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  • Articles  (35)
  • Articles: DFG German National Licenses  (35)
  • Springer  (35)
  • Blackwell Science Ltd
  • National Academy of Sciences
  • 1980-1984  (35)
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  • Articles  (35)
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  • 1
    Electronic Resource
    Electronic Resource
    Interferon induction of (2′–5′) oligoisoadenylate synthetase in diploid and trisomy 21 human fibroblasts: Relation to dosage of the interferon receptor gene (IRFC) (1983)
    Springer
    Human genetics 〈Berlin〉 65 (1983), S. 108-111 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Trisomy 21 human fibroblasts are more sensitive to human interferon-α (IFN-α) than are diploid controls, consistent with the location of the gene (IFRC) which codes for the IFN-α receptor on chromosome 21. When compared in the antiviral assay, the difference in sensitivity is five-to tenfold, much greater then the 50% difference in IFRC gene dosage. An understanding of the mechanism by which this amplification of gene dosage occurs is relevant to the specific pathology of Down's syndrome and as a model system for studying the pathogenic effects of chromosomal aneuploidy. The enzyme (2′–5′) oligoisoadenylate synthetase (2–5A synthetase), which is believed to be central to the interferon-induced antiviral response, is induced 50% more in trisomy 21 fibroblasts than in diploid controls. Thus the amplification in response occurs subsequent to the binding of IFN-α to its receptor and the triggering of the first set of intracellular events, the latter exemplified by the induction of 2–5A synthetase. Similar results were obtained with IFN-γ, consistent with other evidence which indicates that a gene coding for a separate IFN-γ receptor is also located on chromosome 21.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286644
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  • 2
    Electronic Resource
    Electronic Resource
    Ouabain binding in rectal gland ofSqualus acanthias (1983)
    Springer
    The journal of membrane biology 75 (1983), S. 105-114 
    Details
    ISSN: 1432-1424
    Keywords: shark rectal gland ; ouabain binding ; (Na, K)-ATPase ; cyclic AMP ; slices ; isolated cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary In an attempt to examine the mechanisms of activation of (Na, K)-ATPase when epithelial transport is stimulated, the binding of ouabain to rectal gland tissue was measured before and after stimulation with dibutyryl cAMP and theophylline. Stimulation significantly altered the characteristics of ouabain binding to slices ofSqualus acanthias rectal gland and to isolated rectal gland cells, accelerating the rate of binding and increasing the amount of ouabain bound at equilibrium when low concentrations of ouabain (10−9 to 10−7 m) were present in the medium. Scatchard plots of ouabain binding were nonlinear, suggesting at least two classes of binding sites, one of higher and one of lower affinity. Stimulation with cAMP and theophylline appeared to increase the affinity of the high-affinity site. Ouabain binding was increased by cAMP and theophylline even in the presence of furosemide (10−4 m) or bumetanide (10−5 m), and when Li+ was substituted for Na+, or NO 3 − for Cl−-maneuvers known to inhibit rectal gland secretion. The changes in ouabain binding induced by cAMP and theophylline do not appear, therefore, to be secondary to secretory activity but may reflect a change in the configuration, environment or location of existing enzyme so as to enhance its activity. Stimulation of ouabain binding cannot be demonstrated in whole homogenates of rectal gland, indicating that intact cells are necessary for the cyclic AMP-induced increase in ouabain binding to become manifest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01995630
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  • 3
    Electronic Resource
    Electronic Resource
    Cyclic AMP stimulates ouabain-insensitive ion movement in shark rectal gland (1984)
    Springer
    Journal of comparative physiology 154 (1984), S. 139-144 
    Details
    ISSN: 1432-136X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary When the active sodium-potassium pump (Na−K-ATPase) of shark rectal glands is blocked by ouabain, the concentration of intracellular ions changes in the direction of equilibrium with extracellular fluid. These changes were examined when isolated perfused glands were in the basal state and also when they were stimulated to secrete with cAMP and theophylline, to see whether stimulation affected the passive movement of sodium, potassium and chloride across cell membranes. In basal glands 10−4M ouabain induced an increase of 30 meq/l in intracellular [Na+] and a decrease in intracellular [K+] of about 50 meq/l after 30 min, while intracellular [Cl−] was unchanged. In stimulated glands, these movements were exaggerated. The increase in intracellular [Na+] averaged 112 meq/l, and the decrease in intracellular [K+], 96 meq/l (P〈0.01), while mean intracellular [Cl−] rose by 80 meq/l. Furosemide, 10−4M, partially reversed the accelerated changes in intracellular electrolytes seen after ouabain was added to stimulated glands. These results are consistent with an action of cAMP upon a ouabaininsensitive cotransport of sodium, potassium and chloride in the rectal gland, analogous to that described in avian erythrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684137
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  • 4
    Electronic Resource
    Electronic Resource
    Automatic rezeroing of drifting physiologic signals (1980)
    Springer
    Medical & biological engineering & computing 18 (1980), S. 746-748 
    Details
    ISSN: 1741-0444
    Keywords: Autozeroing ; Barometric method ; Electronic circuit ; Instrumentation ; Plethysmography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract An electronic circuit is described which automatically rezeroes a physiologic signal whenever it reaches the limit of a display. This modified signal can be used for polygraph monitoring while the raw signal is processed by a wide-range high-resolution a.d. convertor. The device is currently used in conjunction with the barometric method for measuring tidal volume, but should find general use in plethysmography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02441900
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  • 5
    Electronic Resource
    Electronic Resource
    Optical second-harmonic generation in atomic calcium vapour (1981)
    Springer
    Optical and quantum electronics 13 (1981), S. 436-438 
    Details
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00620280
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  • 6
    Electronic Resource
    Electronic Resource
    Evidence for abnormal regulation of circulating 1α,25-dihydroxyvitamin D in patients with pulmonary tuberculosis and normal calcium metabolism (1984)
    Springer
    Calcified tissue international 36 (1984), S. 541-544 
    Details
    ISSN: 1432-0827
    Keywords: 1α25(OH)2D ; Hypercalcemia ; Normocalcemia ; Pulmonary tuberculosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Available evidence indicates that hypercalcemia in pulmonary tuberculosis results from increases in circulating 1α,25-dihydroxyvitamin D [1α,25(OH)2D]. To further characterize vitamin D metabolism in this disorder, the effects of vitamin D, 100,000 units a day for 4 days, were compared in 25 normal subjects and 11 patients with active pulmonary tuberculosis who were normocalcemic and had not had hypercalcemia. Serum calcium, phosphorus, 25-hydroxyvitamin D (25-OHD) and 1α,25(OH)2D were measured. Whereas vitamin D increased mean serum 25-OHD from 20±2 (±SE) to 40±5 ng/ml (P〈0.001) and did not change mean serum 1α,25(OH)2D in the normals (33±2 vs. 31±2 pg/ml), it increased mean serum 25-OHD from 21±4 to 55±13 ng/ml (P〈0.05) and mean serum 1α,25(OH)2D from 28±2 to 35±3 pg/ml (P〈0.05) in the patients. Serum calcium was normal and remained within the normal range in all subjects and patients. The findings indicate that there is a modest but significant abnormality in the regulation of circulating 1α,25(OH)2D in normocalcemic patients with pulmonary tuberculosis. The results are similar to those previously reported by us in normocalcemic patients with sarcoidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405362
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  • 7
    Electronic Resource
    Electronic Resource
    Lack of influence of isoproterenol, propranolol, and dopamine on immunoreactive parathyroid hormone and calcitonin in normal man (1983)
    Springer
    Calcified tissue international 35 (1983), S. 32-36 
    Details
    ISSN: 1432-0827
    Keywords: Isoproterenol ; Dopamine ; Propranolol ; PTH ; Calcitonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Available evidencein vitro andin vivo suggests that pharmacologic doses of isoproterenol stimulate the secretion of parathyroid hormone (PTH) and calcitonin (CT) and propranolol inhibits secretion. However, the findings in man are either quite modest or inconsistent. In view of this controversy, we examined the effects of isoproterenol, 0.15 µg intradermally (i.d.), dopamine, 5 µg/kg body weight over 60 min intravenously (i.v.), and propranolol, 1 mg over 5 min followed by 60 µg per min for 2 i.v. in normal human subjects. It was found that these agents did not alter serum calcium, serum immunoreactive PTH, or plasma immunoreactive CT. The findings do not support a physiologic role for biogenic amines in the control and regulation of PTH or CT secretion in normal man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405003
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  • 8
    Electronic Resource
    Electronic Resource
    Core points in double Heyting algebras and dissectable lattices (1983)
    Springer
    Algebra universalis 16 (1983), S. 204-218 
    Details
    ISSN: 1420-8911
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01191769
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  • 9
    Electronic Resource
    Electronic Resource
    Mutant HLA-A2 antigens as restricting elements for virus-specific cytotoxic T cells (1984)
    Springer
    Immunogenetics 19 (1984), S. 475-486 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mutants of the EB virus-transformed cell line T5-1 (HLA-Al, 2; B8, 27), bearing well-characterized alterations in HLA-A2 antigen expression and unable to bind the HLA-A2-specific monoclonal antibody 13137.2, have been tested for their susceptibility to EB virus-specific cytolysis using effector T-cell preparations functionally restricted through relevant HLA antigens. Initial experiments first confirmed that the parent line T5-1 was susceptible to cytolysis by both “common” A2-restricted and 1327-restricted effector cells. While those T5-1 mutants with little or no surface A2 expression were not lysed by A2-restricted effectors, those targets with quantitatively normal expression of mutant A2 molecules were as susceptible to A2-restricted lysis as the parent line itself. In contrast, all the T5-1 mutant lines were susceptible to B27-restricted cytolysis. The results demonstrate that experimentally induced mutations of HLA-A2 antigen structure, affecting a serologically defined site on the molecule, can occur without altering that same molecule's expression of the T cell-restricting determinant(s). Such experimentally induced mutations are quite different from the naturally occurring “variant” A2 antigens which are present within the serologically defined A2 antigen group and which show changes at the T cell-restricting site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403438
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  • 10
    Electronic Resource
    Electronic Resource
    Fixed points of Feigenbaum's type for the equationf p (λx)≡λf(x) (1984)
    Springer
    Communications in mathematical physics 93 (1984), S. 495-516 
    Details
    ISSN: 1432-0916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract Existence and hyperbolicity of fixed points for the mapN p :f(x) →λ−1 f p (λx), withf p p-fold iteration and λ=f p (0) are given forp large. These fixed points come close to being quadratic functions, and our proof consists in controlling perturbation theory about quadratic functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01212292
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