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  • 1
    Online Resource
    Online Resource
    Cardiovascular Neuroendocrinology (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurophysiology. ; Neurons. ; Cardiovascular system. ; Physiology. ; Cardiology. ; Endocrinology. ; Cellular Neuroscience. ; Cardiovascular Physiology. ; Cardiology. ; Endocrinology.
    Description / Table of Contents: Part I. Neuroendocrine Systems and Cardiovascular Function -- Chapter 1. Neural Control of Cardiovascular Function: Role of Osmosensation -- Chapter 2. Central Neuroendocrine Control of the Cardiovascular System -- Chapter 3. Neuroendocrine Control of the Vascular System -- Chapter 4. Sex Differences in Vascular Function -- Part II. Neuroendocrinology of Cardiovascular Dysfunction and Aging -- Chapter 5. Cardiovascular Neuroendocrinology of Pregnancy -- Chapter 6. Cerebrovascular Function in Aging -- Chapter 7. Cardiovascular Responses to Exercise in Diabetes -- Chapter 8. Interactions of Stress, Psychology, and Cardiovascular Function -- Chapter 9. Neuroendocrinology Therapeutic Pathways for Cardiovascular Disease.
    Abstract: The cardiovascular system and the neuroendocrine system are integrated at multiple levels. This integration is key to normal physiological function. Further, it adapts to accommodate changes related to aging, the organism’s reproductive state, or physiological challenges. This type of adaptability, or plasticity, also can contribute to pathophysiology when these systems are stressed. This volume discusses how neuroendocrine systems influence cardiovascular function in health and disease. The first section provides detailed background information on neuronal and neuroendocrine control of cardiovascular function. This is followed by chapters highlighting the cardiovascular role of neuroendocrine hormones in regulating physiological states, such as pregnancy, and the effects of biological sex on vascular function. The influence of exercise, stress, psychology, and aging on cardiovascular function and dysfunction, and the possibility of therapeutically targeting the neuroendocrine axis for the treatment of cardiovascular disease are discussed in the final section of the book. This book is of relevance for students, trainees and established researchers alike who are seeking for an overview on the neuroendocrine control of cardiovascular function and disease. This is the fourteenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.
    Type of Medium: Online Resource
    Pages: IX, 238 p. 27 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031399954
    Series Statement: Masterclass in Neuroendocrinology, 14
    URL: https://doi.org/10.1007/978-3-031-39995-4
    DOI: 10.1007/978-3-031-39995-4
    DDC: 612.81046
    Language: English
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    E-BOOKS (AWI ONLY)
  • 2
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    Investigation of rising nitrate concentrations in groundwater in the Eden Valley, Cumbria: Phase 1 project scoping study (2021)
    Environment Agency | UK
    In:  dis@fba.org.uk | http://aquaticcommons.org/id/eprint/10969 | 1256 | 2013-03-26 13:54:54 | 10969 | Environment Agency, UK (Freshwater Biological Association)
    Details
    Publication Date: 2021-06-25
    Description: This is the Investigation of rising nitrate concentrations in groundwater in the Eden Valley, Cumbria report produced by the Environment Agency in 2003. This report focuses on groundwater nitrate concentrations in the Eden Valley. Most boreholes in the Eden Valley had nitrate concentrations less than 20 mg/l but a significant number had higher concentrations, some exceeding the EC maximum admissible concentration for drinking water of 50 mg/l. The main objectives of this report were to investigate the causes of rising nitrate concentrations in groundwater in the Permo-Triassic sandstone aquifers of the Eden Valley area and provide sufficient understanding of the groundwater and surface water flow system, including the sources of the nitrate contamination and the processes controlling nitrate movement, so that possible management options for reversing this trend can be considered.
    Description: Environment Agency Archives North West
    Keywords: Fisheries ; Limnology ; Management ; England ; Cumbria ; Eden valley ; Rivers ; Aquifers ; Boreholes ; Freshwater pollution ; Water quality ; Nitrate concentrations ; Hydrology ; Modelling
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 86
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    PAPER (OA)
  • 3
    Electronic Resource
    Electronic Resource
    Structures of europium complexes and implications in lanthanide nuclear magnetic resonance shift reagent chemistry (1980)
    s.l. : American Chemical Society
    Inorganic chemistry 19 (1980), S. 595-604 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50205a005
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The heredity of secondary sexual characters in relation to hormones, a theory of the heredity of somatogenic characters (1908)
    Springer
    Development genes and evolution 26 (1908), S. 372-428 
    Details
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02161553
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Urinary D-glucaric acid excretion and acetanilide pharmacokinetics before and during diphenylhydantoin administration (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 387-391 
    Details
    ISSN: 1432-1041
    Keywords: Acetanilide ; diphenylhydantoin ; D-glucaric acid ; induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of a single-dose acetanilide (AA) test, and the urinary D-glucaric acid output (UDGAO) were studied in healthy drug free volunteer subjects before and at the end of a fourteen-day period of medication with 5 mg diphenylhydantoin sodium (DPH) per kg metabolically active mass, thrice daily. The steady state plasma concentration (SSPC) of DPH was also determined. The SSPC of DPH was found to vary from 3.4 to 19.6 µg per ml. The mean UDGAO values increased significantly during DPH medication from 9.5 µmol per g creatinine to 29.5 (p〈0.002). The half-life of plasma AA concentration decreased significantly during DPH medication from a mean of 4.2 h to a mean of 2.8 (p〈0.001). However, the plasma clearance of AA did not change significantly during DPH medication. The increase of UDGAO whilst on treatment with DPH correlated positively with the SSPC of DPH. The evidence from this study suggests that measurement of UDGAO, which is a measure of the activity of the glucuronic pathway does not necessarily indicate the state of induction of oxidizing enzymes in the hepatic endoplasmic reticulum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558212
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  • 6
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of acetanilide and of diphenylhydantoin sodium (1974)
    Springer
    European journal of clinical pharmacology 7 (1974), S. 461-466 
    Details
    ISSN: 1432-1041
    Keywords: Acetanilide ; oxidation ; diphenylhydantoin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Acetanilide and diphenylhydantoin have a similar first stage biotransformation in that both are oxidized in the para position of the benzene ring incorporated in each of the two molecules. The elimination of acetanilide from the plasma was studied in thirty healthy volunteer subjects following a single oral dose of 50 mg per kg metabolically active mass (MAM = weight to the power of 0.7). Plasma clearance values varied from 12.4 to 25.11 per hour. A dose of 5 mg diphenylhydantoin sodium (DPH) per kg MAM was then given thrice daily for 13 days to the same volunteers. The steady state plasma concentrations of DPH varied from 3.4 to 19.6 µg per ml. Statistically significant correlation was demonstrated between plasma acetanilide clearance and DPH clearance (r=+0.4984). This finding suggests either a common enzyme acceptor or a common rate-limiting step in the metabolism of the two drugs. It is possible that the pharmacokinetics of other widely used drugs known to be oxidized, especially phenylbutazone, may also be correlated with the kinetics of acetanilide and of DPH. If this were so, then certain individuals might be at a relatively high risk (due to drug accumulation) of developing adverse effects from drugs metabolized mainly by oxidation, and certain other individuals who metabolize these compounds at a fast rate are likely not to derive therapeutic benefit. A single dose study with simple measurement of acetanilide pharmacokinetics could be used to identify these groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00560359
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  • 7
    Electronic Resource
    Electronic Resource
    Radiation Damage of Silicon and Diamond by High Energy Neutrons, Protons and α Particles (1997)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 258-263 (Dec. 1997), p. 787-792 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/03/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.258-263.787.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Differential fructose effect in Pachysolen tannophilus and Pichia stipitis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 57 (1989), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract The yeasts Pachysolen tannophilus and Pichia stipitis differed in their ability to utilize d-xylose in the presence of d-fructose. When P. tannophilus was grown aerobically in a fructose-xylose mixture, the ketohexose was utilized preferentially over the pentose. However, in P. stipitis cultures, the converse was observed. The effect was associated with the ability of d-fructose to repress the induction of xylose reductase and xylitol dehydrogenase activities in P. tannophilus but not in P. stipitis. Both yeasts grew on d-fructose and fermented it to ethanol when it was supplied as the sole carbon source. The results suggest that there may exist some fundamental difference in the regulation of d-fructose metabolism between P. tannophilus and P. stipitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1989.tb03357.x
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  • 9
    Electronic Resource
    Electronic Resource
    A cybernetic framework linking personality and other variables in understanding general health (2004)
    Bingley : Emerald
    Personnel review 33 (2004), S. 55-80 
    Details
    ISSN: 0048-3486
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Personality traits such as anxiety, self-esteem and aggressive hostility are often thought to affect the stress that a person perceives or manifests. With data from 176 male executives, this study suggests that there are indirect and interacting relationships between personality and general health. This article proposes a cybernetic framework that links personality with other variables in understanding overall health. The framework specifies that personal characteristics (i.e. age), personality, and environment all play a role, each interacting systemically. The framework provides a basis for illustrating these interactions. For example, while type A personalities are more likely to get involved in more stressful situations, their negative health effects might depend on other variables, such as self-esteem and years in the job. While personality features are important risk factors, they may not, by themselves, predict stress. Stress is the result of interacting variables including age, position, job level, the stress experience, and one's personality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/00483480410510624
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  • 10
    Electronic Resource
    Electronic Resource
    Designing flexible logistics systems: a review of some Singaporean examples (1996)
    Bradford : Emerald
    Logistics information management 9 (1996), S. 40-48 
    Details
    ISSN: 0957-6053
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: The increased efficiencies to be gained in improving logistics has pushed managers to explore a number of new ideas, technologies, and methods of information management and computerization. However, many companies in Asia are indicating that responsiveness and flexibility are the keys to responding to markets which are rapidly changing and where customers are requiring a range of services. Studies several local and international logistics firms in Singapore and elsewhere as a way of developing a better understanding of their difficulties and reasons for success. Illustrates why certain larger companies which have the capability to develop more sophisticated information and computer systems do not; instead, they chose to rely on more flexible systems which allow for learning and adaptation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09576059610113296
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