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  • Articles  (35)
  • Articles: DFG German National Licenses  (35)
  • 1990-1994  (35)
  • Medicine  (31)
  • Process Engineering, Biotechnology, Nutrition Technology  (4)
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  • Articles  (35)
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  • 1
    Electronic Resource
    Electronic Resource
    Organotin residue determination in poultry and turkey sample survey in the United States (1991)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 39 (1991), S. 917-921 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00005a023
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  • 2
    Electronic Resource
    Electronic Resource
    ANALYSIS OF Ly5 CHROMOSOME 1 POSITION USING ALLELIC DIFFERENCES AND RECOMBINANT INBRED MICE (1991)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 18 (1991), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Differences between the mouse Ly5a and Ly5b alleles can be distinguished on the basis of polymerase chain reaction (PCR)-restriction enzyme analysis and differential monoclonal antibody reactivities. To more precisely map the Ly5 gene on the mouse chromosome 1, analytical DNA and protein tests were performed on recombinant inbred strains of mice prepared from SJL/J (Ly5a) and B ALB/cke (Ly5b) progenitor strains. Each recombinant inbred strain was characterized to determine whether it carried the Ly5a or Ly5b allele. Both assays, DNA-PCR and protein-immunofluorescence, yielded identical results for each strain examined. Placement of the Ly5 gene with respect to other characterized markers of mouse chromosome 1 for these recombinant inbred mouse strains shows a gene order of Idh-1.Ity:Pep3:/Ly5, CfhJ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1991.tb00015.x
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  • 3
    Electronic Resource
    Electronic Resource
    BACTERIAL ADHERENCE AND VIABILITY ON CUTTING BOARD SURFACES (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food safety 14 (1994), S. 0 
    Details
    ISSN: 1745-4565
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The adherence and viability of Escherichia coli inoculated onto the surfaces of plastic cutting boards and new and used wood cutting boards were evaluated. Most of the inoculum was recovered from all surfaces after resident drying times of 5 min and from plastic surfaces at 24 h. When the exposure time was extended to 2 h, 〉 90% of the cells placed on new and used dry wood surfaces were not recovered after vigorous rinsing. Scanning electron microscopy showed that the bacteria resided within the structural xylem fibers and vegetative elements of the wood. After resident drying times of up to 2 h, almost 75% of the adherent bacteria on the wood surfaces were viable, as defined by a nalidixic acid direct viable count procedure. Microcosm studies showed no intrinsic growth-supporting or toxic properties of the cutting board materials. Bacteria that adhered to plastic surfaces were more easily removed by low-temperature washing than were cells that adhered to wood surfaces. These studies demonstrated that bacteria adhering to wood surfaces resided within the structural and vegetative elements of the wood's xylem tissues and were viable; wood was more retentive than plastic; penetration of the inoculum liquid promoted cell adherence to the wood matrix; and conditioning of wood with water before inoculation interfered with bacterial adherence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-4565.1994.tb00591.x
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  • 4
    Electronic Resource
    Electronic Resource
    Molecular Biology of Human Muscle Disease (1991)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 9 (1991), S. 41-46 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The molecular revolution that is transforming the entire biomedical field has had far-reaching impact in its application to inherited human muscle disease. The gene for Duchenne muscular dystrophy was one of the first cloned without knowledge of the defective protein product. This success was based ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0191-41
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  • 5
    Electronic Resource
    Electronic Resource
    Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the γ2 subunit of nicein/kalinin (LAMININ–5) (1994)
    [s.l.] : Nature Publishing Group
    Nature genetics 6 (1994), S. 299-304 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We have linked Herlitz's junctional epidermolysis bullosa (H–JEB) to the gene (LAMC2) encoding the γ2 subunit of nicein/kalinin, an isolaminin (laminin–5) expressed by basal keratinocytes. In four H–JEB kindreds, a maximum two–point lod score of 5.33 at θ=0 was ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0394-299
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  • 6
    Electronic Resource
    Electronic Resource
    EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts (1993)
    [s.l.] : Nature Publishing Group
    Nature genetics 4 (1993), S. 341-345 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The genes involved in the t(12;22)(q13;q12) translocation found recurrently in malignant melanoma of soft parts have been characterized and shown to form, in four cases studied, hybrid transcripts. The deduced chimaeric protein encoded by the der(22) chromosome consists of the N–terminal ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0893-341
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  • 7
    Electronic Resource
    Electronic Resource
    The effect of a new vitamin D analog, 22-oxa-1α,25(OH)2D3, on bone mineral metabolism in normal male rats (1992)
    Springer
    Calcified tissue international 50 (1992), S. 521-523 
    Details
    ISSN: 1432-0827
    Keywords: 22-oxa-1α, 25 Dihydroxyvitamin D3 ; 1,25(OH)2D3 ; Bone histomorphometry ; Bone Gla protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Thein vivo effects of 22-oxa-1α, 25 dihydroxyvitamin D3 (OCT), on bone mineral metabolism were investigated in normal male Sprague-Dawley rats. The rats were administered either vehicle (control), low-dose OCT (25 ng/100 g body weight), or high-dose OCT (250 ng/100 g body wt). High-dose OCT increased serum ionized calcium (P〈0.05) and decreased serum parathyroid hormone (PTH) (P〈0.05) at all time points and increased serum bone Gla protein on days 7 and 28 (P〈0.05) compared with controls. Lowdose OCT decreased serum PTH at all the time points (P〈0.05) compared with controls. Tibial bone histomorphometry showed no significant differences between the two doses of OCT and controls. We found that OCT has minimal direct effects on bone metabolism in normal male rats in contrast to 1,25 dihydroxyvitamin D3. This property may be advantageous in the treatment with OCT of cell-proliferative diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582166
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  • 8
    Electronic Resource
    Electronic Resource
    Lack of change of cancellous bone volume with short-term use of the new immunosuppressant rapamycin in rats (1993)
    Springer
    Calcified tissue international 53 (1993), S. 45-52 
    Details
    ISSN: 1432-0827
    Keywords: Rapamycin ; Bone mineral metabolism ; Bone Gla protein ; Immunosuppressants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Immunosuppressants have adverse effects on bone mineral metabolism in animal and human studies, with corticosteroids producing low-turnover osteopenia, and cyclosporin-A (CsA) producing high-turnover osteopenia. Rapamycin (RAPA) is a new immunosuppressant reported to be at least 10 times more potent than CsA, and acts via a different pathway to CsA and the other new immunosuppressant FK506. This study investigated the effects of RAPA on bone mineral metabolism in the rat. Forty-two, 10-week-old, male Sprague Dawley rats were divided into three groups, and treated according to the following protocol: group A (control) received RAPA vehicle by daily gavage for 14 days (n = 12); group B (high dose RAPA) received RAPA 2.5 mg/kg/day by daily gavage for 14 days (n = 15); group C (low dose RAPA) received RAPA 1.25 mg/kg/day by daily gavage for 14 days (n = 15). Rats were weighed and bled on days 0, 7, and 14 for measurement of blood ionized calcium, bone Gla protein (BGP), parathyroid hormone (PTH), and 1,25(OH)2D. Tibial bone histomorphometry was determined on day 14 after double-calcein labeling. Weight gain was similar in the two groups treated with RAPA compared with control animals. High-dose RAPA (group B) transiently depressed serum BGP levels on day 7, with elevated blood ionized calcium levels on day 7, and lowered 1,25(OH)2D levels on day 14. Serum PTH levels were unchanged. Low dose RAPA (group C) did not affect calciotropic hormones. Histomorphometric analyses of tibial metaphyses revealed that parameters of bone formation and resorption were not significantly different in the groups treated with RAPA (group B and C) compared with control animals (group A). Trabecular bone volume (BV/TV) in group B (high-dose RAPA) (15.39 ± 1.01%) and C (low-dose RAPA) (15.38 ±0.57%) was not significantly altered compared with group A (control) (16.42 ± 0.86%). Short-term treatment with RAPA, unlike CsA, does not result in excess resorption and loss of bone volume. The depressed serum 1,25(OH)2D levels seen with high-dose RAPA therapy may adversely effect bone mineral metabolism in the long term.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01352014
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  • 9
    Electronic Resource
    Electronic Resource
    Ability of vertebral dimensions from a single radiograph to identify fractures (1992)
    Springer
    Calcified tissue international 51 (1992), S. 95-99 
    Details
    ISSN: 1432-0827
    Keywords: Epidemiology ; Vertebral fractures ; Morphology ; Prospective studies ; Fracture prevalence, incidence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary It has been proposed that vertebral dimensions be used to objectively identify vertebral fractures, permitting standardization of methodology for comparisons between studies. In this report, we evaluate the ability of various vertebral dimensions and ratios to identify “abnormal” vertebrae. As no “gold standard” exists for prevalent vertebral fractures, we examined the ability of cross-sectional dimensions (at a single point in time) to detect fractured vertebrae that had been identified from changes in dimensions compared with previous radiographs. Theoretically, a cutoff of 3 SD below the mean will rarely misclassify normal vertebrae as fractured (specificity=99.9%). However, we found that this cutoff correctly identified only about 70% of the incident fractures. A less stringent criterion (2 SD below the mean; theoretical specificity=97.7%) identified about 85–90% of true fractures. Dividing by stature or other vertebral heights sometimes yielded marginal improvements in the ability of the anterior or posterior height dimensions to diagnose fractures. The results suggest that the true fracture prevalence may sometimes be substantially higher than suggested by cross-sectional vertebral measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00298495
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  • 10
    Electronic Resource
    Electronic Resource
    When should bone density measurements be repeated? (1994)
    Springer
    Calcified tissue international 55 (1994), S. 243-248 
    Details
    ISSN: 1432-0827
    Keywords: Osteoporosis ; Bone density ; Longitudinal studies ; Statistical models ; Decision models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract We calculated how long to wait before repeating bone mineral density (BMD) measurements to reassess fracture risk. Correlation results from serial measurements of 495 postmenopausal Japanese-American women were used to estimate 95% confidence intervals (CI) for future BMD. After 7 years of follow-up, BMD correlations with the initial measurement ranged between 0.81 and 0.94, depending on age group and measurement site. In this analysis, the period between measurements was defined as the time required for the lower 95% CI to fall below the BMD value corresponding to doubling of fracture risk. Progressive bone loss causes fracture risk to double after 10 years, on average. However, the 95% CIs indicate that a second BMD measurement will detect risk doubling after only 2 or 3 years for some women. For untreated, early postmenopausal women, the period between measurements was approximately 2–5 years for the radius and 4–6 years for the calcaneus, depending on the initial BMD level. The period was approximately 1 year longer for women age 60 and older. Treatments that halve the bone loss rate would increase the period by 1–3 years. In the absence of a second measurement of BMD, the CI will continue to expand with time, corresponding to a wider range in risk between individuals, and a greater proportion of women will be at increased fracture risk. Obtaining a second BMD measurement pinpoints the patient's status within the precision of the measurement. We conclude that repeated BMD measurements will provide a more accurate estimate of fracture risk than a single, baseline measurement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310399
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