Publication Date:
2018-06-27
Description:
miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models 〈i〉miR-23b〈/i〉 and 〈i〉miR-218〈/i〉 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models, Published online: 26 June 2018; doi:10.1038/s41467-018-04892-4 Depletion of the splicing factors MBNL 1 and 2 causes myotonic dystrophy. Here, the authors show that miR-23b and miR-218 target MBNL proteins, and that antagonists to these miRNAs rescue mis-splicing events in myoblasts and boost MBNL expression and rescue pathology in mouse models.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
Permalink