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  • 1
    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy.
    Description / Table of Contents: Dedication -- Preface.-The carbonic anhydrases in health and disease -- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets -- Targeting carbonic anhydrases in vascular and pulmonary disease -- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema -- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders -- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes -- An overview of carbonic anhydrase-related neoplasms -- The carbonic anhydrase IX interactome and the regulation of cancer progression -- Carbonic anhydrase IX: current and emerging therapies -- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents -- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening -- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.
    Abstract: This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
    Type of Medium: Online Resource
    Pages: XII, 288 p. 38 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030795115
    Series Statement: Progress in Drug Research, 75
    DDC: 615
    Language: English
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  • 2
    Keywords: Sustainability. ; Human geography. ; Environmental policy. ; Physical geography. ; Sustainability. ; Human Geography. ; Environmental Policy. ; Physical Geography.
    Description / Table of Contents: Chapter1: Introduction: Localizing SDG Goals and empowering cities and communities in North America for sustainability -- SectionI: City & Regional Localization of SDGs -- Chapter2: Localizing the SGDs in Baltimore: Challenges and Opportunities of the USA Sustainable Cities Initiative -- Chapter3: Los Angeles: Measuring Its Ambition to Achieve the SDGs -- Chapter4: The Idea of Sustainability and the Houston Region -- SectionII: Programs and Tools to support the implementation of the SDGs -- Chapter5: Making the SDGs Relevant for Cities: Using the Community Capital Tool in British Columbia -- Chapter6: How Local Communities Can Align with United Nations Sustainable Development Goals: A Santa Cruz County Case Study -- SectionIII: Mobilizing Local SDG efforts across North America -- Chapter7: Top-down and Bottom-Up Approaches to the SDG-Monitoring Challenge -- Chapter8: Data for Good for All – Enabling All Communities to Track Progress Towards SDG Implementation -- SectionIV: Developing new methods and data to localize SDGs -- Chapter9: Helping the Neighborhood Create Indicators for Sustainable Housing Planning, Sustainable Development Goal #11 Sustainable Cities & Communities -- Chapter10: How the Youth Social Enterprise (YSE) Model Supports the Implementation of the Sustainable Development Goal #8 Economic Growth and Decent Work in American Cities -- SectionV: Goals, Targets and Indicators for Localizing SDGs in the US -- Chapter11: Proposed Local SDG Indicators for US Cities and Communities.
    Abstract: This volume presents North American best practices and perspectives on developing, managing and monitoring indicators to track development progress towards the Sustainable Development Goals (SDGs) in local communities and cities. In 4 main sections, the book presents and frames the many ways in which community indicator programs are either integrating or retooling to integrate the SDGs into their existing frameworks, or how they are developing new programs to track and report progress on the SDGs. This is the first volume that focuses on SDG adoption within the context of North Americans cities and communities, and the unique issues and opportunities prevalent in these settings. The chapters are developed by experienced academics and practitioners of community planning and sustainable development, and will add broad perspective on public policy, organizational management, information management and data visualization. This volume presents a case-study approach to chapters, offering lessons that can be used by three main audiences: 1) teachers and researchers in areas of urban, regional, and environmental planning, urban development, and public policy; 2) professional planners, decision-makers, and urban managers; and 3) sustainability activists and interested groups.
    Type of Medium: Online Resource
    Pages: VII, 160 p. 118 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030591731
    Series Statement: Sustainable Development Goals Series,
    DDC: 304.2
    Language: English
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  • 3
    Keywords: Human geography. ; Management. ; Economics. ; Human Geography. ; Management. ; Economics.
    Description / Table of Contents: Introduction: Management geography—An Asian perspective focusing on Japan and surrounding regions -- Performance analysis of boundary spanners in multinational enterprises through the lens of management geography -- Changes in the locational conditions of the Japanese machinery and instrument industry in China: A case study of the Dalian Economic and Technological Development Zone -- Management issues in global R&D of Japanese chemical companies -- Small- and medium-sized “global-niche” firms in Japan: A key for the rejuvenation of Japan’s local economy? -- Industrial agglomeration and regional development planning analysis by GIS in the city of Utsunomiya, Tochigi, Japan -- Unique functions of a metropolitan co-working space: A case study in Tokyo, Japan -- How customer service centers in foreign cities serving Japan changed their business?: A case study of the city of Dalian, China -- Factors influencing enterprise development in the inland regions of Fujian province in China -- Transformation of agricultural management in Japan under globalization pressure: A focus on product differentiation strategy. .
    Abstract: Management geography explores the spatial characteristics of management-related issues, especially of firms. This book discusses management geography in Japan and other Asian countries from Asian perspectives. The field has made significant contributions to the global economy but has not been deeply investigated in English-language geographical literature to date. The book addresses the following critical questions: What kinds of challenges do multinational corporations in Japan and other Asian countries face? How are managerial actors in multinational enterprises (MNEs) embracing boundary-spanning activities in a global context? How do firms and related entities cultivate business pipelines and ‘buzz’ within and beyond local regions? How do actors in Japanese MNEs, small- and medium-sized enterprises (SMEs) and related institutions embed various managerial processes at overseas locations? This book consists of two parts: Part I discusses the application and roles of Japanese and international managerial practices in the globalizing world. Part II examines changing business communities in the industrial and rural spaces of East Asia, focusing primarily on Japan and China. This work will interest readers in a wide range of fields, including geography, management studies, economics, urban planning and sociology. The book is also suitable for upper-level undergraduate students and graduate students in geography, management studies and related fields.
    Type of Medium: Online Resource
    Pages: IX, 228 p. 39 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811944031
    Series Statement: International Perspectives in Geography, AJG Library, 19
    DDC: 304.2
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Sustainability. ; Geography. ; Environmental management. ; Sustainability. ; Regional Geography. ; Environmental Management.
    Description / Table of Contents: Chapter1. Global Mountain Awareness -- Chapter2. An International Mountain Involvement: The Beginnings -- Chapter3. Mountain Strategy in Munich, 1974: On Track to the Himalaya -- Chapter4. Darjeeling: Personal Awakening to High Mountains and Refugees -- Chapter5. Moscow and the Caucasus: The IGU in the Cold War -- Chapter6. United Nations University: Agency with a Mountain Mission -- Chapter7. Himalayan Reconnaissance 1978: Deforestation, Landslides, and Farmers -- Chapter8. The China Connection: Privileged Entry to a Closed Country -- Chapter9. Beyond Lhasa: Opening China to Collaborative Mountain Research -- Chapter10. Breakthrough: Environmental Degradation Theory Overturned -- Chapter11. China Revisited 1985: Yunnan and the Jade Dragon Snow Mountains -- Chapter12. The Mohonk Process: Mobilization of the Mountain Advocates -- Chapter13. Mountain Road to Rio: The UN Earth Summit 1992 -- Chapter14. Return to China 1991–1996: Mountain People of Yunnan and Mass Tourism -- Chapter15. Roof of the World: The Pamir, 1999: “A Catastrophe of Biblical Proportions” -- Chapter16. Threatened Disasters in the Pamir and Himalaya -- Chapter17. The Evolution of the Mountain Cause. .
    Abstract: This second edition of “Sustainable Mountain Development” is a history of the development of mountain environmental awareness from its origins during the Stockholm Conference on the Environment in 1973. This provided intellectual input into UNESCO’s MAB Programme, especially MAB-6 (Impact of Human Activities on Mountain Environments), The International Geographical Union’s commission on mountains, and The United Nations University’s (UNU) mountain project, the latter initiated in 1978. All this research and intellectual activity saw its maturation during the 1992 Earth Summit held in Rio de Janeiro. The major document universally agreed upon was AGENDA 21, with Chapter 13 concentrating on mountain environmental problems which led to 2002 being dedicated as The International Year of Mountains, and December 17th as International Mountain Day. The research that inspired this book, accompanied by intensive environmental and political activity, was initially propagated by a small group of colleagues that ultimately expanded to a world-wide endeavour. The work was recognised by three awards of the King Albert Gold Medal, two RGS Gold Medals, approved by Her Majesty Queen Elizabeth II, and countless other awards. It led to the founding of the International Mountain Society in 1980 and its quarterly journal “Mountain Research and Development” (1981). The work expanded into subsequent research efforts, including specific assessments of projected major catastrophes such as the status of the potential outbreak of glacier lakes (GLOFs), the impacts of climate warming, and incorporation of the mountain subsistence men and women whose environmental knowledge was enthusiastically recognized. This edition provides a new epilogue, which outlines the considerable changes to world environmental assessment since the establishment of 2002 as the International Year of Mountains, and notes that 2022 has been designated as the International Year of Sustainable Mountain Development.
    Type of Medium: Online Resource
    Pages: XVI, 301 p. 152 illus., 136 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030960292
    DDC: 304.2
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Pharmacovigilance. ; Pharmaceutical chemistry. ; Chemistry, Physical and theoretical. ; Biotechnology. ; Pharmacology. ; Drug Safety and Pharmacovigilance. ; Pharmaceutics. ; Theoretical Chemistry. ; Biotechnology.
    Description / Table of Contents: Introduction -- PART 1: How Drugs are Discovered and Developed in the Pharmaceutical Industry -- Introduction to Drugs and Drug Targets -- Background to chemistry of small and large molecules -- Laying the foundations- Drug discovery from antiquity to the twenty first century -- Part II-The drug development pipeline – discovery to testing in humans -- Drug discovery pipeline overview -- Target discovery -- Medicinal chemistry -- Biotherapeutics -- Screening for hits -- Process chemistry and formulation -- Preclinical development -- Part III-The drug development pipeline – clinical trials to marketing authorisation -- Clinical trials -- Regulatory affairs and marketing approval -- Diagnostics and personalized medicine -- Putting it All Together: a drug development case history -- Part IV- The Global Pharmaceuticals Business -- Commercial aspects of drug development -- Challenges and responses -- Part V - Professional Interactions with the Drug Discovery Industry.-Professional Interactions with the Drug Discovery Industry: Technology Transfer Executives -- Recruitment Executives -- Pharmaceutical translators and Interpreters.
    Abstract: The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators .
    Type of Medium: Online Resource
    Pages: XVII, 402 p. 102 illus., 20 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030578145
    DDC: 615
    Language: English
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  • 6
    Keywords: Sustainability. ; Tourism. ; Management. ; Sustainability. ; Tourism Management. ; Tourism Economics.
    Description / Table of Contents: Part 1 - Planning and Management of Sustainable Tourism -- 1. Cultural Heritage Management in Post-Industrial Sites: The Case Study of Seka Paper Museum and Kocaeli Science Center -- 2. The Sanctuary of Bom Jesus Do Monte (Braga) World Heritage and Sustainable Tourism -- 3. Wine tourism as an alternative of sustainable development of the rural region – a case study of the Czech Republic -- 4. Place attachment as a multidimensional construct: a structural equation modelling -- 5. A tool for assessing public space occupation as applied to a historical district: Alfama, Lisbon (Portugal) -- 6. “We Gave our Today for your Tomorrow”: Peace Education and Sustainable Tourism in the United Nations Memorial Cemetery in Korea -- Part 2: Sustainable Cultural Tourism Development in a Digital Era -- 7. Museums and Digital Mobile Technologies: Proposal Application for the Ducal Palace of the Bragança -- 8. Tourism, territory (ies) and local development practices of participation and governance of the destination Alto Minho (Portugal) -- 9. BRENDA Digital Tours: Designing a Gamified Augmented Reality Application to Encourage Gastronomy Tourism and local food exploration -- 10. The Application of Geospatial Information Technology in Heritage Tourism in Plateau State, Nigeria -- Part 3: Social and Economic Impacts of Cultural Tourism -- 11. Perspective of Mapungubwe Descendants Traditional Leaders concerning their traditional values and Cultural Heritage Preservation -- 12. Tourism Economics – Tourists’ Perception of the Tourist Tax in Oporto -- 13. Salzedas/S. João de Tarouca as a possible UNESCO cultural tourism nomination -- 14. An Approach for Documenting the Historic Drinking Water Troughs of Karachi Pakistan -- 15. The Impacts of the cancellation off Historic Re-enactments in Portugal - The Case of Santa Maria da Feira -- 16. Sustainability of Cultural Tourism in East African Community -- Part 4: Sustainable Tourism Development in Urban Areas -- 17. A study of characteristics of vernacular dwellings in Guanzhong Area: Taking Dangjia Village and Guanzhong Folk Museum as Examples -- 18. How do cultural vitality and socio - economic factors influence urban tourism? Evidence from Romanian cities -- 19. Health and Wellness Tourism: Contributions for a local sustainable development strategy -- 20. Alcobaça’s agro-landscape hinterland: new rurality and a sustainable approach to tourism -- 21. Self-sufficient city As Organising Principle for Sustainable Development: Making Bozcaada a Self-sufficient and Sustainable Island -- 22. Tourist demand for railway heritage: The case of the historic train in Douro, Portugal.
    Abstract: This book is an assemblage of diverse yet homogenous research papers that bring together the issues and challenges of cultural heritage conservation and tourism sustainability. The richness of this book stems from its inclusion of diverse case studies from around the globe while scrutinizing the cases of both deterioration and sustainability of cultural heritage belonging to different eras. This book sheds light on the connections between culture as an essential dimension of local sustainability and cultural dimensions of sustainable tourism, further contributing to the complex discussion between culture and tourism. This book gives an overview of current research and subjects of discussion that focuses on cultural sustainable tourism through several sections, such as planning and management of sustainable tourism, sustainable cultural tourism development in a digital era, social and economic impacts of cultural tourism, and sustainable tourism development in urban areas.
    Type of Medium: Online Resource
    Pages: XIV, 264 p. 113 illus., 97 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783031078194
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    DDC: 304.2
    Language: English
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