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  • Bücher  (4)
  • 571.978  (2)
  • 579.2  (2)
  • 1
    Online-Ressource
    Online-Ressource
    History of Arbovirology: Memories from the Field : Volume I: Personal Reflections (2023)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Virology. ; Medicine Research. ; Biology Research. ; Life sciences. ; Virology. ; Biomedical Research. ; Life Sciences.
    Beschreibung / Inhaltsverzeichnis: 1. The Quest for Excellence and the Challenge of Gender Equality in Arbovirology: A Celebration of Women’s Contributions to the Field -- 2. Serendipity and Arboviruses -- 3. The Tapestry of Life: Weaving an Arbovirologist -- 4. Arbovirus and Viral Hemorrhagic Fevers Research Inception in Central and West Africa -- 5. From Bwamba to the Present: The Changing Forest of Arbovirology -- 6. Fighting Dengue, Chikungunya and Japanese Encephalitis -- 7. Chronicles of Hantaviruses: Foundations of Epidemiology and Ecology -- 8. Yellow Fever and Other Viruses in West Africa -- 9. The “Golden Age” of Arbovirology, 1950-1969 -- 10. Twenty-Seven Years of Field Studies on Dengue and Aedes Aegypti in Latin America -- 11. 50 Years of Medical Entomology: Miscellaneous Interesting Findings -- 12. Remembrances of Virology Past -- 13. An Overview of Arbovirology in São Paulo State, Southeastern Brazil: Highlighting the Virus Research Center in Ribeirão Preto City -- 14. An Unplanned Career in Arbovirology.
    Kurzfassung: These books bring together a panel of expert arbovirologists who recall the history of arbovirology from very personal perspectives. In these timely volumes, the authors describe seminal moments in their experiences in the field and how they integrated these findings with lab studies to further clarify the ecology and epidemiology of diverse arboviruses. Authors identify the most pressing questions that remain to be answered, providing a basis for current research and a stimulus to engage those entering the field. Over the last 20 years a generational gap has developed between the giants of arbovirus research and discovery and the new generation. This gap developed due to an ebbing of training and investment in passing the scepter to the next generation, leading to a lack of continuity among the generations that threatens to derail the rich history of virus discovery, field epidemiology and understanding of the richness of diversity that surrounds us. This lack of continuity may have immediate and disastrous consequences for public health when yet to be discovered arboviruses emerge. The purpose of these books is to bridge this gap by providing a historical context for the work being done today and provide continuity between the generations. To this end, the books provide a narrative of the thrill of scientific discovery and excitement of field adventures and lab studies of that generation -- essential reading for every arbovirologist, and highly recommended for all virologists and public health officials, as well as those students considering future research options. Volume I consists of the personal reflections of arbovirologists who played a significant role in the advancement of arbovirology across the globe. Volume II transitions to descriptions of region-specific and virus family-specific perspectives of arbovirology, as well as recollections of the early events of molecular advances and pathogenesis studies.
    Materialart: Online-Ressource
    Seiten: XX, 542 p. 258 illus., 200 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031219993
    URL: https://doi.org/10.1007/978-3-031-21999-3
    DOI: 10.1007/978-3-031-21999-3
    DDC: 579.2
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    E-BOOKS (AWI ONLY)
  • 2
    Online-Ressource
    Online-Ressource
    Heparanase : From Basic Research to Clinical Applications (2020)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Kurzfassung: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Materialart: Online-Ressource
    Seiten: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Ausgabe: 1st ed. 2020.
    ISBN: 9783030345211
    Serie: Advances in Experimental Medicine and Biology, 1221
    URL: https://doi.org/10.1007/978-3-030-34521-1
    DOI: 10.1007/978-3-030-34521-1
    DDC: 571.978
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    E-BOOKS (AWI ONLY)
  • 3
    Online-Ressource
    Online-Ressource
    History of Arbovirology: Memories from the Field : Volume II: Virus Family and Regional Perspectives, Molecular Biology and Pathogenesis (2023)
    Cham :Springer Nature Switzerland :
    Details
    Schlagwort(e): Virology. ; Medicine Research. ; Biology Research. ; Virology. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: 1. RNAi: The Mosquito Defense System Against Damage Due to Arbovirus Infection -- 2. A First-hand Account of the Progression of Flavivirus Molecular Biology -- 3. Sindbis Virus: Studies of Alphavirus Pathogenesis -- 4. Mechanisms of Tick-borne Virus Transmission -- 5. The Use of Humanized Mice to Understand Arbovirus Pathogenesis -- 6. Molecular Biology of Arboviruses -- 7. Mosquito-Virus-Environment Interactions -- 8. A Brief Historical Overview of the Discovery of Arboviruses in the USSR and Russia -- 9. The History of the Emergence of La Crosse Encephalitis Virus in the Driftless Area of the United States: A Mosquito Runs Through It! -- 10. “It Isn’t Going to Reach Here”: Venezuelan Equine Encephalitis in Texas, 1971 -- 11. History of Arbovirology in Canada -- 12. Arbovirus Discovery in the British Empire: India and Africa, c. 1880-1960 -- 13. History of Arbovirology in Japan -- 14. Ockelbo Disease in Sweden: Unraveling the Epidemiology, Ecology, and Evolution of Sindbis Virus -- 15. Human Arboviruses in Eastern, South-Eastern, and Southern Asia: A Brief History of Their Isolation and Characteristics -- 16. History of Arbovirus Research in Kenya -- 17. Vector Studies in the Amazon Basin Region of Peru -- 18. Zika Virus Studies in West Africa -- 19. Hemorrhagic Fevers -- 20. Chronicles of Hantaviruses: Virus Discovery to Vaccine Candidates -- 21. A History of Tick-Borne Encephalitis and Its Virus -- 22. Kyasanur Forest Disease -- 23. The Discovery of Insect-Specific Viruses in Australia: Mossies, Old Mates, and New Methods.
    Kurzfassung: These books bring together a panel of expert arbovirologists who recall the history of arbovirology from very personal perspectives. In these timely volumes, the authors describe seminal moments in their experiences in the field and how they integrated these findings with lab studies to further clarify the ecology and epidemiology of diverse arboviruses. Authors identify the most pressing questions that remain to be answered, providing a basis for current research and a stimulus to engage those entering the field. Over the last 20 years a generational gap has developed between the giants of arbovirus research and discovery and the new generation. This gap developed due to an ebbing of training and investment in passing the scepter to the next generation, leading to a lack of continuity among the generations that threatens to derail the rich history of virus discovery, field epidemiology and understanding of the richness of diversity that surrounds us. This lack of continuity may have immediate and disastrous consequences for public health when yet to be discovered arboviruses emerge. The purpose of these books is to bridge this gap by providing a historical context for the work being done today and provide continuity between the generations. To this end, the books provide a narrative of the thrill of scientific discovery and excitement of field adventures and lab studies of that generation -- essential reading for every arbovirologist, and highly recommended for all virologists and public health officials, as well as those students considering future research options. Volume I consists of the personal reflections of arbovirologists who played a significant role in the advancement of arbovirology across the globe. Volume II transitions to descriptions of region-specific and virus family-specific perspectives of arbovirology, as well as recollections of the early events of molecular advances and pathogenesis studies.
    Materialart: Online-Ressource
    Seiten: XX, 530 p. 171 illus., 121 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031220036
    URL: https://doi.org/10.1007/978-3-031-22003-6
    DOI: 10.1007/978-3-031-22003-6
    DDC: 579.2
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    E-BOOKS (AWI ONLY)
  • 4
    Online-Ressource
    Online-Ressource
    The Extracellular Matrix and the Tumor Microenvironment (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Cancer. ; Cytology. ; Clinical biochemistry. ; Cancer Biology. ; Cell Biology. ; Medical Biochemistry.
    Beschreibung / Inhaltsverzeichnis: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.
    Kurzfassung: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Materialart: Online-Ressource
    Seiten: X, 494 p. 40 illus., 34 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030997083
    Serie: Biology of Extracellular Matrix, 11
    URL: https://doi.org/10.1007/978-3-030-99708-3
    DOI: 10.1007/978-3-030-99708-3
    DDC: 571.978
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    E-BOOKS (AWI ONLY)
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