Chapter 2: Emerging Biosecurity Threats and Responses: A Review of Published and Gray Literature -- Chapter 3: Opportunities, Challenges, and Future Considerations for Top-Down Governance for Biosecurity and Synthetic Biology -- Chapter 4: Biological standards and biosecurity: The unexplored link -- Chapter 5: Responsible Governance of Biosecurity in Armenia -- Chapter 6: Addressing Emerging Synthetic Biology Threats: The Role of Education and Outreach in Fostering Effective Bottom-Up Grassroots Governance -- Chapter 7: Cybersecurity and Public Health in the Age of COVID-19 -- Chapter 8: Synthetic Biology Brings New Challenges to Managing Biosecurity and Biosafety -- Chapter 9: Emerging Biotechnology and Information Hazards -- Chapter 10: Technical Aspects of Biosecurity: Screening Guidance, Attribution, and Traceability -- Chapter 11: The Soil Habitat and Considerations for Synthetic Biology -- Chapter 12: Foresight in Synthetic Biology and Biotechnology Threats -- Chapter 13: Predicting Biosecurity Threats: Deployment and Detection of Biological Weapons -- Chapter 14: Promoting Effective Biosecurity Governance: Using Tripwires to Anticipate and Ameliorate Potentially Harmful Development Trends. .
    Abstract: Synthetic biology is a field of biotechnology that is rapidly growing in various applications, such as in medicine, environmental sustainability, and energy production. However these technologies also have unforeseen risks and applications to humans and the environment. This open access book presents discussions on risks and mitigation strategies for these technologies including biosecurity, or the potential of synthetic biology technologies and processes to be deliberately misused for nefarious purposes. The book presents strategies to prevent, mitigate, and recover from ‘dual-use concern’ biosecurity challenges that may be raised by individuals, rogue states, or non-state actors. Several key topics are explored including opportunities to develop more coherent and scalable approaches to govern biosecurity from a laboratory perspective up to the international scale and strategies to prevent potential health and environmental hazards posed by deliberate misuse of synthetic biology without stifling innovation. The book brings together the expertise of top scholars in synthetic biology and biotechnology risk assessment, management, and communication to discuss potential biosecurity governing strategies and offer perspectives for collaboration in oversight and future regulatory guidance.
    Type of Medium: Online Resource
    Pages: XV, 225 p. 15 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789402420869
    Series Statement: NATO Science for Peace and Security Series C: Environmental Security,
    URL: https://doi.org/10.1007/978-94-024-2086-9
    DOI: 10.1007/978-94-024-2086-9
    DDC: 660.6
    Language: English
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  • 5
    Online Resource
    Online Resource
    Biotechnology for Environmental Protection (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Bioremediation. ; Microbial ecology. ; Biotechnology. ; Environmental Biotechnology. ; Environmental Microbiology.
    Description / Table of Contents: 1 Environmental pollutants: metal(loid)s and radionuclides -- 2 Environmental pollutants: organic and emerging contaminants -- 3 Biosorption, Bioaccumulation And Biodegradation – A Sustainable Approach For Management Of Environmental Contaminants -- 4 Bioremediation technologies for the treatment of water contaminated by organic and inorganic contaminants -- 5 Biological treatment of volatile organic compounds (VOCs) and odorous compounds -- 6 Biological treatment of endocrine-disrupting chemicals (EDCs) -- 7 Biological Treatment Of Pharmaceuticals And Personal Care Products (Ppcps) -- 8 Genetic engineering strategies and degradation of pollutants using genetically engineered microbes (GEMs) -- 9 Biogenic synthesis of nanoparticles and its application in wastewater treatment -- 10 BioTechnological approach for treatment of sludge from municipal and industrial wastewater treatment plant -- 11 Microwave Assisted Chemically Modified Biochar For The Sequestration Of Emerging Contaminants.
    Abstract: This book covers broader application of biotechnology for the protection of environment through different bioremediation and biodegradation techniques developed for removal of environmental contaminants including the recently discovered contaminants. The book offers a comprehensive overview of environmental pollutants including their fate, behavior, environmental and associated health risks. It is useful reading material for postgraduate and graduate students of environmental biotechnology, environmental microbiology and ecology. Young researchers also find the chapters useful understanding the latest developments.
    Type of Medium: Online Resource
    Pages: X, 310 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811949371
    URL: https://doi.org/10.1007/978-981-19-4937-1
    DOI: 10.1007/978-981-19-4937-1
    DDC: 660.6
    Language: English
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