ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    EVIDENCE THAT DERIVATION OF THE ADENOCARCINOMA LT85 PREDATED ESTABLISHMENT OF THE H-2km2 MUTATION IN A C3HF COLONY OF MICE (1989)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 16 (1989), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The adenocarcinoma LT85 was chemically induced in a mouse from a C3Hf colony shown subsequently to be inbred for a gene conversion-like mutation at the H-2K locus, characterized by a clustered four nucleotide substitution in exon 3. The H-2K phenotype of LT85, however, more closely resembles that of C3H rather than the mutant strain now designated C3Hf H-2km2. We cloned and sequenced the H-2K gene from this tumor to determine whether (i) LT85 might carry a tumor-associated somatic reversion of the H-2Kkm2 germline mutation or (ii) the tumor was induced in a mouse that was genetically H-2k rather than H-2km2. Our analysis confirmed that the LT85 H-2K allele is identical throughout the entire coding region to C3H H-2Kk. To exclude the possibility of a somatic reversion by recombination, we used an oligonucleotide probe corresponding to the region altered in H-2k to show that the C3Hf genome lacks the necessary coding information to reverse the H-2Kkm2 mutation through a sequence exchange with another class I locus. Since it is unlikely that multiple independent point mutations would account for restoration of this stretch of H-2Kk sequences, the tumor was probably established in a mouse carrying a normal H-2Kk allele, possibly at a point prior to the establishment of the H-2Kkm2 mutation as a homozygous trait within the C3Hf colony.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1989.tb00483.x
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    When should bone density measurements be repeated? (1994)
    Springer
    Calcified tissue international 55 (1994), S. 243-248 
    Details
    ISSN: 1432-0827
    Keywords: Osteoporosis ; Bone density ; Longitudinal studies ; Statistical models ; Decision models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract We calculated how long to wait before repeating bone mineral density (BMD) measurements to reassess fracture risk. Correlation results from serial measurements of 495 postmenopausal Japanese-American women were used to estimate 95% confidence intervals (CI) for future BMD. After 7 years of follow-up, BMD correlations with the initial measurement ranged between 0.81 and 0.94, depending on age group and measurement site. In this analysis, the period between measurements was defined as the time required for the lower 95% CI to fall below the BMD value corresponding to doubling of fracture risk. Progressive bone loss causes fracture risk to double after 10 years, on average. However, the 95% CIs indicate that a second BMD measurement will detect risk doubling after only 2 or 3 years for some women. For untreated, early postmenopausal women, the period between measurements was approximately 2–5 years for the radius and 4–6 years for the calcaneus, depending on the initial BMD level. The period was approximately 1 year longer for women age 60 and older. Treatments that halve the bone loss rate would increase the period by 1–3 years. In the absence of a second measurement of BMD, the CI will continue to expand with time, corresponding to a wider range in risk between individuals, and a greater proportion of women will be at increased fracture risk. Obtaining a second BMD measurement pinpoints the patient's status within the precision of the measurement. We conclude that repeated BMD measurements will provide a more accurate estimate of fracture risk than a single, baseline measurement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310399
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    facet.materialart.
    Unknown
    Bone mineral measurement: Experiment M078 (1977)
    In:  CASI
    Details
    Publication Date: 2006-01-16
    Description: Gamma ray absorptiometric measurements on bone mineral content, in addition to calcium balance studies, were performed on male volunteers during bed rest periods of 24 to 36 weeks duration and compared to Skylab mission data. Results show that mineral losses occur from the bones of the lower extremities during missions of up to 84 days and that in general they follow the loss patterns of the bed rest situation. The level of loss observed in Spacelab crews are not of clinical concern.
    Keywords: AEROSPACE MEDICINE
    Type: Biomed. Results from Skylab; p 183-190
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 4
    facet.materialart.
    Unknown
    Skeletal response (1975)
    In:  CASI
    Details
    Publication Date: 2006-01-12
    Description: The effect of weightlessness on bone mineral content during prolonged space flight was investigated. The mineral content changes which occurred during Apollo 14, 15, and 16 as measured by photon absorptiometry techniques are presented and compared. Bed rest served as an experimental model to assess the bone mineral changes, and to determine what remedial measures might be used to stem the tide of bone mineral loss. It is concluded that loss of mineral from bone due to the state of weightlessness is comparable to that observed in bed rest subjects.
    Keywords: AEROSPACE MEDICINE
    Type: Biomedical Results of Apollo; p 303-322
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 5
    facet.materialart.
    Unknown
    Bone mineral measurement, experiment M078 (1973)
    In:  CASI
    Details
    Publication Date: 2006-01-11
    Description: Measurement tests revealed few deviations from baseline bone mineral measurements after 56 days in a Skylab-type environment. No mineral change was observed in the right radius. One individual, however, showed a possible mineral loss in the left os calcis and another gained mineral in the right ulna. The cause of the gain is unclear but may be attributable to the heavy exercise routines engaged in by the crewmember in question. Equipment problems were identified during the experiment and rectified.
    Keywords: BIOSCIENCES
    Type: Skylab Med. Expt. Altitude Test (SMEAT); 6 p
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 6
    facet.materialart.
    Unknown
    Effect of potassium depletion in normal males - An Apollo 15 simulation (1975)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: In the course of Apollo 15, physiologic abnormalities, manifested by ectopic activity on the ECG and unusual alterations in exercise tolerance, occurred in the crew of the Lunar Excursion Module. These were associated with decreases in total body potassium, measured by K-42, of 10% and 15%. The possibility of inadequate potassium (K+) intake existed. A simulation study was performed prior to Apollo 16, corresponding in duration to Apollo 15. Subjects endured the same sleep aberrations and caloric expenditure as the Apollo 15 astronauts. Subjects consumed a diet containing only 15 mEq/d of K+ during the entire 12 days of absolute bedrest. Study implications and reasons for discrepancies between K+ loss measured by balance techniques and K-42 are reviewed.
    Keywords: AEROSPACE MEDICINE
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 7
    facet.materialart.
    Unknown
    Bone mineral changes - The second manned Skylab mission (1976)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: The mineral content of the central os calcis, and distal radius and ulna was measured by the monoenergetic photon absorptiometric technique pre- and postflight on the SL-3 crewmen. No significant changes were observed in the radius and ulna. Only the SPT showed a loss in calcaneal mineral which slowly returned to preflight levels by the 87th postflight day.
    Keywords: AEROSPACE MEDICINE
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 8
    facet.materialart.
    Unknown
    Vortex sheet modeling with curved higher-order panels (1987)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Keywords: AERODYNAMICS
    Type: Journal of Aircraft (ISSN 0021-8669); 24; 776-782
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 9
    facet.materialart.
    Unknown
    Wing/body interference flow investigation (1986)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: The concept of using parametric bicubic patch surface definitions with bilinear vorticity or biquadratic doublet distributions was tested by modeling the vortex sheet and predicting its shape numerically in the vicinity of the wing. For the purpose of computing induced velocities, it was shown that higher order of vorticity would not improve the truncation error. The bilinear distribution, used to model the tip vorticity, was satisfactory but gave rise to some difficulty. The bicubic geometric surface representation proved very suitable for curved surfaces such as the rolled-up vortex sheet, with the surface fit scheme failing only for complex wings, far downstream beyond the region of concern.
    Keywords: AERODYNAMICS
    Type: NASA-CR-179979 , NAS 1.26:179979
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
  • 10
    facet.materialart.
    Unknown
    The use of curved higher order panels for vortex sheet modeling (1986)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: A method is presented for predicting the geometry of a vortex sheet trailing a lift generating wing in its vicinity. It differs from others in that it uses a continuous vorticity distribution rather than discrete vortex filaments. It was found that the results were in good agreement with available experimental data, after the initial cycle of what was to be a relaxation scheme, so that iterations for this end were unnecessary. While the technique is computing intensive, it becomes attractive when used in conjunction with panel methods applications for complete aircraft configurations. The panel method solution needs to be found only once for each streamwise station downstream of the wing. Corrections applied are geometric in nature and are independent of other computational aspects.
    Keywords: AERODYNAMICS
    Type: AIAA PAPER 86-1812
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    NASA TECHNICAL REPORTS
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...