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  • Articles  (10)
  • Articles: DFG German National Licenses  (10)
  • Immunohistochemistry  (10)
  • 1
    Electronic Resource
    Electronic Resource
    Somatostatinergic nerves in the cervical spinal cord of the monkey (1979)
    Springer
    Cell & tissue research 200 (1979), S. 83-90 
    Details
    ISSN: 1432-0878
    Keywords: Spinal cord ; Tupaia ; Somatostatin ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Somatostatinergic nerves in the spinal cord of the monkey were investigated utilizing immunohistochemistry with various antibodies against synthetic somatostatin. In contrast to earlier investigations, it is shown that somatostatinergic nerve endings occur in most of the areas of the grey matter of the spinal cord. The somatostatinergic axons are, however, characteristically distributed in three main regions: (1) Densely-packed endings are seen in lamina II of the substantia gelatinosa, forming a crescent-shaped pattern in the columna dorsalis. Somatostatin immunoreactivity is also seen in lamina I and in the Lissauer tract. (2) A fine network of fibers is observed around the central canal; the endings are concentrated on special cell bodies. Some single perikarya are also stained in this region. (3) A loose network of single fibers is found ending on perikarya of the columna lateralis or ventralis. The perikarya of the nerve axons, with the exception of those terminating in the columna dorsalis, have as yet not been identified. In order to better understand the somatostatinergic system of the spinal cord, these newly-detected somatostatinergic nerves must be studied and their exact pathways analyzed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236889
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Insulin-, glucagon-, and somatostatin-immunoreactive endocrine cells in the equine pancreas (1976)
    Springer
    Cell & tissue research 172 (1976), S. 447-454 
    Details
    ISSN: 1432-0878
    Keywords: Pancreas ; Horse ; Immunohistochemistry ; Insulin ; Glucagon ; Somatostatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Equine pancreas was investigated with immunohistochemical methods to study the distribution of endocrine cells immunoreactive to antiinsulin, anti-glucagon, and anti-somatostatin. A-cells demonstrable by antiglucagon are located in the center of Langerhans islets and frequently in the duct epithelium. Few A-cells are seen associated to acini. Anti-insulin reactive B-cells form a large zone around the center of the Langerhans islets in which some B-cells lie between exocrine cells and others, although few, are located in the duct epithelium. D-cells stained with anti-somatostatin serum form a discontinuous outermost zone around the Langerhans islets. In some islets the D-cells are also observed among the B-cells or between the border of A- and B-cells. Single D-cells are seen in the duct epithelium or between acinar cells. In younger horses, endocrine cells are more frequently associated in bulges of the duct system. The histotopographic relation between these endocrine cell types is discussed with respect to its functional significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220331
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  • 3
    Electronic Resource
    Electronic Resource
    Met-enkephalin-like immunoreactivity in Merkel cells (1979)
    Springer
    Cell & tissue research 201 (1979), S. 343-348 
    Details
    ISSN: 1432-0878
    Keywords: Merkel cell ; Sinus hair follicle ; Rat skin ; Enkephalin ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The Merkel cells from sinus hair follicles of rats were investigated by immunohistochemistry using different antisera against neuropeptides and gastroenteropancreatic (GEP)-hormones. For the first time it has been demonstrated that Merkel cells exhibit an immunoreactivity towards metenkephalin (methionine-enkephalin). The met-enkephalin immunoreactivity was restricted to Merkel cells and was not found in associated nerve axons or terminals. Denervation of Merkel cells did not affect the met-enkephalin immunoreactivity. Antisera against leu-enkephalin (leucine-enkephalin) and other polypeptides did not produce an immunoreaction. The demonstration of met-enkephalin-like immunoreactivity supports the concept that the Merkel cell is a member of the paraneuronal system and a potential neuroreceptor cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236994
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  • 4
    Electronic Resource
    Electronic Resource
    Substance P-immunoreactive neurons in the brainstem of the cat related to cardiovascular centers (1985)
    Springer
    Cell & tissue research 241 (1985), S. 31-41 
    Details
    ISSN: 1432-0878
    Keywords: Substance P ; Cardiovascular system ; Central nervous system ; Immunohistochemistry ; Mapping ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution of substance P-immunoreactivity (SP-IR) in the brainstem and spinal cord of normal and colchicine-pretreated cats was analysed using the peroxidase-antiperoxidase (PAP) technique. Numerous SP-IR fibers are present in the nucleus solitarius, nucleus dorsalis nervi vagi and nucleus spinalis nervi trigemini, various parts of the formatio reticularis, substantia grisea centralis mesencephali, locus coeruleus and nucleus parabrachialis. SP-IR perikarya occur in the substantiae gelatinosa and intermedia of the spinal cord, the nucleus spinalis nervi trigemini-pars caudalis, the nucleus dorsalis nervi vagi, and the nucleus solitarius, as well as in the adjacent formatio reticularis and the medullary nuclei of the raphe. In addition, SP-IR cell bodies are located in the nuclei raphe magnus and incertus, ventral and dorsal to the nucleus tegmentalis dorsalis (Gudden), nucleus raphe dorsalis, substantia grisea centralis mensencephali, locus coeruleus, nucleus parabrachialis and colliculus superior. The results indicate that SP-IR neurons may be involved in the regulation of cardiovascular functions both at the central and peripheral level. A peripheral afferent portion seems to terminate in the nucleus solitarius and an efferent part is postulated to originate from the nucleus dorsalis nervi vagi and from the area of the nuclei retroambiguus, ambiguus and retrofacialis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214623
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  • 5
    Electronic Resource
    Electronic Resource
    The auricular myocardiocytes of the heart constitute an endocrine organ characterization of a porcine cardiac peptide hormone, cardiodilatin-126 (1984)
    Springer
    Cell & tissue research 238 (1984), S. 425-430 
    Details
    ISSN: 1432-0878
    Keywords: Heart, atrium ; Myoendocrine cells ; Cardiodilatin ; Peptide hormone ; Immunohistochemistry ; Pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A peptide hormone was extracted from the porcine right atrium following a bioassay for differential vaso-relaxant effects on smooth muscle strips from aorta and renal and inferior mesenteric arteries. The isolation procedure included several steps of gel-permeation and ion-exchange chromatography, and high performance liquid chromatography. During the isolation procedure, other peptides of smaller molecular weight were also found, which, in relation to cardiodilatin-126 (CDD-126), are shorter at their N-terminal. Among these, CDD-88 has also been isolated and characterizied, and has been established as a prominent member of the cardiac hormone family. The N-terminal and C-terminal segments of the 126 amino acid-containing molecule were synthesized and used to raise region-specific antibodies. The natural peptide was then localized within myoendocrine cells of the right atrium where specific atrial granules are located. Renal effects of cardiodilation were studied in conscious dogs and showed strong diuretic and natriuretic activities. According to our functional studies, cardiodilatin-126 and cardiodilatin-88 possess qualities of a significant hormone family regarding the regulation of extracellular fluid volume and blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219856
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  • 6
    Electronic Resource
    Electronic Resource
    Ultrastructural identification of a new cell type — the N-cell as the source of neurotensin in the gut mucosa (1977)
    Springer
    Cell & tissue research 184 (1977), S. 445-452 
    Details
    ISSN: 1432-0878
    Keywords: Tupaia belangeri (Primate) ; Small intestine ; Neurotensin ; Immunohistochemistry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The neurotensin-cell is identified immunohistochemically and ultrastructurally by differential counting of endocrine cells in the gut of a primate (Tupaia belangen). Utilizing light microscopy, the EC-cells are identified by the Masson-Fontana silver stain; with the same method the neurotensin cells are not stained. The other endocrine cells have been quantified in the small intestine using the peroxidase-antiperoxidase stain with antisera against glucagon, somatostatin, cholecystokinin, gastrin, secretin, pancreatic polypeptide, gastric inhibitory peptide and neurotensin. In the ileal mucosa of Tupaia, the most frequent endocrine cell is the EC-cell followed by the glucagonoid cell, (L-cell). The immunoreactive neurotensin cell represents the third most frequent endocrine cell in this region. On the ultrastructural level, this third most frequent endocrine cell is a heretofore undescribed cell, the N-cell, containing electron dense secretory granules measuring 335±87 nm in diameter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220968
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  • 7
    Electronic Resource
    Electronic Resource
    Glucagon and glicentin immunoreactive cells in human colon (1982)
    Springer
    Cell & tissue research 221 (1982), S. 483-491 
    Details
    ISSN: 1432-0878
    Keywords: Glucagon ; Glicentin ; Human ; Colon ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An immunohistochemical study of glucagon and glicentin immunoreactive endocrine cells in the human colon epithelium was performed. Serial sections and qualitative analysis show a cell population containing both immunoreactivities. However, there is another cell population exhibiting only an immunoreactivity with glicentin. The exact distribution of these immunoreactive endocrine cells within the colon crypt segments is also analysed. The significance of these findings concerning the synthesis of glucagon and glicentin and their function is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215697
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  • 8
    Electronic Resource
    Electronic Resource
    Immunohistochemical identification of gastrointestinal neurotensin cells in human embryos (1977)
    Springer
    Cell & tissue research 184 (1977), S. 315-320 
    Details
    ISSN: 1432-0878
    Keywords: GEP-system ; Small intestine ; Human embryo ; Neurotensin ; Development ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The endocrine gastro-entero-pancreatic (GEP) system of 10 human embryos was studied with special reference to neurotensin-immunoreactive cells. These cells are first present in the ileal and jejunal mucosa of 12 to 13 week old embryos. Thereafter the neurotensin-immunoreactive cells are found regularly in these segments of the gut with an increasing number towards the terminal ileum. At about the twentieth week of gestation, the neurotensin cells are detected also in the lower duodenum, i.e. the distribution pattern is more extensive in this age than in younger embryos or in adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219893
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  • 9
    Electronic Resource
    Electronic Resource
    The projections of 5-hydroxytryptamine-accumulating neurones in the myenteric plexus of the small intestine of the guinea-pig (1998)
    Springer
    Cell & tissue research 291 (1998), S. 375-384 
    Details
    ISSN: 1432-0878
    Keywords: Key words: 5-hydroxytryptamine ; Myenteric neurones ; Retrograde tracing ; Immunohistochemistry ; Chemical coding ; Morphology ; Guinea-pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Retrograde tracing, combined with immunohistochemistry, was used to study the projections of 5-hydroxytryptamine (5-HT)-accumulating neurones within the ileum of the guinea-pig, with confocal microscopy being used to characterise further their morphology. Two classes of neurones in the myenteric plexus, capable of taking up 5-HT or analogues, were distinguished. One class had Dogiel type I morphology with lamellar dendrites, was located on the edge or in the middle of ganglia and lacked immunoreactivity for somatostatin (SOM). The other class had smooth ovoid cell bodies with multiple filamentous dendrites and a single axon and represented a subset of the SOM-immunoreactive interneurones in the myenteric plexus. Varicosities immunoreactive for 5-HT alone, 5-HT/SOM or SOM alone were present in the myenteric ganglia. Both classes of 5-HT-accumulating neurones had long aboral projections within the myenteric plexus (up to 100 mm long) and to the submucous plexus and probably function as descending interneurones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410051007
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  • 10
    Electronic Resource
    Electronic Resource
    Localization of the pituitary lactotropes and thyrotropes within Ambystoma gracile by histochemical and immunochemical methods (1978)
    Springer
    Cell & tissue research 189 (1978), S. 53-66 
    Details
    ISSN: 1432-0878
    Keywords: Pituitary gland (Ambystoma) ; Neoteny ; Thyrotropes ; Lactotropes ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The prolactin-producing cells are the first hormone-producing cells of the pars distalis to be differentiated within Ambystoma gracile. They first appear when the larvae attain a length of approximately 3.0 cm snout to vent length (SVL). Thyrotropes are observed as the next chromophilic cells to appear, and they occur when the larvae are approximately 4.5 cm SVL. Both thyrotropes and lactotropes increase in numbers until metamorphosis. Gonadotropes begin to appear when larvae attain a size of 5.0 cm SVL and become extremely abundant when larvae are in excess of 7.0 cm SVL. Animals, generally, exhibit the greatest number of thyrotropes just prior to the mean size for metamorphosis, and metamorphosing animals exhibit a dramatic reduction in the number of thyrotropes. Neotenous larvae have an abundant number of thyrotropes which are mainly located along the caudal periphery of the pituitary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223121
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