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PNAS - Proceedings of the National Academy of Sciences (1)
Journal of Petroleum Technology. 2015; 67(10): 92-92. Published 2015 Oct 01. doi: 10.2118/1015-0092-jpt. (1)
Journal of Petroleum Technology. 2016; 68(10): 73-73. Published 2016 Oct 01. doi: 10.2118/1016-0073-jpt. (1)
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PNAS - Proceedings of the National Academy of Sciences (1)
Journal of Petroleum Technology. 2015; 67(10): 92-92. Published 2015 Oct 01. doi: 10.2118/1015-0092-jpt. (1)
Journal of Petroleum Technology. 2016; 68(10): 73-73. Published 2016 Oct 01. doi: 10.2118/1016-0073-jpt. (1)
113
11495

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Assembly of the huntingtin exon1 fibril core [Biochemistry] (2016)

Hoop, C. L., Lin, H.-K., Kar, K., Magyarfalvi, G., Lamley, J. M., Boatz, J. C., Mandal, A., Lewandowski, J. R., Wetzel, R., van der Wel, P. C. A.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Details

Publikationsdatum: 2016-02-10

Beschreibung: Polyglutamine expansion within the exon1 of huntingtin leads to protein misfolding, aggregation, and cytotoxicity in Huntington’s disease. This incurable neurodegenerative disease is the most prevalent member of a family of CAG repeat expansion disorders. Although mature exon1 fibrils are viable candidates for the toxic species, their molecular structure and how...

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft