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  • Articles  (13)
  • Articles: DFG German National Licenses  (13)
  • Nature Publishing Group  (12)
  • Blackwell Science Ltd.  (1)
  • 2000-2004  (1)
  • 1950-1954  (9)
  • 1940-1944  (3)
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  • Articles  (13)
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  • Articles: DFG German National Licenses  (13)
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  • 1
    Electronic Resource
    Electronic Resource
    The Fap1 fimbrial adhesin is a glycoprotein: antibodies specific for the glycan moiety block the adhesion of Streptococcus parasanguis in an in vitro tooth model (2002)
    Oxford, UK : Blackwell Science Ltd.
    Molecular microbiology 43 (2002), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Streptococcus parasanguis is a primary colonizer of the tooth surface and plays a pivotal role in the formation of dental plaque. The fimbriae of S. parasanguis are important in mediating adhesion to saliva-coated hydroxylapatite (SHA), an in vitro tooth adhesion model. The Fap1 adhesin has been identified as the major fimbrial subunit, and recent studies suggest that Fap1 is a glycoprotein. Monosaccharide analysis of Fap1 purified from the culture supernatant of S. parasanguis indicated the presence of rhamnose, glucose, galactose, N-acetylglucosamine and N-acetylgalactosamine. A glycopeptide moiety was isolated from a pronase digest of Fap1 and purified by immunoaffinity chromatography. The monosaccharide composition of the purified glycopeptide was similar to that of the intact molecule. The functionality of the glycan moiety was determined using monoclonal antibodies (MAbs) specific for the intact Fap1 glycoprotein. These antibodies were grouped into two categories based on their ability to block adhesion of S. parasanguis to SHA and their corresponding specificity for either protein or glycan epitopes of the Fap1 protein. ‘Non-blocking’ MAb epitopes were mapped to unique protein sequences in the N-terminus of the Fap1 protein using non-glycosylated recombinant Fap1 proteins (rFap1 and drFap1) expressed in Escherichia coli. In contrast, the ‘blocking’ antibodies did not bind to the recombinant Fap1 proteins, and were effectively competed by the binding to the purified glycopeptide. These data suggest that the ‘blocking’ antibodies are specific for the glycan moiety and that the adhesion of S. parasanguis is mediated by sugar residues associated with Fap1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.2002.02725.x
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  • 2
    Electronic Resource
    Electronic Resource
    Life-time of the Lithium Atomic Resonance States (1951)
    [s.l.] : Nature Publishing Group
    Nature 167 (1951), S. 156-156 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Ladenburg absorption formula3 relating the integral of the absorption coefficient over the whole line to the Einstein transition probability coefficient Anm may be conveniently put in the form loge(I0/IV)dl(1)pNƒe2ll02/mc2 (1) where N is the number of normal atoms of absorbing vapour per ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/167156a0
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  • 3
    Electronic Resource
    Electronic Resource
    Marine Biological Research in Great Britain (1944)
    [s.l.] : Nature Publishing Group
    Nature 154 (1944), S. 300-300 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE letter published in Nature of July 29 from Prof. F. E. Fritsch opens an important subject which has been in the minds of a number of zoologists during the past few years, and it is one in connexion with which some of us would be extremely glad to see action taken on the lines which Prof. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/154300a0
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  • 4
    Electronic Resource
    Electronic Resource
    Possible Role of Proteolytic Enzymes in Protein Synthesis (1953)
    [s.l.] : Nature Publishing Group
    Nature 171 (1953), S. 1024-1025 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] As a test of this hypothesis, Hendler and Green-berg5 have recently studied the metabolism of labelled y-glutamyl-glycine; but they found that this particular compound is not significantly involved in any of several living systems that incorporate amino-acids into proteins. The evidence presented ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1711024a0
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  • 5
    Electronic Resource
    Electronic Resource
    Experimental Determination of the Life-times of Atomic Resonance States (1951)
    [s.l.] : Nature Publishing Group
    Nature 167 (1951), S. 112-112 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Further work is progressing with the view of adapting the method to molecular transitions, and the results will be reported at a later date. Atom Transition Wave-length Life-time (sec.) Na 32S-32P 5896, 5890 A. 1.61 0.06 x 10-8 K 42S-42P 7699, 7665 2.71 0.09 x 10-8 Rb 52S-52P 7947, 7800 2.81 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/167112a0
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  • 6
    Electronic Resource
    Electronic Resource
    Presence and Absence of the Pre-Natal Check in Lambs' Birthcoats (1954)
    [s.l.] : Nature Publishing Group
    Nature 173 (1954), S. 878-879 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sickle-fibres constitute the most easily perceived evidence of the pre-natal check3-5. Of ten N/ + Aggrade lambs studied in a number of body regions, all had sickle-fibres on the shoulder patch and shoulder, and they were present on several necks, withers, sides and o backs, but not on any ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/173878b0
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  • 7
    Electronic Resource
    Electronic Resource
    Caution in the Use of Liquid Propane for freezing Biological Specimens (1954)
    [s.l.] : Nature Publishing Group
    Nature 174 (1954), S. 235-235 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] On one occasion when I was slowly condensing propane in a flask chilled with liquid nitrogen, I obtained what appeared to be such a mixture : that is, I obtained two distinct layers of liquid in the flask, one of which had the characteristic appearance of liquid oxygen. This experience suggested ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/174235b0
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  • 8
    Electronic Resource
    Electronic Resource
    Resistance of a Soil Nematode to Changes in Osmotic Pressure (1942)
    [s.l.] : Nature Publishing Group
    Nature 149 (1942), S. 500-500 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE results detailed below are considered to be of sufficient interest to merit early publication. An amplified account will be published in the future, when a description will be given of the species of Rhabditis which was employed. The worms were cultured in an agar broth the osmotic pressure ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/149500a0
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  • 9
    Electronic Resource
    Electronic Resource
    Oscillator Strength of the Na 2 1 Σ— 1 Σ Transitions (1950)
    [s.l.] : Nature Publishing Group
    Nature 166 (1950), S. 191-192 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/166191b0
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  • 10
    Electronic Resource
    Electronic Resource
    Masses of Fundamental Particles (1950)
    [s.l.] : Nature Publishing Group
    Nature 165 (1950), S. 1018-1018 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Substituting for M% the present value 1837 '56 m for the mass of the neutral hydrogen atom, it is found that MX is 1839-08 m, in excellent agreement with the experimental neutron mass 1839-05 m. This simple relation between the neutron and hydrogen atom is consistent with Eddington's1 concept of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1651018c0
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