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  • Articles  (5)
  • Articles: DFG German National Licenses  (5)
  • Springer  (5)
  • 2020-2023
  • 1985-1989  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Investigational new drugs 4 (1986), S. 289-293 
    ISSN: 1573-0646
    Keywords: flavone acetic acid ; cytotoxicity ; colon cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Flavone acetic acid (FAA) was incubated for 1 to 48 hr with 3 established human colon cancer cell lines endowed with distinct degrees of phenotypic properties. All 3 lines responded to FAA in almost identical fashion; when incubated with the drug for only 1 hr, an initial decrease in survival was observed for concentrations of 250 μg/ml but no further increments in cytotoxicity were elicited when the concentration of FAA was augmented. Increasing the length of treatment yielded relatively modest increments (about 1 log) in cell killing only after an interval of 48 hr and only at the highest concentration (1000 μg/ml). Because of these relatively poor cytotoxic effects and because the therapeutic range of FAA is so narrow, we conclude that this agent will not be a valuable contribution to the antitumor arsenal, at least for colon cancer.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Origins of life and evolution of the biospheres 16 (1986), S. 275-276 
    ISSN: 1573-0875
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Origins of life and evolution of the biospheres 19 (1989), S. 258-259 
    ISSN: 1573-0875
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1572-9591
    Keywords: blanket ; lithium ; neutronics ; tokamak ; tritium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The Lithium Blanket Module (LBM) is an approximately 80×80×80 cm cubic module, representative of a helium-cooled lithium oxide fusion reactor blanket module, that will be installed on the TFTR (Tokamak Fusion Test Reactor) in late 1986. The principal objective of the LBM Program is to perform a series of neutron transport and tritium-breeding measurements throughout the LBM when it is exposed to the TFTR toroidal fusion neutron source, and to compare these data with the predictions of Monte Carlo (MCNP) neutronics codes. The LBM consists of 920 2.5-cm diameter breeder rods constructed of lithium oxide (Li2O) pellets housed in thin-walled stainless steel tubes. Procedures for mass-producing 25,000 Li2O pellets with satisfactory reproducibility were developed using purified Li2O powder, and fabrication of all the breeder rods was completed in early 1985. Tritium assay methods were investigated experimentally using both small lithium metal samples and LBM-type pellets. This work demonstrated that the thermal extraction method will be satisfactory for accurate evaluation of the minute concentrations of tritium expected in the LBM pellets (0.1–1 nCi/g).
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 62 (1989), S. 449-466 
    ISSN: 1573-2878
    Keywords: Cone concavity ; strong maximal points ; dual problems ; strong saddlepoints ; pseudotangent cones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract LetX,Y andZ be locally convex real topological vector spaces,A⊂X a convex subset, and letC⊂Y,E⊂Z be cones. Letf:X→Z beE-concave andg:X→Y beC-concave functions. We consider a concave programming problem with respect to an abstract cone and its strong dual problem as follows: $$\begin{gathered} (P)maximize f(x), subject to x \in A, g(x) \in C, \hfill \\ (SD)minimize \left\{ {\mathop \cup \limits_{\varphi \in C^ + } \max \{ (f + \varphi \circ g)(A):E\} } \right\}, \hfill \\ \end{gathered} $$ , whereC + denotes the set of all nonnegative continuous linear operators fromY toZ and (SD) is the strong dual problem to (P). In this paper, the authors find a necessary condition of strong saddle point for Problem (P) and establish the strong duality relationships between Problems (P) and (SD).
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