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  • 1
    Keywords: Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Abstract: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Type of Medium: Online Resource
    Pages: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345211
    Series Statement: Advances in Experimental Medicine and Biology, 1221
    DDC: 571.978
    Language: English
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  • 2
    Keywords: Cancer. ; Cytology. ; Clinical biochemistry. ; Cancer Biology. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.
    Abstract: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: X, 494 p. 40 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030997083
    Series Statement: Biology of Extracellular Matrix, 11
    DDC: 571.978
    Language: English
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  • 3
    Keywords: Environmental management. ; Operations research. ; Environmental health. ; Environmental monitoring. ; Environmental Management. ; Operations Research and Decision Theory. ; Environmental Health. ; Environmental Monitoring.
    Description / Table of Contents: The Classic Challenge of Good Decision Making -- About Expertise Problems: Decision Making Challenges in a Contentious Environment -- Actors and Experts in the Decision Making Process -- Critical Challenges and Difficulties in Safety, Security, Environment and Health: Why are we often so bad at managing SSEH Problems?- Ethics and Analytics as Key Drivers of Good Decisions -- Solving Problems in SSEH: The Use of Decision Support Tools -- Decision Making, ELECTRE, and SSEH -- Navigating Decisions in a 21st Century World -- References.
    Abstract: This book explores the challenges that confront leaders in government and industry when making decisions in the areas of environmental health and safety. Today, decision making demands transparency, robustness, and resiliency. However thoughtfully they are devised, decisions made by governments and enterprises can often trigger immediate, passionate public response. Expertise Under Scrutiny shows how leaders can establish organizational decision making processes that yield valid, workable choices even in fast-changing and uncertain conditions. The first part of the book examines the organizational decision making process, describing the often-contentious environment in which important environmental health and safety decisions are made, and received. The authors review the roles of actors and experts in the decision making process. The book goes on to address such topics as: · The roles of actors and experts in the decision making process · Ethics and analytics as drivers of good decisions · Why managing problems in safety, security, environment, and health Part II offers an outline for adopting a formal decision support structure, including the use of decision support tools. It includes a chapter devoted to ELECTRE (ELimination and Choice Expressing Reality), a multi-criteria decision analysis system. The book concludes with an insightful appraisal and analysis of the expertise, structure and resources needed for navigating well-supported, risk-informed decisions in our 21st Century world. Expertise Under Scrutiny benefits a broad audience of students, academics, researchers, and working professionals in management and related disciplines, especially in the field of environmental health and safety.
    Type of Medium: Online Resource
    Pages: XVI, 168 p. 45 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030205324
    Series Statement: Risk, Systems and Decisions,
    DDC: 333.7
    Language: English
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  • 4
    Keywords: Environment. ; Environmental management. ; Environmental monitoring. ; Environmental chemistry. ; Environmental Sciences. ; Environmental Management. ; Environmental Monitoring. ; Environmental Chemistry. ; Environmental Monitoring.
    Description / Table of Contents: 1 Climate resilience and Environmental Sustainability Approaches - An Introduction -- Part 1 -- Climate Change, Mitigation, and Sustainable -- 2 Progress in Climate Change Downscaling Simulations in Southeast Asia -- 3 Climate Change Signatures over Schirmacher Oasis, Antarctica -- 4 REDD+ in Indian context: Planning and Implementation Scenario -- 5 Climate Change Impacts, Vulnerability and Mitigation in the Indian Ocean Region: Policy Suggestions -- 6 Climate change, Agriculture adaptation and Sustainability -- 7 Enhancing climate service delivery mechanisms in agriculture sector to cope with climate change -- 8 Agrometeorological Services for Climate Resilient Agriculture -- 9 Microbial diversity and Multifunctional microbial biostimulants for Agricultural Sustainability -- 10 Adoption of Vertical Farming Technique for Sustainable Agriculture -- Part 2 -- Environmental Sustainability -- (Alternate Energy, Ecofriendly Waste Management and Sustainable Approaches) -- 11 Sustainability of Biofuels: The dynamic nexus between CO2 emissions and bioenergy consumption in OECD Countries -- 12 Challenges and Solution for Renewable Energy (RE) Development in Uttarkahand, India -- 13 Integrated Wastewater Treatment and Energy Production using Microbial Fuel Cell Technology: A Sustainable Environment Management Approach -- 14 Carbon Footprinting: A Study of Plywood Industry in District Yamunanagar (India) -- 15 Ecofriendly Bioremediation Approach for Dye Removal from Wastewaters: Challenges and Prospects -- 16 Degradation and biotransformation of pentachlorophenol by microorganisms -- 17 Sustainable Solid Waste Management in India – Practices, Challenges and the Way Forward -- 18 Social Enterprises as an Emerging Platform in Waste Management -- 19 Understanding linkages between Sustainability and Traditional Ethnoecological Knowledge (TEK): A case study of Paudi Bhuyans in Northern Odisha, India -- 20 Achieving Sustainable Development Goals (SDGs): Challenges and Preparation in Bangladesh -- 21 Sustainable Health care under Ayushman Bharat Initiative in India: Role of Institutional CSR. .
    Abstract: The book is about climate resilience and environmental sustainability approaches, discussing knowledge at global level and the local challenges, presented by authors from various countries. Environmental sustainability is at stake and implications of climate change are clearly visible in most parts of the world. In the times of the prevailing global environmental crisis, this book discusses key issues of climate change and sustainable energy alternatives, waste management and development. It discusses climate change scenario using simulation models in various Asian countries, signatures of climate change in Antarctica, implications in the Indian Ocean and the Indian scenario of REDD+. A special focus has been given on building climate resilience in our agricultural ecosystems and sustainable agriculture. It discusses the prospects and challenges of renewable energy options including biofuels and energy from wastewaters, explores the technical aspects of eco-friendly bioremediation of pollutants, sustainable solid waste management practices and challenges, carbon footprints of industry, and emphasizes on the significance of combining traditional knowledge with modern technology with novel approaches including involvement of social enterprises and corporate social responsibility to achieve the Sustainable Development Goals. This is an important document for researchers and policy makers working in multidisciplinary fields of sustainability sciences.
    Type of Medium: Online Resource
    Pages: XVI, 415 p. 69 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811609022
    DDC: 333.7
    Language: English
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  • 5
    Keywords: Environment. ; Environmental Sciences.
    Description / Table of Contents: Looking back to the future: the clash of religion and secularism -- The roots of spirituality and religion in the Pacific islands region -- Religion as culture, religion for wellbeing -- Weaving worldviews: science and spirituality together -- Belief and action: a way forward -- Faith for survival.
    Abstract: This interdisciplinary book explores the science and spirituality nexus in the Pacific Islands Region and as such makes a critical contribution to sustainable climate change adaptation in Oceania. In addition to presenting case studies, literary analyses, field projects, and empirical research, the book describes faith-engaged approaches through the prism of: • Context: past, present, and future prospects • Theory: concepts, narratives, and theoretical frameworks • Practice: empirical research and praxis-informed case examples • Doctrine: scriptural contributions and perspectives • Engagement: enlisting religious stakeholders and constituencies Comprising peer-reviewed works by scholars, professionals, and practitioners from across Oceania, the book closes a critical gap in the literature and represents a groundbreaking contribution to holistic climate change adaptation in the Pacific Islands Region that is scientifically sound, spiritually attuned, locally meaningful, and contextually compelling.
    Type of Medium: Online Resource
    Pages: XIV, 391 p. 31 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030676025
    Series Statement: Climate Change Management,
    DDC: 333.7
    Language: English
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  • 6
    Keywords: Environmental management. ; Environmental geography. ; Environmental Management. ; Integrated Geography.
    Description / Table of Contents: Chapter 1 -- Shorebirds and Recreation in Coastal Zones (Greg D. Simpson) -- Chapter 2. Interrogating the Recreational Disturbance Literature (Greg D. Simpson) -- Chapter 3. Main Sources of Recreational Disturbance (Sumudu Marasinghe) -- Chapter 4. How Recreational Disturbances affect Coastal Birds? Some Case Studies from Sri Lanka (Sumudu Marasinghe) -- Chapter 5. Setting the Management and Research Agendas (David Newsome).
    Abstract: Much of that growing demand for coastal recreation and tourism has focused on countries in South and Southeast Asia in the tourism megaregion that this book refers to as Tropical Asia. As such, the recreational disturbance of shorebirds in Asia is a serious conservation issue, at a time when populations of both migratory and non-migratory species of shorebirds are threatened and declining because of the loss of coastal habitat and increased human disturbance. Despite global awareness about the impacts that the growth of coastal recreation and tourism across Tropical Asia is likely to be having on threatened and endangered migratory and resident shorebird species of the coastal zones of the East Asian– Australasian Flyway, less than 3% of the published peer-reviewed research into the recreational disturbance of shorebirds addresses coastal zones of Tropical Asia. This situation points to a significant knowledge gap regarding the impacts of human recreation on shorebirds in the Tropical Asian region. In contrast, almost three quarters of the peer-reviewed articles that report recreational disturbance research and management strategies focus on coastal zones in North America (36%), Oceania (20%), and Europe (20%). For those reasons, the quantitative systematic literature review and research case study from Sri Lanka reported in this book provide a call to action and recommendations for both management approaches grounded in the international literature and a research agenda that should be implemented in the coastal zones of Tropical Asia.
    Type of Medium: Online Resource
    Pages: XIII, 97 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031139680
    Series Statement: SpringerBriefs in Environmental Science,
    DDC: 333.7
    Language: English
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  • 7
    Keywords: Environmental management. ; Sustainability. ; Environment. ; Freshwater ecology. ; Marine ecology. ; Pollution. ; Environmental Management. ; Sustainability. ; Environmental Sciences. ; Freshwater and Marine Ecology. ; Pollution.
    Description / Table of Contents: 1. Restoration, construction and conservation of degrading wetlands: A step towards sustainable management practices -- 2. Phytoremediation and sustainable developmental policies and practices -- 3. Wetland as a sustainable reservoir of ecosystem services: Prospects of threat and conservation -- 4. Carbon sequestration by wetlands in the climate change scenario -- 5. Wetlands: A major natural source responsible for methane emissions -- 6. Wetland conservation and restoration of ecosystem services and halt biodiversity loss: An India Prospectives -- 7. Microbes biology: Microbes in wetland and bioprospection of microbes -- 8. Contribution of Microbes in the renovation of wetland -- 9. Phytoremediation: Role of Mycorrhiza in plant responses to Stress -- 10. Integrated approach for bioremediation and biofuel production using algae -- 11. Dual role of Microalgae: Phycoremediation coupled with biomass generation for biofuel production -- 12. Microalgae and microorganisms- important regulators of Carbon dynamics in wetland ecosystem -- 13. Bioremediation of heavy metals: A new approach to sustainable agriculture -- 14. Waste water treatment through Nannotechnology: Role and Perspects.
    Abstract: The risks and consequences of environmental change are increasing, leading to massive losses in terms of ecosystems and having a huge impact on human populations. As such, global thinkers, environmentalists, scientists and policy makers are focusing on finding solutions and ways to sustain life on Earth. Anthropogenic impacts on the climate system can only be mitigated by the restoration of existing natural resources and the sustainable development of the environment and society. This book discusses the potential of green technology in waste management, wetland restoration, presenting the latest developments in the field of bioenergy, green ecology, bioremediation and microbial management. Wetlands are one of Earth’s most important ecosystems, and they provide valuable services to human societies, such as minimizing the impacts of floods, acting as a carbon sink, and offering water purification as well as recreational opportunities. Wetlands may be natural or constructed, and the effectiveness of wetland services largely depends on the diversity of macrophytes affecting the algal production, plant biomass and nutrient status of the system. In addition, they are one of the richest microbial ecosystems on earth: the rhizosphere, soil and water interface enhances wetland services with implications ranging from phytoremediation to microbial bioprospection. However, in order to function properly, they need to be effectively redesigned, reengineered, protected and maintained. The book addresses the dynamic relation between three global concerns: environmental pollution, resource exploitation and sustainability. It describes the utilization of resources like wastes (municipal, industrial, agricultural, mine drainage, tannery, solid, and e waste), plants, algae and microbes for production of renewable biofuel, biofertilizers and other value added products to achieve the goal of sustainable development. The book also discusses the current and future trends in employing wetlands in improving water quality. In addition it presents the latest international research in the fields of wetland science, waste management, carbon sequestration and bioremediation. Highlighting a broad spectrum of topics and strategies for achieving a sustainable environment, the book offers researchers, students and academics insights into utilizing resources in a sustainable way.
    Type of Medium: Online Resource
    Pages: XV, 247 p. 32 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811376658
    DDC: 333.7
    Language: English
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  • 8
    Keywords: Environment. ; Climatology. ; Medical physics. ; Industrial management Environmental aspects. ; Environmental Sciences. ; Climate Sciences. ; Medical Physics. ; Corporate Environmental Management.
    Description / Table of Contents: Efficiency of hybrid process of coagulation/flocculation followed by membrane filtration for the treatment of synthetic vegetable oil refinery wastewater -- Fe/clay composite as catalysts for textile wastewater treatment -- Iron removal from groundwater by adsorption process onto activated carbon obtained from Pinus halepensis cone wastes -- Synthesis and characterization of activated carbon from Pinus halepensis cone wastes; Adsorption Prediction as a function of some physicochemical characteristics of activated carbons -- ADSORPTION OF INDUSTRIAL DYE BzR FROM AQUEOUS SOLUTION USING LOCAL MODIFIED CLAY -- Adsorption-desorption of Methylene blue by bentonite from aqueous solution -- Removal of dispersedye from aqueous solution by bottom ash -- Experimental study of the removal of Rhodamine B from aqueous solution by adsorption onto coffee waste -- Electrochemical impedance spectroscopy and adsorption study of carbon steel in 1M HCl solution containing 2-(2-Methoxybenzylidene) Hydrazine-1-Carbothioamide -- Adsorption efficiency of graphene oxide towards cyanine dyes with different alkyl chain lengths -- Cu(II) ions removal on functionalized cellulose beads from Tunisian almond (Prunus dulcis) shell -- Optimization of Cr(III) removal from a synthetic solution and a real tanning effluent by powdered marble using 3-level Box-Behnken design: thermodynamic, toxicity and regeneration studies -- Dynamics Modelling of Multicomponent Metal Ions Removal onto Low Cost Buckwheat Hulls -- Local Materials and Solid Waste (Sawdust) Valorization in The Treatment of Industrial synthetic water field -- Cationic dye removal using alginate-organobentonite composite beads.
    Abstract: This book includes over three hundred and seventy-five short papers presented during the second EMCEI, which was held in Sousse, Tunisia in October 2019. After the success of the first EMCEI in 2017, the second installment tackled emerging environmental issues together with new challenges, e.g. by focusing on innovative approaches that contribute to achieving a sustainable environment in the Mediterranean and surrounding regions and by highlighting to decision makers from related sectors the environmental considerations that should be integrated into their respective activities. Presenting a wide range of environmental topics and new findings relevant to a variety of problems in these regions, this volume will appeal to anyone working in the subject area and particularly to students interested in learning more about new advances in environmental research initiatives in view of the worsening environmental degradation of the Mediterranean and surrounding regions, which has made environmental and resource protection into an increasingly important issue hampering sustainable development and social welfare.
    Type of Medium: Online Resource
    Pages: LXXXIII, 2417 p. 786 illus., 620 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030512101
    Series Statement: Environmental Science,
    DDC: 333.7
    Language: English
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