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  • Articles  (144)
  • Articles: DFG German National Licenses  (144)
  • Springer  (124)
  • Annual Reviews  (20)
  • American Meteorological Society
  • Elsevier
  • 2010-2014
  • 2000-2004  (16)
  • 1960-1964
  • 1955-1959  (128)
  • 1920-1924
  • 2002  (16)
  • 1957  (128)
  • Medicine  (110)
  • Mathematics  (34)
  • 1
    Electronic Resource
    Electronic Resource
    OVULATION: New Dimensions and New Regulators of the Inflammatory-Like Response (2002)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 64 (2002), S. 69-92 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract Ovulation is a complex process that is initiated by the lutenizing hormone surge and is controlled by the temporal and spatial expression of specific genes. This review focuses on recent endocrine, biochemical, and genetic information that has been derived largely from the identification of new genes that are expressed in the ovary, and from knowledge gained by the targeted deletion of genes that appear to impact the ovulation process. Two main areas are described in most detail. First, because mutant mouse models indicate that appropriate formation of the cumulus matrix is essential for successful ovulation, genes expressed in the cumulus cells and those that control cumulus expansion are discussed. Second, because mice null for the progesterone receptor fail to ovulate and are ideal models for dissecting the critical events downstream of progesterone receptor, genes expressed in mural granulosa cells that regulate the expression of novel proteases are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.physiol.64.081501.131029
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  • 2
    Electronic Resource
    Electronic Resource
    THE CHANGING FACE OF THE Na+/H+ EXCHANGER, NHE1: Structure, Regulation, and Cellular Actions (2002)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 42 (2002), S. 527-552 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: Abstract The NHE family of ion exchangers includes six isoforms (NHE1-NHE6) that function in an electroneutral exchange of intracellular H+ for extracellular Na+. This review focuses on the only ubiquitously expressed isoform, NHE1, which is localized at the plasma membrane where it plays a critical role in intracellular pH (pHi) and cell volume homeostasis. All NHE isoforms share a similar topology: an N-terminus of 12 transmembrane (TM) alpha-helices that collectively function in ion exchange, and a C-terminal cytoplasmic regulatory domain that modulates transport activity by the TM domain. Extracellular signals, mediated by diverse classes of cell-surface receptors, regulate NHE1 activity through distinct signaling networks that converge to directly modify the C-terminal regulatory domain. Modifications in the C-terminus, including phosphorylation and the binding of regulatory proteins, control transport activity by altering the affinity of the TM domain for intracellular H+. Recently, it was determined that NHE1 also functions as a membrane anchor for the actin-based cytoskeleton, independently of its role in ion translocation. Through its effects on pHi homeostasis, cell volume, and the actin cortical network, NHE1 regulates a number of cell behaviors, including adhesion, shape determination, migration, and proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pharmtox.42.092001.143801
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  • 3
    Electronic Resource
    Electronic Resource
    Steady shear flow of non-Newtonian fluids (1957)
    Springer
    Archive for rational mechanics and analysis 1 (1957), S. 410-417 
    Details
    ISSN: 1432-0673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00298018
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  • 4
    Electronic Resource
    Electronic Resource
    Pneumomicosi cronica (Aspergillosi?) con generalizzazione pluriviscerale (1957)
    Springer
    Mycopathologia 8 (1957), S. 27-46 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Résumé Les AA. décrivent un cas de pneumomycose chronique, avec généralisation pluriviscérale tout à fait exceptionnelle. A cause de ce tableau clinique et anatomique si extraordinaire, qui n'à pas encore été signalé dans la litérature, il n'à été possible d'en établir le diagnostic qu'au moyen de l'examen histologique des lésions.
    Abstract: Zusammenfassung Die Verfasser beschreiben einen Fall von chronischer Pneumomykose mit absolut ausserordentlicher plurivisceraler Generalisation. Infolge des ungewöhnlichen, klinischen und anatomischen Bildes, das bis heute in der Literatur nicht erwähnt worden ist, hat die Krankheit nur durch die histologische Beobachtung der Veränderungen diagnostiziert werden können.
    Notes: Riassunto Gli AA. descrivono un caso di pneumomicosi cronica, con generalizzazione pluriviscerale, assolutamente eccezionale. Per causa dell'insolito quadro clinico ed anatomico, che non ha riscontro nella letteratura, la natura della malattia non potè essere diagnosticata che con l'esame istologico delle lesioni.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02053116
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  • 5
    Electronic Resource
    Electronic Resource
    Successful infection of pigeons and chickens with Histoplasma capsulatum (1957)
    Springer
    Mycopathologia 8 (1957), S. 189-193 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The first repeatedly successful infection withHistoplasma capsulatium of pigeons and chickens is reported. From 44 intravenously infected pigeonsHistoplasma capsulatum could be recovered by culture in 20 cases as long as 45 days after injection; from 10 chickens 5 positive cultures were obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02052831
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  • 6
    Electronic Resource
    Electronic Resource
    Action potentials of respiratory musculature in patients having respiratory deficiency (1957)
    Springer
    Bulletin of experimental biology and medicine 43 (1957), S. 580-583 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Normal action potentials in respiratory muscles were studied. Then these were compared with action potentials observed in patients, chiefly those ill with bronchial asthma and pulmonary emphysema. It was noted that the muscles of the patients registered a marked rise in activity even when the usual external indicators such as rate, depth and pulmonary ventilation appeared to be near normal. This was taken to indicate that the respiratory center was belrg subjected to compensatory stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00785742
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  • 7
    Electronic Resource
    Electronic Resource
    CHROMOSOME-MICROTUBULE INTERACTIONS DURING MITOSIS (2002)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Cell and Developmental Biology 18 (2002), S. 193-219 
    Details
    ISSN: 1081-0706
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Spindle microtubules interact with mitotic chromosomes, binding to their kinetochores to generate forces that are important for accurate chromosome segregation. Motor enzymes localized both at kinetochores and spindle poles help to form the biologically significant attachments between spindle fibers and their cargo, but microtubule-associated proteins without motor activity contribute to these junctions in important ways. This review examines the molecules necessary for chromosome-microtubule interaction in a range of well-studied organisms, using biological diversity to identify the factors that are essential for organized chromosome movement. We conclude that microtubule dynamics and the proteins that control them are likely to be more important for mitosis than the current enthusiasm for motor enzymes would suggest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.cellbio.18.032002.132412
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  • 8
    Electronic Resource
    Electronic Resource
    Developmental Physiology (1957)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 19 (1957), S. 41-58 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.19.030157.000353
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  • 9
    Electronic Resource
    Electronic Resource
    ADVANCES IN PROTEOMIC TECHNOLOGIES (2002)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biomedical Engineering 4 (2002), S. 349-373 
    Details
    ISSN: 1523-9829
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Technology , Medicine
    Notes: Abstract Proteomics is a rapidly emerging set of key technologies that are being used to identify proteins and map their interactions in a cellular context. With the sequencing of the human genome, the scope of proteomics has shifted from protein identification and characterization to include protein structure, function and protein-protein interactions. Technologies used in proteomic research include two-dimensional gel electrophoresis, mass spectrometry, yeast two-hybrids screens, and computational prediction programs. While some of these technologies have been in use for a long time, they are currently being applied to study physiology and cellular processes in high-throughput formats. It is the high-throughput approach that defines and characterizes modern proteomics. In this review, we discuss the current status of these experimental and computational technologies relevant to the three major aspects of proteomics-characterization of proteomes, identification of proteins, and determination of protein function. We also briefly discuss the development of new proteomic technologies that are based on recent advances in analytical and biochemical techniques, engineering, microfabrication, and computational prowess. The integration of these advances with established technologies is invaluable for the drive toward a comprehensive understanding of protein structure and function in the cellular milieu.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.bioeng.4.020702.153443
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  • 10
    Electronic Resource
    Electronic Resource
    Tissue Metabolism (Pharmacological Aspects) (1957)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 19 (1957), S. 121-150 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.19.030157.001005
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