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The auricular myocardiocytes of the heart constitute an endocrine organ characterization of a porcine cardiac peptide hormone, cardiodilatin-126 (1984)

Forssmann, W. G. ; Birr, C. ; Carlquist, M. ; [et al.]

Springer

Cell & tissue research 238 (1984), S. 425-430

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ISSN: 1432-0878

Keywords: Heart, atrium ; Myoendocrine cells ; Cardiodilatin ; Peptide hormone ; Immunohistochemistry ; Pig

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary A peptide hormone was extracted from the porcine right atrium following a bioassay for differential vaso-relaxant effects on smooth muscle strips from aorta and renal and inferior mesenteric arteries. The isolation procedure included several steps of gel-permeation and ion-exchange chromatography, and high performance liquid chromatography. During the isolation procedure, other peptides of smaller molecular weight were also found, which, in relation to cardiodilatin-126 (CDD-126), are shorter at their N-terminal. Among these, CDD-88 has also been isolated and characterizied, and has been established as a prominent member of the cardiac hormone family. The N-terminal and C-terminal segments of the 126 amino acid-containing molecule were synthesized and used to raise region-specific antibodies. The natural peptide was then localized within myoendocrine cells of the right atrium where specific atrial granules are located. Renal effects of cardiodilation were studied in conscious dogs and showed strong diuretic and natriuretic activities. According to our functional studies, cardiodilatin-126 and cardiodilatin-88 possess qualities of a significant hormone family regarding the regulation of extracellular fluid volume and blood pressure.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00219856

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Sperm head structure in the hydromyinae (rodentia:Muridae): A further evolutionary development of the subacrosomal space in mammals (1984)

Breed, W. G.

New York, NY : Wiley-Blackwell

Gamete Research 10 (1984), S. 31-44

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ISSN: 0148-7280

Keywords: subacrosomal space ; sperm ; murid rodents ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: This scanning and transmission electron microscopical study has been performed to determine the extent of the development of the subacrosomal space in the sperm head of various members of the subfamily, the Hydromyinae, which is a diverse group of murid rodents occurring in various habitats in Australia. Sperm of all species from the three tribes of Hydromyini, Uromyini, and Conilurini investigated in this study had a head with three hooks although their absolute and relative lengths varied markedly. The top hook was similar in structure to that present in many other murid rodents and had a typical pseudoperforatorium present. The two ventral hooks had nuclear material basally, apical to which a large extension of the subacrosomal space occurred. Studies of testicular sections showed that the ventral hooks were formed late in spermiogenesis largely after condensation of the nucleus during which time electron dense material accumulated within them. No structure homologous to these hooks has been found in sperm from any other mammalian group, but, as the three tribes of Hydromyinae probably diverged about 20 million years ago, the extension of the subacrosomal space presumably evolved prior to this date.

Additional Material: 41 Ill.