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1

Digitale Medien

Influence of gene dosage and autoregulation of the regulatory genes INO2 and INO4 on inositol/choline-repressible gene transcription in the yeast Saccharomyces cerevisiae (1997)

Schwank, Sabine ; Hoffmann, Brigitte ; Schüller, H.-J.

Springer

Current genetics 31 (1997), S. 462-468

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ISSN: 1432-0983

Schlagwort(e): Key words Transcriptional regulation ; Phospholipid biosynthesis ; Saccharomyces cerevisiae ; INO2

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract Expression of structural genes of phospholipid biosynthesis in yeast is mediated by the inositol/choline-responsive element (ICRE). ICRE-dependent gene activation, requiring the regulatory genes INO2 and INO4, is repressed in the presence of the phospholipid precursors inositol and choline. INO2 and, to a less extent, INO4 are positively autoregulated by functional ICRE sequences in the respective upstream regions. However, an INO2 allele devoid of its ICRE functionally complemented an ino2 mutation and completely restored inositol/choline regulation of Ino2p-dependent reporter genes. Low-level expression of INO2 and INO4 genes, each under control of the heterologous MET25 promoter, did not alter the regulatory pattern of target genes. Thus, upstream regions of INO2 and INO4 are not crucial for transcriptional control of ICRE-dependent genes by inositol and choline. Interestingly, over-expression of INO2, but not of INO4, counteracted repression by phospholipid precursors. Possibly, a functional antagonism between INO2 and a negative regulator is the key event responsible for repression or de-repression.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s002940050231

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2

Digitale Medien

Cloning and DNA sequence analysis of pepQ, a prolidase gene from Lactobacillus delbrueckii subsp. lactis DSM7290 and partial characterization of its product (1995)

Stucky, Klaus ; Robert Klein, Jürgen ; Schüller, Andrea ; [weitere]

Springer

Molecular genetics and genomics 247 (1995), S. 494-500

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ISSN: 1617-4623

Schlagwort(e): Prolidase ; Metalloprotease ; Lactobacillus delbrueckii subsp. lactis ; Nucleotide sequence analysis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract From a genomic library of Lactobacillus delbrueckii subsp. lactis (DSM7290) DNA, in the low-copy-number vector pLG339, a recombinant clone was selected, which complemented a mutation in the prolidase gene (pepQ) of Escherichia coli UK173. Nucleotide sequence analysis revealed an open reading frame of 1104 nucleotides corresponding to a protein of 368 amino acids with a calculated pI of 4.64 and a molecular mass of 41087 Da. The start site of pepQ transcription was determined by primer extension analysis with mRNA prepared from L. delbrueckii. Based on homology of the gene product to various peptidases and on the substrate specificity determined, the peptidase was designated PepQ. The influence of various protease inhibitors and cations on peptidase activity indicated that PepQ is a metalloprotease. The absence of a membrane-spanning domain and a signal peptide sequence argues for a cytoplasmic localization of the enzyme.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00293152

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3

Digitale Medien

Fabrication of glassy carbon microstructures by pyrolysis of microfabricated polymeric precursorsThis work has been supported in part by the Office of Naval Research and the Defense Advanced Research Projects Agency. It used MRSEC Shared Facilities supported by the National Science Foundation (DMR-9400396). The authors thank Xiao-Mei Zhao for demonstrating microtransfer molding. (1997)

Schueller, Olivier J. A. ; Brittain, Scott T. ; Whitesides, George M.

Weinheim : Wiley-Blackwell

Advanced Materials 9 (1997), S. 477-480

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ISSN: 0935-9648

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Maschinenbau , Physik

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/adma.19970090604

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4

Digitale Medien

Die Massenspektren der Nikotin-N-Oxide und der mit Ihnen Verwandten Tetrahydrooxazine (1973)

Schüller, D. ; Harke, H.-P.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 7 (1973), S. 839-843

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ISSN: 0030-493X

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Beschreibung / Inhaltsverzeichnis: The mass spectra of the three nicotine-N-oxides are discussed, together with the spectra of tetrahydrooxazines. The compounds with an N-oxide function in the five membered ring partly rearrange thermally before electron-impact fragmentation.

Notizen: Die massenspektren der drei Nikotin-N-oxide werden zusammen mit den Spektren von Tetrahydrooxazinen diskutiert. Die Verbindungen mit N-Oxide-Ffunktion im 5-gliedrigen Ring lagern sich vor der Fragmentierung durch Elektronenstoß z.T. thermisch um.

Zusätzliches Material: 8 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/oms.1210070708

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5

Digitale Medien

Struktureller Zusammenhang von [(C6H5)4As]NdCl4·8H2O und NdCl3·6H2O: übergang vom Raumnetz zur Schicht (1983)

Urland, Werner ; Schwanitz-Schüller, Ulrich

Weinheim : Wiley-Blackwell

Zeitschrift für die chemische Industrie 95 (1983), S. 1031-1032

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ISSN: 0044-8249

Schlagwort(e): Chemistry ; General Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/ange.19830951239

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6

Digitale Medien

A search in the genome of Saccharomyces cerevisiae for genes regulated via stress response elements (1998)

Moskvina, E. ; Schüller, C. ; Maurer, C. T. C. ; [weitere]

New York, NY [u.a.] : Wiley-Blackwell

Yeast 14 (1998), S. 1041-1050

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ISSN: 0749-503X

Schlagwort(e): Saccharomyces cerevisiae ; STRE ; stress response ; genomics ; bioinformatics ; Life and Medical Sciences ; Genetics

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie

Notizen: Stress response elements (STREs, core consensus AG4 or C4T) have been demonstrated previously to occur in the upstream region of a number of genes responsive to induction by a variety of stress signals. This stress response is mediated by the homologous transcription factors Msn2p and Msn4p, which bind specifically to STREs. Double mutants (msn2 msn4) deficient in these transcription factors have been shown to be hypersensitive to severe stress conditions. To obtain a more representative overview of the set of yeast genes controlled via this regulon, a computer search of the Saccharomyces cerevisiae genome was carried out for genes, which, similar to most known STRE-controlled genes, exhibit at least two STREs in their upstream region. In addition to the great majority of genes previously known to be controlled via STREs, 69 open reading-frames were detected. Expression patterns of a set of these were examined by grid filter hybridization, and 14 genes were examined by Northern analysis. Comparison of the expression patterns of these genes demonstrates that they are all STRE-controlled although their detailed expression patterns differ considerably. © 1998 John Wiley & Sons, Ltd.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

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7

Digitale Medien

ADAPTIVE PARALLEL MULTIGRID SOLUTION OF 2D INCOMPRESSIBLE NAVIER-STOKES EQUATIONS (1997)

Wu, Jian ; Ritzdorf, Hubert ; Oosterlee, Kees ; [weitere]

Chichester : Wiley-Blackwell

International Journal for Numerical Methods in Fluids 24 (1997), S. 875-892

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ISSN: 0271-2091

Schlagwort(e): adaptive parallel multigrid method ; local refinement criteria ; incompressible Navier-Stokes equations ; hole pressure problem ; Engineering ; Numerical Methods and Modeling

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Maschinenbau

Notizen: In this paper an adaptive parallel multigrid method and an application example for the 2D incompressible Navier-Stokes equations are described. The strategy of the adaptivity in the sense of local grid refinement in the multigrid context is the multilevel adaptive technique (MLAT) suggested by Brandt. The parallelization of this method on scalable parallel systems is based on the portable communication library CLIC and the message-passing standards: PARMACS, PVM and MPI. The specific problem considered in this work is a two-dimensional hole pressure problem in which a Poiseuille channel flow is disturbed by a cavity on one side of the channel. Near geometric singularities a very fine grid is needed for obtaining an accurate solution of the pressure value. Two important issues of the efficiency of adaptive parallel multigrid algorithms, namely the data redistribution strategy and the refinement criterion, are discussed here. For approximate dynamic load balancing, new data in the adaptive steps are redistributed into distributed memories in different processors of the parallel system by block remapping. Among several refinement criteria tested in this work, the most suitable one for the specific problem is that based on finite-element residuals from the point of view of self-adaptivity and computational efficiency, since it is a kind of error indicator and can stop refinement algorithms in a natural way for a given tolerance. Comparisons between different global grids without and with local refinement have shown the advantages of the self-adaptive technique, as this can save computer memory and speed up the computing time several times without impairing the numerical accuracy. © 1997 By John Wiley & Sons, Ltd. Int. J. Numer. Methods Fluids 24, 875-892, 1997.

Zusätzliches Material: 13 Ill.

Materialart: Digitale Medien

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8

Digitale Medien

Structural Relationship of [(C6H5)4As]NdCl4·8H2O and NdCl3·6H2O: Transition from a Three-Dimensional to a Layer Structure (1983)

Urland, Werner ; Schwanitz-Schüller, Ulrich

Weinheim : Wiley-Blackwell

Angewandte Chemie International Edition in English 22 (1983), S. 1009-1010

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ISSN: 0570-0833

Schlagwort(e): Chemistry ; General Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: No Abstract.The complete manuscript of this communication appears in: Angew. Chem. Suppl. 1983, 1399. DOI:10.1002/anie.198313990

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/anie.198310091

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9

Digitale Medien

Struktureller Zusammenhang von [(C6H5)4As] NdCl4·8H2O und NdCl3·6H2O: Übergang vom Raumnetz zur Schicht (1983)

Urland, Werner ; Schwanitz-Schüller, Ulrich

Weinheim : Wiley-Blackwell

Angewandte Chemie International Edition in English 22 (1983), S. 1399-1408

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ISSN: 0570-0833

Schlagwort(e): Chemistry ; General Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/anie.198313990

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