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  • Books  (9)
  • E-Books: Biomedical and Life Sciences (AWI only)  (9)
  • 2020-2024  (9)
  • 2010-2014
  • 2005-2009
  • 2020  (9)
  • 1
    Online Resource
    Online Resource
    Translational Neuroscience of Speech and Language Disorders (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Translational Neuroscience of Speech and Language Disorders: State of the Art. -2. Translational Neuroscience of Aphasia and Adult Language Rehabilitation. -3. Treatment and intervention approaches for the improvement of language abilities in neurodegenerative diseases -- 4. Neural and Genetic Mechanisms of Dyslexia -- 5. The role of memory systems in neurodevelopmental disorders of language -- 6. Transcranial direct current stimulation (tDCS) and Language/Speech: Can patients benefit from a combined therapeutic approach? -- 7. Transcranial Magnetic Stimulation in Aphasia Rehabilitation -- 8. The Cerebellum: A Therapeutic Target in Treating Speech and Language Disorders -- 9. Navigated rTMS for Mapping the Language Network in Preoperative Settings: Current Status and Future Prospects -- 10. Presurgical Language fMRI in Epilepsy: An Introduction -- 11. Lesion-symptom mapping in speech and language disorders: a translational perspective.
    Abstract: This edited volume provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative conditions on speech and language. It brings together contributions from several leading experts in a markedly broad range of disciplines, including Speech and Language Therapy, Neuropsychology and Neurology, but also Neurosurgery, Neuroimaging and Neurostimulation, as well as Engineering and Genetics.
    Type of Medium: Online Resource
    Pages: XVII, 290 p. 18 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356873
    Series Statement: Contemporary Clinical Neuroscience,
    URL: https://doi.org/10.1007/978-3-030-35687-3
    DOI: 10.1007/978-3-030-35687-3
    DDC: 612.8
    Language: English
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  • 2
    Online Resource
    Online Resource
    Heparanase : From Basic Research to Clinical Applications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Abstract: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Type of Medium: Online Resource
    Pages: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345211
    Series Statement: Advances in Experimental Medicine and Biology, 1221
    URL: https://doi.org/10.1007/978-3-030-34521-1
    DOI: 10.1007/978-3-030-34521-1
    DDC: 571.978
    Language: English
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  • 3
    Online Resource
    Online Resource
    Proteostasis and Disease : From Basic Mechanisms to Clinics (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Neurosciences. ; Immunology. ; Medicine Research. ; Biology Research. ; Cancer. ; Cell Biology. ; Neuroscience. ; Immunology. ; Biomedical Research. ; Cancer Biology.
    Description / Table of Contents: Part I. Cancer -- Ubiquitin-Regulated Cell Proliferation and Cancer -- Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer -- The Proteasome System in Health and Disease -- Proteostasis Dysregulation in Pancreatic Cancer -- Divergent Modulation of Proteostasis in Prostate Cancer -- Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma -- Part II. Neurodegeneration -- Altered Proteostasis in Neurodegenerative Tauopathies -- The Ubiquitin System in Alzheimer’s Disease -- The Interplay Between Proteostasis Systems and Parkinson’s Disease -- Machado–Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides -- Part III. Infection, Inflammation and Developmental Disorders -- SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends -- The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication -- By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System -- TRIM E3 Ubiquitin Ligases in Rare Genetic Disorders -- Part IV. Diet -- We Are What We Eat: Ubiquitin–Proteasome System (UPS) Modulation Through Dietary Products.
    Abstract: This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
    Type of Medium: Online Resource
    Pages: XII, 348 p. 42 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030382667
    Series Statement: Advances in Experimental Medicine and Biology, 1233
    URL: https://doi.org/10.1007/978-3-030-38266-7
    DOI: 10.1007/978-3-030-38266-7
    DDC: 571.6
    Language: English
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  • 4
    Online Resource
    Online Resource
    Neuroendocrine Clocks and Calendars (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Endocrine glands. ; Neuroscience. ; Endocrine System.
    Description / Table of Contents: Photoperiodism and Circannual Timing: Introduction and Historical Perspective.-The Pars Tuberalis and Seasonal Timing -- Tanycytes and Their Pivotal Role in Seasonal Physiological Adaptations -- Epigenetic Mechanisms in Developmental and Seasonal Programs -- Plasticity of Neuroendocrine Mechanisms Regulating Seasonal Reproduction in Sheep -- Clocks and Calendrars in Birds -- Calendar Timing in Teleost Fish -- Action of Light on the Neuroendocrine Axis -- Seasons, Clocks, and Mood -- Photoperiodic Modulation of Clock Gene Expression in the SCN -- Circadian Timekeeping in the Suprachiasmatic Nucleus: Genes, Neurotransmitters, Neurons and Astrocytes. .
    Abstract: This book explores how daily and seasonal rhythmicity is generated, how these rhythms are synchronised by our environment, and how they regulate the neuroendocrine systems that impact our physiology and behaviour. The constraints of surviving in a seasonal environment have shaped human evolution and migration, have shaped our societies and cultures, and continue to influence our everyday lives, health and wellbeing. Identifying the mechanisms whereby seasonal rhythmicity is generated and regulates the brain and body is not only important for understanding the natural world and relevant to animal production, it also offers many insights into the human condition. Each chapter is written by an international expert in the field of chronobiology. A historical perspective on how research into photoperiodism and rhythmicity progressed is initially provided, but the main focus of this book is on the remarkable studies in the last few decades that have unravelled the molecular and cellular machinery underpinning circadian and circannual timing. Topics covered include the role of melatonin in communicating seasonal information to the brain and pituitary gland, the neuroanatomical pathways in mammals, birds and fish by which changes in photoperiod reach the hypothalamus, the role of glial cells (tanycytes) and thyroid hormone in seasonal rhythmicity, neuroplasticity across seasons, effects of changing day length on mood, regulation of “clock“ gene expression, and the role of the suprachiasmatic nucleus. This book will appeal to all students and researchers who wish to learn about current and past research on daily and seasonal rhythmicity. This is the tenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. .
    Type of Medium: Online Resource
    Pages: XII, 244 p. 64 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030556433
    Series Statement: Masterclass in Neuroendocrinology, 10
    URL: https://doi.org/10.1007/978-3-030-55643-3
    DOI: 10.1007/978-3-030-55643-3
    DDC: 612.8
    Language: English
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  • 5
    Online Resource
    Online Resource
    Mercury and the Everglades. A Synthesis and Model for Complex Ecosystem Restoration : Volume III – Temporal Trends of Mercury in the Everglades, Synthesis and Management Implications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Ecology . ; Biotic communities. ; Pollution. ; Water. ; Hydrology. ; Ecology. ; Ecosystems. ; Pollution. ; Water.
    Abstract: This book is the final installation in a three-volume series synthesizing 30 years of mercury research in the Florida Everglades. The first part of this book evaluates the occurrence of trends in both biota mercury concentrations and atmospheric mercury deposition. Through both empirical and deterministic analyses, the likely drivers of biota trends are identified. These analyses help lay the predicate for devising an overall strategy to mitigate and manage the Everglades mercury problem. The book concludes with a model analysis of the likely benefits and uncertainty attendant with implementing the leading candidate strategy for best reducing the Everglades mercury problem.
    Type of Medium: Online Resource
    Pages: XV, 164 p. 78 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030556358
    URL: https://doi.org/10.1007/978-3-030-55635-8
    DOI: 10.1007/978-3-030-55635-8
    DDC: 577
    Language: English
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  • 6
    Online Resource
    Online Resource
    Design of Experiments and Advanced Statistical Techniques in Clinical Research (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Statistics . ; Biometry. ; Biomedical Research. ; Applied Statistics. ; Biostatistics.
    Description / Table of Contents: Design of Clinical Research and its Practical Approach -- Advanced Design of Experiment Approach to Clinical and Medical Research -- Random Forest and Concept of Decision Tree Model -- Application of Machine Learning in Medical Research -- Statistical Genetic and its Application in Drug Trail -- Statistical Implications for Estimation of Genetic Traits in Human Vaccine Trail -- Statistical Implications and its Practical Approach to Research Methodology -- Statistical Models Approach to Life Threatened Diseases -- Meta Analysis in Clinical and Life Science Research -- Pharmokinitic and Statistical Modelling -- Imputation Methods Approach to Clinical and Life Science Research Data Sets -- Ethical Perspective of Medical Research.
    Abstract: Recent Statistical techniques are one of the basal evidence for clinical research, a pivotal in handling new clinical research and in evaluating and applying prior research. This book explores various choices of statistical tools and mechanisms, analyses of the associations among different clinical attributes. It uses advanced statistical methods to describe real clinical data sets, when the clinical processes being examined are still in the process. This book also discusses distinct methods for building predictive and probability distribution models in clinical situations and ways to assess the stability of these models and other quantitative conclusions drawn by realistic experimental data sets. Design of experiments and recent posthoc tests have been used in comparing treatment effects and precision of the experimentation. This book also facilitates clinicians towards understanding statistics and enabling them to follow and evaluate the real empirical studies (formulation of randomized control trial) that pledge insight evidence base for clinical practices. This book will be a useful resource for clinicians, postgraduates scholars in medicines, clinical research beginners and academicians to nurture high-level statistical tools with extensive scope.
    Type of Medium: Online Resource
    Pages: XXXV, 356 p. 190 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811582103
    URL: https://doi.org/10.1007/978-981-15-8210-3
    DOI: 10.1007/978-981-15-8210-3
    DDC: 610.72
    Language: English
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  • 7
    Online Resource
    Online Resource
    The Science and Business of Drug Discovery : Demystifying the Jargon (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacovigilance. ; Pharmaceutical chemistry. ; Chemistry, Physical and theoretical. ; Biotechnology. ; Pharmacology. ; Drug Safety and Pharmacovigilance. ; Pharmaceutics. ; Theoretical Chemistry. ; Biotechnology.
    Description / Table of Contents: Introduction -- PART 1: How Drugs are Discovered and Developed in the Pharmaceutical Industry -- Introduction to Drugs and Drug Targets -- Background to chemistry of small and large molecules -- Laying the foundations- Drug discovery from antiquity to the twenty first century -- Part II-The drug development pipeline – discovery to testing in humans -- Drug discovery pipeline overview -- Target discovery -- Medicinal chemistry -- Biotherapeutics -- Screening for hits -- Process chemistry and formulation -- Preclinical development -- Part III-The drug development pipeline – clinical trials to marketing authorisation -- Clinical trials -- Regulatory affairs and marketing approval -- Diagnostics and personalized medicine -- Putting it All Together: a drug development case history -- Part IV- The Global Pharmaceuticals Business -- Commercial aspects of drug development -- Challenges and responses -- Part V - Professional Interactions with the Drug Discovery Industry.-Professional Interactions with the Drug Discovery Industry: Technology Transfer Executives -- Recruitment Executives -- Pharmaceutical translators and Interpreters.
    Abstract: The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators .
    Type of Medium: Online Resource
    Pages: XVII, 402 p. 102 illus., 20 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030578145
    URL: https://doi.org/10.1007/978-3-030-57814-5
    DOI: 10.1007/978-3-030-57814-5
    DDC: 615
    Language: English
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  • 8
    Online Resource
    Online Resource
    Pineal Neurosurgery (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Nervous system Surgery. ; Neurology . ; Neurosciences. ; Neurosurgery. ; Neurology. ; Neuroscience.
    Description / Table of Contents: Chapter 1 Embryology of the Pineal Gland -- Chapter 2 Anatomy of the Pineal Gland -- Chapter 3 Physiology of the Pineal Gland -- Chapter 4 Neuroimaging of the Pineal Gland -- Chapter 5 Tumors of the Pineal Gland -- Chapter 6 Non-tumorous Lesions of the Pineal Gland -- Chapter 7 Treatment and Approaches for the Pineal Gland Region -- Chapter 8 Interesting Cases of Pineal Gland Diseases and Surgery -- Chapter 9 Animal Based Surgical Training in Pineal Approaches -- Chapter 10 Evolutionary Retrace of the Third Eye.
    Abstract: This comprehensive book focuses on neurosurgical aspects of the pineal gland. By covering virtually all aspects of the pineal gland, it fills an important gap in the neurosurgical literature. Further, it approaches this vital component of the human brain from various angles: embryology, anatomy, physiology, pathology, radiology and surgical techniques. More than 70 single-best-answer multiple-choice questions (MCQs) are distributed throughout the chapters. Offering an essential review for residents and surgeons across neurosurgical disciplines and containing most of the critical information needed to prepare for both the primary and certification exam, the book will also be of interest to neurologists, neuroscientists and medical students. .
    Type of Medium: Online Resource
    Pages: XXVIII, 141 p. 42 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030531911
    URL: https://doi.org/10.1007/978-3-030-53191-1
    DOI: 10.1007/978-3-030-53191-1
    DDC: 617.48
    Language: English
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  • 9
    Online Resource
    Online Resource
    Resilience and Aging : Emerging Science and Future Possibilities (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Aging. ; Public health. ; Psychobiology. ; Human behavior. ; Psychology. ; Sociology. ; Ageing. ; Public Health. ; Behavioral Neuroscience. ; Behavioral Sciences and Psychology. ; Sociology.
    Description / Table of Contents: Chapter 1: Introduction: Perspectives of Resilience and Aging -- Chapter 2: Resilience in Older Adults: What it is and How to Strengthen It -- Chapter 3: Resilience in Later life: Responding to Criticisms and Applying New Knowledge to the Experience of Dementia -- Chapter 4: Science and Practice of Resilience: Disaster Systems Applications to Aging Model Development -- Chapter 5: Multimorbidity Resilience: Conceptual, Theoretical and Measurement Developments -- Chapter 6: Quantitative Approaches to Examine Resilience and Aging -- Chapter 7: Positive Affect as Source of Resilience in Adulthood and Later Life -- Chapter 8: Psychological Resilience in the Face of Later-Life Bereavement -- Chapter 9: Physical Resilience and Aging -- Chapter 10: Mobility Resilience Processes Among Older Adults -- Chapter 11: Communities and Resilience: Contextual and Collective Resilience -- Chapter 12: Advancing the Concept of Resilience for Older Adults who are Experiencing Homelessness.
    Abstract: Older aged adults face many adversities over the later life course. This edited volume will address the ways in which seniors bounce back from different types and combinations of adversity – termed “resilience”. While research has been accumulating that identifies inherent abilities and external resources needed to adapt and navigate stress-inducing experiences among aging and older adults, gaps remain in understanding the unique elements and processes of resilience. A series of chapters included in this book will address several overarching questions: why do some older individuals/families/communities adapt to adversity better than others; what are modifiable behavioral protective/risk factors related to resilience; and how can we foster resilience at the individual/community level and which approaches show the most promise? The spectrum of aging-related challenges and responses addressed in this book include: mental health; physical/functional health problems; multimorbidity; socio-economic deprivation; social isolation and loneliness; cultural dimensions of loneliness; housing/homelessness problems; and environmental disasters. This book presents cutting-edge science at the conceptual, methodological, empirical and practice levels applied to emerging resilience sub-fields in gerontology. It will also present potential areas of future research, policy and practice linked to these areas. During a period of the most rapid population aging in the US, Canada and many other nations, coupled with heightened global socio-political change, extending our knowledge of resilience will help society to make important adjustments to maximize health and wellness of older individuals. Supporting and enhancing resilience through technological, social and/or community-level advances in geroscience will help those facing adversity to thrive by harnessing, stretching, and leveraging a wide array of potential resources. The promotion of healthier older populations has far-reaching consequences for health care and social/community support systems, both in terms of public health including pandemic response, and the development and implementation of innovations in treatment and practice guidelines.
    Type of Medium: Online Resource
    Pages: IX, 275 p. 28 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030570897
    Series Statement: Risk, Systems and Decisions,
    URL: https://doi.org/10.1007/978-3-030-57089-7
    DOI: 10.1007/978-3-030-57089-7
    DDC: 571.878
    Language: English
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