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  • 1
    Publication Date: 2024-04-14
    Description: The aim of the book is to assist both local and international scholars in articulating the scholarly discourse on indigenous health attitudes, practices, and experiences. The indigenous lens that was used to generate and disseminate indigenous knowledge in this book will strengthen indigenous scholarship, thus making it accessible to a wider audience. In addition, the information shared in this book will add value for scholars and assist them with the indigenous knowledge needed to address sustainable development goals. This book is timeous and topical as the discourse on the decolonisation of the curriculum is widely debated in the higher education space. The discourse on the scholarship of indigenous knowledge, as the tacit local knowledge that stems from cultural practices within communities, has not been well articulated in the current health science education milieu. Indigenous knowledge has remained overlooked and undermined for a very long time and the information remains untapped in local communities. The scholars who conducted the research on which this book is based unearthed a wealth of knowledge which was tacit in nature and translated it into implicit knowledge that can be documented and shared with other scholars globally. This knowledge will assist health care scholars in benefiting from knowledge, practices and cultural beliefs that will assist them in health care planning, teaching, evidence-based practice and further research.
    Keywords: Indigenous knowledge system ; integrative health care ; indigenous women’s health ; culture ; traditional health care ; health care ; health care professionals ; thema EDItEUR::V Health, Relationships and Personal development::VF Family and health::VFD Popular medicine and health::VFDW Women’s health ; thema EDItEUR::V Health, Relationships and Personal development::VF Family and health::VFD Popular medicine and health::VFDW Women’s health
    Language: English
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  • 2
    Publication Date: 2023-03-21
    Description: This book intends to provide a continuous assessment of the crisis in governance in Africa. As it is, there are huge deficits in the capacity of African states to harness vast human and material resources to promote good governance. This manifests in pervasive corruption, collapsed service delivery, collapsed state-owned enterprises, eroded social trust, capital flight, escalating levels of poverty and wars, human insecurity, and stunted growth. The public sector is the pulse of service delivery because the entire governance system revolves around the sourcing of materials and services, mostly from the private sector, in order to achieve its public policy intents. The procurement process, therefore, ordinarily ought to yield positive economic outcomes and an efficiency-driven system in favour of the government itself and its service recipients. However, this more often than not is not the case. Despite its enormous wealth, the African continent is in an economic quagmire, a dilemma that requires multi-facet research activities. This is the motivation for this book.
    Keywords: Accountability ; procurement ; corruption ; maladministration ; service delivery ; socio-economic development ; state-owned enterprises ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCN Environmental economics
    Language: English
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  • 3
    Publication Date: 2023-12-20
    Description: Climate change will bring about significant changes to the capacity of, and the demand on, water resources. The resulting changes include increasing climate variability that is expected to affect hydrologic conditions. The effects of climate variability on various meteorological variables have been extensively observed in many regions around the world. Atmospheric circulation, topography, land use and other regional features modify global changes to produce unique patterns of change at the regional scale. As the future changes to these water resources cannot be measured in the present, hydrological models are critical in the planning required to adapt our water resource management strategies to future climate conditions. Such models include catchment runoff models, reservoir management models, flood prediction models, groundwater recharge and flow models, and crop water balance models. In water-scarce regions such as Australia, urban water systems are particularly vulnerable to rapid population growth and climate change. In the presence of climate change induced uncertainty, urban water systems need to be more resilient and multi-sourced. Decreasing volumetric rainfall trends have an effect on reservoir yield and operation practices. Severe intensity rainfall events can cause failure of drainage system capacity and subsequent urban flood inundation problems. Policy makers, end users and leading researchers need to work together to develop a consistent approach to interpreting the effects of climate variability and change on water resources. This Special Edition includes papers by international experts who have investigated climate change impacts on a variety of systems including irrigation and water markets, land use changes and vegetation growth, lake water levels and quality and sea level rises. These investigations have been conducted in many regions of the world including the USA, China, East Africa, Australia, Taiwan and the Sultanate of Oman.
    Keywords: GE1-350 ; G1-922 ; meteorological variables ; water resources management ; uncertainty ; hydrological models ; climate models ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCN Environmental economics
    Language: English
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  • 4
    Publication Date: 2024-04-08
    Description: This book provides a coherent and conceptual portrayal of aspects of the theological research theme, entitled Ecodomy (literally meaning to ‘build a house’). In its figurative meaning the term Ecodomy addresses the theme, ‘life in its fullness’. This fullness of life entails a polarity which is inherently part of life, namely its brokenness and its wholeness. From various theological disciplines, namely Old Testament Studies, New Testament Studies, Systematic Theology, Church History and Practical Theology, both the brokenness and wholeness are addressed theologically. Every chapter focuses on a specific theological discipline, while the combination of theological disciplines, addresses the brokenness and wholeness of life as coherent concept. One pole does not exclude the other. Brokenness is visible in current or recent very relevant societal challenges, such as racism and xenophobia, apartheid, foreignness and exclusivism, leadership crises and violence. In contrast, wholeness is embedded in themes such as the African concept of ubuntu, a life of faith and wisdom, reconciling leadership, or transforming space and community. Ultimately, a Greek term ἀναίδεια (persistence) is connected to the meaning of Ecodomy and ‘life in its fullness’. Several methodologies have been used in the different contributions of the book. Every theological discipline applies a different methodology for the purpose of exposing a specific topic or research theme. In general, the contributions in this book follow a combination of a literature study with the further application of diachronic and synchronic exegetical methods. In addition, single contributions follow an own hermeneutical approach. Not one single contribution, but a combination of different theological disciplines, which form the concepts of brokenness and wholeness (life in its fullness), which expose the polarity of life, are included in this book. In its exposed interdisciplinary interwovenness, the book provides a tapestry of how different theological disciplines are combined into a single theme and how they contribute together by means of theological analyses and attempted building blocks to build the broken ‘houses’ of societal structures or human life. The book contributes to selected aspects of broken life in society and the healing experiences of human life. Several themes touch on recent and relevant challenges which have contributed to the brokenness of life. Not only in South Africa, but globally these are currently relevant themes. They include realities of racism and xenophobia, apartheid, foreignness and exclusivism, leadership crises and violence. With the focus on wholeness, specific attention is given to the African concept of ubuntu, a life of faith and wisdom, reconciling leadership, and transforming space and society. A Greek term ἀναίδεια (insolence as ‘in keeping on asking’ – Lk 11:8) illuminates the theme of Ecodomy from the perspective of a parable. The target audience of the book is academic scholars and theologians, who specialise in the different fields of Theology, the Humanities and other Social Sciences. Furthermore, the book is also accessible to scholars of other academic disciplines outside these disciplines. The book contains original research and contributions have not been plagiarised from publications elsewhere.
    Keywords: desmond tutu ; dietrich bonhoeffer ; apartheid ; beyers naudé ; ubuntu ; university of pretoria ; yhwh ; xenophobia ; south africa ; book of ruth ; God in Christianity ; Racism ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs
    Language: English
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  • 5
    Publication Date: 2024-04-06
    Description: This book’s research is on online pedagogical approaches devised by teacher educators and researchers to circumvent a face-to-face curriculum delivery during the COVID-19 pandemic. The challenge faced by educators was that they were uncertain of how to use digital technologies in teaching, learning and assessment productively. This book reports on case studies on teaching student teachers with technology in a way that advanced not only communication but also the cognitive growth of students in relation to disciplinary knowledge. The scholars from South African universities used both conceptual and empirical methodologies, mostly in qualitative set-ups. The scholarly contributions in this book are varied. They cover theoretical nuances for ICT use in education, considerations for the use of computers in the classroom, pedagogical thinking and pedagogical integration of ICTs in education, affordances of iPads in visible teaching and learning, supporting student cognition in Languages, Mathematics, Science, Engineering Graphics and Design with ICTs. The use of software applications such as GeoGebra and Excel in teaching and learning mathematics is researched, among others. The rich discussions that emerged from their research enable academics to learn from ‘others’ innovative moments that came as a result of pandemic pressure. The recommendations in this book can be used in blended learning beyond the COVID-19 era, as curriculum delivery methods are bound to change. The value of this book is that it reports on pedagogical innovations in using digital technologies in teacher education. Researchers have an opportunity to learn from this book how to deal with the tantalising teaching and learning problem of our time: How can the use of digital technology transform teaching and learning in general and teacher education in particular?
    Keywords: Teacher education ; digital technologies ; online learning ; sub-Saharan Africa ; professional development ; engage ; explore ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: English
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: The terrorist attacks on the World Trade Center towers on September 11, 2001, also referred as 9/11, was an iconic event in US history that altered the global and political response to terrorism. The attacks, which involved two planes hitting the twin towers in Lower Manhattan, New York City, resulted in the collapse of the buildings and over 2800 deaths of occupants of the buildings, fire, police and other responders and persons on the street in the vicinity of the collapsing buildings. The destroyed towers and the surrounding buildings have since been replaced but the health effects that resulted from the release of tons of dust, gases and debris as well as the life threat trauma are ongoing, and represent a major health burden among persons directly exposed. Hundreds of scientific publications have documented the physical and mental health effects attributed to the disaster. The current state-of-the-art in understanding the ongoing interactions of physical and mental health, especially PTSD, and the unique mechanisms by which pollutants from the building collapse, have resulted in long term pulmonary dysfunction, course of previously reported conditions, potential emerging conditions (e.g., heart disease and autoimmune diseases), as well as quality of life, functioning and unmet health care needs would be in the purview of this Special Issue on the 9/11 Disaster.
    Keywords: B1-5802 ; n/a ; asthma outcomes ; health insurance ; mental health ; handgrip strength ; WTC ; cognitive reserve ; disaster epidemiology ; surveillance bias ; cardiac sarcoidosis ; lung function ; lung injury ; treatment utilization ; injury ; Cox regression ; lower Manhattan residents ; chronic sinusitis ; social support ; indoor allergens sensitization ; respiratory function ; FDNY ; asthma control ; sarcoidosis ; asthma ; 9/11 impact ; physical health ; rescue/recovery workers ; chronic disease ; evidence-based treatment ; irritant(s) ; fibrosis ; unmet mental health care needs ; airway hyperreactivity ; asthma quality of life ; Short Form-12 (SF-12) ; WTC-related asthma ; longitudinal analysis ; forced oscillation ; thyroid cancer ; psychotherapy ; cognitive decline ; 9/11 disaster ; severe lung disease ; prevalence ; inflammation ; pulmonary function tests ; World Trade Center disaster ; disaster mental health ; epidemiological studies ; obstructive sleep apnea ; counseling ; sleepiness ; PTSD ; hazard function ; cleaning practices ; air pollution ; aging ; stressful life events ; airway physiology ; screening ; PTSD cluster ; latent class analysis ; retirement ; environmental health ; World Trade Center ; quality improvement ; pulmonary fibrosis ; WTC attack ; dust ; PCL score ; WTC responders ; mini asthma quality of life questionnaire ; biomarkers ; HQoL ; health-related quality of life ; Scadding stage ; 9/11 ; firefighters ; allergen exposure ; metabolic syndrome ; neuropathic symptoms ; small airway disease ; Asian Americans ; asthma morbidity ; PTSD symptom change ; WTC survivors ; trigger(s) ; World Trade Center exposure ; occupational exposure ; peripheral neuropathy ; disaster ; respiratory symptoms ; mental health treatment ; genetics ; mental health service utilization ; comorbid insomnia ; sleep-related quality of life ; World Trade Center attack ; immunoglobulin E ; mental health service use ; income loss ; paresthesia ; World Trade Center (WTC) ; fibrotic sarcoid ; depression ; post-disaster ; mental health conditions ; extrathoracic sarcoidosis ; medical imaging ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: English
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-01
    Description: Canadian Pharmaceutical Scientists have a rich history of ground-breaking research in pharmacokinetics and drug metabolism undertaken throughout its Pharmacy and Medical Schools and within the Pharmaceutical and biotechnology industry. The principle of drug Absorption, Distribution, Metabolism and Excretion (ADME) is the foundational basis of rationale drug-design, and pharmacotherapy. The study of ADME and its descriptive quantitative analysis is the basis of pharmacokinetics. Pharmacokinetics is fundamental in the development of a new chemical entity into a marketable product and is essential in understanding the bioavailability, bioequivalence and biosimilarities of drugs. Pharmacokinetics and drug development studies facilitate an understanding of organ-based functionality. Population pharmacokinetic variability and the modeling of drug concentrations has significant utility in translating individual response in a target patient population. This special issue serves to highlight and capture the contemporary progress and current landscape of pharmacokinetics and drug metabolism within the prevailing Canadian context. We invite articles on all aspects of Pharmacokinetics and Drug Metabolism studies highlighting the world-class research currently undertaken in Canada for this special issue.
    Keywords: RM1-950 ; Pharmaceutical Sciences ; Canada ; Drug Metabolism ; Pharmacology ; Drug Delivery ; Pharmacokinetics ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 8
    Publication Date: 2022-06-22
    Description: This publication deals with A Biblical Theology of Life based on the New Testament. It forms the second of a two volume publication on A Biblical Theology of Life. These two volumes trace the concept of life throughout Protestant canon, working with the final form of the biblical books in Hebrew (vol. 5) and Greek (vol. 6) Scripture. This is done by providing the reader with a book-by-book overview of this concept. This book concludes with a final chapter synthesising the findings of the respective investigations of the Old and New Testament corpora in order to provide a summative theological perspective of the development of the concept through Scripture. It is clear that life forms a central and continuous theme throughout the Biblical text. The theme begins with the living God that creates life, but is shortly followed by death that threatens life. Despite this threat, God sustains life and awakens life from death. The text concludes with the consummation depicting eternal life in the new heaven and earth. The biblical theological approach that has been taken entails a thematic approach as it investigates the concept of life, with contextual foci on what individual books of Scripture teach about life, joined diachronically with an investigation of the progressive use of the concept of life in Scripture, while providing a theology of Scripture as a whole investigating the concept of life in all sixty-six books of the Protestant canon.
    Keywords: Biblical theology ; life ; living ; New Testament ; history of revelation ; eschaton ; sustainance
    Language: English
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  • 9
    Publication Date: 2024-04-01
    Description: The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed. Clearly, it is not possible to capture the entire literature in a single thematic issue. Consequently, the selection of articles presented in this book represents a sampling of the literature, and is admittedly subjective. We tried to survey the wide range of human diseases in which TRP channels have been implicated, ranging from chronic pain through asthma and diabetes to cancer, and highlight the channels that appear to hold the greatest promise for therapeutic targeting. With this book, we hope to convince readers that TRP channels constitute a formidable family of potential therapeutic targets that will likely continue to demand attention.
    Keywords: RM1-950 ; resiniferatoxin ; pain ; TRPA1 ; TRPV3 ; TRPV1 ; TRP channels ; TRPM2 ; respiratory disorders ; permanent analgesia ; capsaicin ; TRPM7 ; cancer ; TRPM8 ; diabetes ; obesity ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
    Keywords: QH301-705.5 ; Q1-390 ; HCP5 ; n/a ; camels ; MHC ; STK19 ; major histocompatibility complex ; human papillomavirus (HPV) ; T-cell receptor ; T1DGC ; bottleneck ; micro-mini-pigs ; life history ; computational analysis ; hepatocellular carcinoma ; phase ; Bactrian camel ; NSDK ; melanoma ; antigen ; autoimmune disease ; RD ; selection ; disease resistance ; autoimmunity ; ancestral haplotype ; Ski complex ; DXO ; high-throughput sequencing ; conservation genetics ; SVA ; lncRNA ; ankylosing spondylitis ; MHC genes ; viral peptides ; competing endogenous RNA (ceRNA) ; astrogliosis ; birds ; long-fragment super haplotype ; SNP ; RLR ; HLA polymorphism ; 5??3? RNA decay ; expression ; 3??5? mRNA turnover ; orthology ; long-read sequencing ; disease association ; dromedary ; polyomavirus ; MHC-II-associated sperm-egg recognition ; experimental medicine ; single nucleotide polymorphism (SNP) ; fish ; SKIV2L ; production trait ; molecular dynamics simulation ; Macaca fascicularis ; human endogenous retrovirus (HERV) ; concerted evolution ; polymorphism ; Old World camels ; MHC polymorphism ; protocol ; nonclassical ; gene duplication ; microglial reaction ; human leukocyte antigen-E ; SKI2W ; quantitative trait loci (QTL) studies ; antiviral immunity ; human immunodeficiency virus (HIV) ; founder effect ; giant panda ; domain movements ; BK virus ; promoter-proximal transcriptional pause ; type 1 diabetes (T1D) ; RP1 ; miR1236 ; KIR ; synaptic covering ; swine leukocyte antigen ; cynomolgus macaque ; HLA ; kidney transplantation ; ?2m knockout mice ; DOM3Z ; interferon ? ; ethnic populations in China ; ecology ; KIR–HLA pairs ; exosomes ; major histocompatibility complex (MHC) ; MHC-I-based mother-fetus recognition ; RNA quality control ; autoimmune diseases ; NELF-E ; haplotype ; genetic drift ; evolution ; nonhuman primate models ; HLA-B27 ; PNS/CNS interface ; risk genes ; pedigree ; MHC-I- and MHC-II-dependent inter-individual recognition ; regulation ; crested ibis ; reproductive performance ; nephropathy ; cancer ; nuclear kinase ; trichohepatoenteric syndrome ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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