ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

Unbekannt

Response to Comment on "U-Th dating of carbonate crusts reveals Neandertal origin of Iberian cave art" (2018)

Hoffmann, D. L., Standish, C. D., Garcia-Diez, M., Pettitt, P. B., Milton, J. A., Zilhao, J., Alcolea-Gonzalez, J. J., Cantalejo-Duarte, P., Collado, H., de Balbin, R., Lorblanchet, M., Ramos-Munoz, J., Weniger, G.- C., Pike, A. W. G.

American Association for the Advancement of Science (AAAS)

In: Science

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2018-10-12

Beschreibung: Slimak et al . challenge the reliability of our oldest (〉65,000 years) U-Th dates on carbonates associated with cave paintings in Spain. They cite a supposed lack of parietal art for the 25,000 years following this date, along with potential methodological issues relating to open-system behavior and corrections to detrital or source water 230 Th. We show that their criticisms are unfounded.

Schlagwort(e): Anthropology

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

Permalink

	Standort	Signatur	Erwartet	Verfügbarkeit

Andere fanden auch interessant ...

AKTUELLE ARTIKEL

S·F·X

Volltext

2

Unbekannt

Beyond the molecular movie: Dynamics of bands and bonds during a photoinduced phase transition (2018)

Nicholson, C. W., Lücke, A., Schmidt, W. G., Puppin, M., Rettig, L., Ernstorfer, R., Wolf, M.

American Association for the Advancement of Science (AAAS)

In: Science

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2018-11-16

Beschreibung: Ultrafast nonequilibrium dynamics offer a route to study the microscopic interactions that govern macroscopic behavior. In particular, photoinduced phase transitions (PIPTs) in solids provide a test case for how forces, and the resulting atomic motion along a reaction coordinate, originate from a nonequilibrium population of excited electronic states. Using femtosecond photoemission, we obtain access to the transient electronic structure during an ultrafast PIPT in a model system: indium nanowires on a silicon(111) surface. We uncover a detailed reaction pathway, allowing a direct comparison with the dynamics predicted by ab initio simulations. This further reveals the crucial role played by localized photoholes in shaping the potential energy landscape and enables a combined momentum- and real-space description of PIPTs, including the ultrafast formation of chemical bonds.

Schlagwort(e): Physics

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

Permalink

	Standort	Signatur	Erwartet	Verfügbarkeit

Andere fanden auch interessant ...

AKTUELLE ARTIKEL

S·F·X

Volltext

3

Unbekannt

Recruiting more proteins to the RNA world (2018)

Scott, W. G., Nagai, K.

American Association for the Advancement of Science (AAAS)

In: Science

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2018-11-09

Schlagwort(e): Biochemistry

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

Permalink

	Standort	Signatur	Erwartet	Verfügbarkeit

Andere fanden auch interessant ...

AKTUELLE ARTIKEL

S·F·X

Volltext

4

Unbekannt

VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma (2018)

Zhang, J., Wu, T., Simon, J., Takada, M., Saito, R., Fan, C., Liu, X.-D., Jonasch, E., Xie, L., Chen, X., Yao, X., Teh, B. T., Tan, P., Zheng, X., Li, M., Lawrence, C., Fan, J., Geng, J., Liu, X., Hu, L., Wang, J., Liao, C., Hong, K., Zurlo, G., Parker, J. S., Auman, J. T., Perou, C. M., Rathmell, W. K., Kim, W. Y., Kirschner, M. W., Kaelin, W. G., Baldwin, A. S., Zhang, Q.

American Association for the Advancement of Science (AAAS)

In: Science

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2018-07-20

Beschreibung: Inactivation of the von Hippel-Lindau (VHL) E3 ubiquitin ligase protein is a hallmark of clear cell renal cell carcinoma (ccRCC). Identifying how pathways affected by VHL loss contribute to ccRCC remains challenging. We used a genome-wide in vitro expression strategy to identify proteins that bind VHL when hydroxylated. Zinc fingers and homeoboxes 2 (ZHX2) was found as a VHL target, and its hydroxylation allowed VHL to regulate its protein stability. Tumor cells from ccRCC patients with VHL loss-of-function mutations usually had increased abundance and nuclear localization of ZHX2. Functionally, depletion of ZHX2 inhibited VHL-deficient ccRCC cell growth in vitro and in vivo. Mechanistically, integrated chromatin immunoprecipitation sequencing and microarray analysis showed that ZHX2 promoted nuclear factor B activation. These studies reveal ZHX2 as a potential therapeutic target for ccRCC.

Schlagwort(e): Cell Biology, Medicine, Diseases

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

Permalink

	Standort	Signatur	Erwartet	Verfügbarkeit

Andere fanden auch interessant ...

AKTUELLE ARTIKEL

S·F·X

Volltext

5

Unbekannt

Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma (2018)

Miao, D., Margolis, C. A., Gao, W., Voss, M. H., Li, W., Martini, D. J., Norton, C., Bosse, D., Wankowicz, S. M., Cullen, D., Horak, C., Wind-Rotolo, M., Tracy, A., Giannakis, M., Hodi, F. S., Drake, C. G., Ball, M. W., Allaf, M. E., Snyder, A., Hellmann, M. D., Ho, T., Motzer, R. J., Signoretti, S., Kaelin, W. G., Choueiri, T. K., Van Allen, E. M.

American Association for the Advancement of Science (AAAS)

In: Science

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2018-02-16

Beschreibung: Immune checkpoint inhibitors targeting the programmed cell death 1 receptor (PD-1) improve survival in a subset of patients with clear cell renal cell carcinoma (ccRCC). To identify genomic alterations in ccRCC that correlate with response to anti–PD-1 monotherapy, we performed whole-exome sequencing of metastatic ccRCC from 35 patients. We found that clinical benefit was associated with loss-of-function mutations in the PBRM1 gene ( P = 0.012), which encodes a subunit of the PBAF switch-sucrose nonfermentable (SWI/SNF) chromatin remodeling complex. We confirmed this finding in an independent validation cohort of 63 ccRCC patients treated with PD-1 or PD-L1 (PD-1 ligand) blockade therapy alone or in combination with anti–CTLA-4 (cytotoxic T lymphocyte-associated protein 4) therapies ( P = 0.0071). Gene-expression analysis of PBAF-deficient ccRCC cell lines and PBRM1 -deficient tumors revealed altered transcriptional output in JAK-STAT (Janus kinase–signal transducers and activators of transcription), hypoxia, and immune signaling pathways. PBRM1 loss in ccRCC may alter global tumor-cell expression profiles to influence responsiveness to immune checkpoint therapy.

Schlagwort(e): Medicine, Diseases

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

Permalink

	Standort	Signatur	Erwartet	Verfügbarkeit

Andere fanden auch interessant ...

AKTUELLE ARTIKEL

S·F·X

Volltext

6

Unbekannt

U-Th dating of carbonate crusts reveals Neandertal origin of Iberian cave art (2018)

Hoffmann, D. L., Standish, C. D., Garcia-Diez, M., Pettitt, P. B., Milton, J. A., Zilhao, J., Alcolea-Gonzalez, J. J., Cantalejo-Duarte, P., Collado, H., de Balbin, R., Lorblanchet, M., Ramos-Munoz, J., Weniger, G.- C., Pike, A. W. G.

American Association for the Advancement of Science (AAAS)

In: Science

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2018-02-23

Beschreibung: The extent and nature of symbolic behavior among Neandertals are obscure. Although evidence for Neandertal body ornamentation has been proposed, all cave painting has been attributed to modern humans. Here we present dating results for three sites in Spain that show that cave art emerged in Iberia substantially earlier than previously thought. Uranium-thorium (U-Th) dates on carbonate crusts overlying paintings provide minimum ages for a red linear motif in La Pasiega (Cantabria), a hand stencil in Maltravieso (Extremadura), and red-painted speleothems in Ardales (Andalucía). Collectively, these results show that cave art in Iberia is older than 64.8 thousand years (ka). This cave art is the earliest dated so far and predates, by at least 20 ka, the arrival of modern humans in Europe, which implies Neandertal authorship.

Schlagwort(e): Anthropology

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

Permalink

	Standort	Signatur	Erwartet	Verfügbarkeit

Andere fanden auch interessant ...

AKTUELLE ARTIKEL

S·F·X

Volltext

7

Unbekannt

Nigeria's new GDP means scientists suffer (2018)

Balogun, W. G., Seeni, A.

American Association for the Advancement of Science (AAAS)

In: Science

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2018-03-09

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

Permalink

	Standort	Signatur	Erwartet	Verfügbarkeit

Andere fanden auch interessant ...

AKTUELLE ARTIKEL

S·F·X

Volltext

8

Unbekannt

An on/off Berry phase switch in circular graphene resonators (2017)

Ghahari, F., Walkup, D., Gutierrez, C., Rodriguez-Nieva, J. F., Zhao, Y., Wyrick, J., Natterer, F. D., Cullen, W. G., Watanabe, K., Taniguchi, T., Levitov, L. S., Zhitenev, N. B., Stroscio, J. A.

American Association for the Advancement of Science (AAAS)

In: Science

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2017-05-26

Beschreibung: The phase of a quantum state may not return to its original value after the system’s parameters cycle around a closed path; instead, the wave function may acquire a measurable phase difference called the Berry phase. Berry phases typically have been accessed through interference experiments. Here, we demonstrate an unusual Berry phase–induced spectroscopic feature: a sudden and large increase in the energy of angular-momentum states in circular graphene p-n junction resonators when a relatively small critical magnetic field is reached. This behavior results from turning on a Berry phase associated with the topological properties of Dirac fermions in graphene. The Berry phase can be switched on and off with small magnetic field changes on the order of 10 millitesla, potentially enabling a variety of optoelectronic graphene device applications.

Schlagwort(e): Physics, Applied

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

Permalink

	Standort	Signatur	Erwartet	Verfügbarkeit

Andere fanden auch interessant ...

AKTUELLE ARTIKEL

S·F·X

Volltext

9

Unbekannt

Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining (2018)

Pryor, J. M., Conlin, M. P., Carvajal-Garcia, J., Luedeman, M. E., Luthman, A. J., Small, G. W., Ramsden, D. A.

American Association for the Advancement of Science (AAAS)

In: Science

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2018-09-14

Beschreibung: The nonhomologous end–joining (NHEJ) pathway preserves genome stability by ligating the ends of broken chromosomes together. It employs end-processing enzymes, including polymerases, to prepare ends for ligation. We show that two such polymerases incorporate primarily ribonucleotides during NHEJ—an exception to the central dogma of molecular biology—both during repair of chromosome breaks made by Cas9 and during V(D)J recombination. Moreover, additions of ribonucleotides but not deoxynucleotides effectively promote ligation. Repair kinetics suggest that ribonucleotide-dependent first-strand ligation is followed by complementary strand repair with deoxynucleotides, then by replacement of ribonucleotides embedded in the first strand with deoxynucleotides. Our results indicate that as much as 65% of cellular NHEJ products have transiently embedded ribonucleotides, which promote flexibility in repair at the cost of more fragile intermediates.

Schlagwort(e): Biochemistry, Molecular Biology

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

Permalink

	Standort	Signatur	Erwartet	Verfügbarkeit

Andere fanden auch interessant ...

AKTUELLE ARTIKEL

S·F·X

Volltext

10

Unbekannt

Response to Comment on "The earliest modern humans outside Africa" (2018)

Hershkovitz, I., Duval, M., Grün, R., Mercier, N., Valladas, H., Ayalon, A., Bar-Matthews, M., Weber, G. W., Quam, R., Zaidner, Y., Weinstein-Evron, M.

American Association for the Advancement of Science (AAAS)

In: Science

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2018-10-26

Beschreibung: Our original claim, based on three independent numerical dating methods, of an age of ~185,000 years for the Misliya-1 modern human hemi-maxilla from Mount Carmel, Israel, is little affected by discounting uranium-series dating of adhering crusts. It confirms a much earlier out-of-Africa Homo sapiens expansion than previously suggested by the considerably younger (90,000 to 120,000 years) Skhul/Qafzeh hominins.

Schlagwort(e): Anthropology

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Geologie und Paläontologie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

Permalink

	Standort	Signatur	Erwartet	Verfügbarkeit

Andere fanden auch interessant ...

AKTUELLE ARTIKEL

S·F·X

Volltext