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  • 1
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    Tetramers reveal U1-70-specific CD4+ T cells [Immunology and Inflammation] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-03-11
    Description: Antigen-specific CD4+ T cells are implicated in the autoimmune disease systemic lupus erythematosus (SLE), but little is known about the peptide antigens that they recognize and their precise function in disease. We generated a series of MHC class II tetramers of I-Ek–containing peptides from the spliceosomal protein U1-70 that specifically...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Feasibility of graphene CRLH metamaterial waveguides and leaky wave antennas (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-07-07
    Description: The feasibility of composite right/left-handed (CRLH) metamaterial waveguides based upon graphene plasmons is demonstrated via numerical simulation. Designs are presented that operate in the terahertz frequency range along with their various dimensions. Dispersion relations, radiative and free-carrier losses, and free-carrier based tunability are characterized. Finally, the radiative characteristics are evaluated, along with its feasibility for use as a leaky-wave antenna. While CRLH waveguides are feasible in the terahertz range, their ultimate utility will require precise nanofabrication, and excellent quality graphene to mitigate free-carrier losses.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 3
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    Efficacy of 670 nm Light Therapy to Protect against Photoreceptor Cell Death Is Dependent on the Severity of Damage (2016)
    Hindawi
    Details
    Publication Date: 2016-02-29
    Description: Photobiomodulation at a wavelength of 670 nm has been shown to be effective in preventing photoreceptor cell death in the retina. We treated Sprague-Dawley (SD) rats with varying doses of 670 nm light (9; 18; 36; 90 J/cm2) before exposing them to different intensities of damaging white light (750; 1000; 1500 lux). 670 nm light exhibited a biphasic response in its amelioration of cell death in light-induced degeneration in vivo. Lower light damage intensities required lower doses of 670 nm light to reduce TUNEL cell death. At higher damage intensities, the highest dose of 670 nm light showed protection. In vitro, the Seahorse XFe96 Extracellular Flux Analyzer revealed that 670 nm light directly influences mitochondrial metabolism by increasing the spare respiratory capacity of mitochondria in 661 W photoreceptor-like cells in light damaged conditions. Our findings further support the use of 670 nm light as an effective treatment against retinal degeneration as well as shedding light on the mechanism of protection through the increase of the mitochondrial spare respiratory capacity.
    Print ISSN: 1110-662X
    Electronic ISSN: 1687-529X
    Topics: Electrical Engineering, Measurement and Control Technology , Energy, Environment Protection, Nuclear Power Engineering
    Published by Hindawi
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  • 4
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    Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice (2013)
    Oxford University Press
    Details
    Publication Date: 2013-12-11
    Description: Recent human genetic studies have provided evidences that sporadic or inherited missense mutations in four-and-a-half LIM domain protein 1 (FHL1), resulting in alterations in FHL1 protein expression, are associated with rare congenital myopathies, including reducing body myopathy and Emery–Dreifuss muscular dystrophy. However, it remains to be clarified whether mutations in FHL1 cause skeletal muscle remodeling owing to gain- or loss of FHL1 function. In this study, we used FHL1-null mice lacking global FHL1 expression to evaluate loss-of-function effects on skeletal muscle homeostasis. Histological and functional analyses of soleus, tibialis anterior and sternohyoideus muscles demonstrated that FHL1-null mice develop an age-dependent myopathy associated with myofibrillar and intermyofibrillar (mitochondrial and sarcoplasmic reticulum) disorganization, impaired muscle oxidative capacity and increased autophagic activity. A longitudinal study established decreased survival rates in FHL1-null mice, associated with age-dependent impairment of muscle contractile function and a significantly lower exercise capacity. Analysis of primary myoblasts isolated from FHL1-null muscles demonstrated early muscle fiber differentiation and maturation defects, which could be rescued by re-expression of the FHL1A isoform, highlighting that FHL1A is necessary for proper muscle fiber differentiation and maturation in vitro . Overall, our data show that loss of FHL1 function leads to myopathy in vivo and suggest that loss of function of FHL1 may be one of the mechanisms underlying muscle dystrophy in patients with FHL1 mutations.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 5
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    Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease [Medical Sciences] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-09-28
    Description: Insulin resistance is associated with nonalcoholic fatty liver disease (NAFLD) and is a major factor in the pathogenesis of type 2 diabetes. The development of hepatic insulin resistance has been ascribed to multiple causes, including inflammation, endoplasmic reticulum (ER) stress, and accumulation of hepatocellular lipids in animal models of NAFLD. However, it is unknown whether these same cellular mechanisms link insulin resistance to hepatic steatosis in humans. To examine the cellular mechanisms that link hepatic steatosis to insulin resistance, we comprehensively assessed each of these pathways by using flash-frozen liver biopsies obtained from 37 obese, nondiabetic individuals and correlating key hepatic and plasma markers of inflammation, ER stress, and lipids with the homeostatic model assessment of insulin resistance index. We found that hepatic diacylglycerol (DAG) content in cytoplasmic lipid droplets was the best predictor of insulin resistance (R = 0.80, P 〈 0.001), and it was responsible for 64% of the variability in insulin sensitivity. Hepatic DAG content was also strongly correlated with activation of hepatic PKCε (R = 0.67, P 〈 0.001), which impairs insulin signaling. In contrast, there was no significant association between insulin resistance and other putative lipid metabolites or plasma or hepatic markers of inflammation. ER stress markers were only partly correlated with insulin resistance. In conclusion, these data show that hepatic DAG content in lipid droplets is the best predictor of insulin resistance in humans, and they support the hypothesis that NAFLD-associated hepatic insulin resistance is caused by an increase in hepatic DAG content, which results in activation of PKCε.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 6
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    The double galaxy cluster Abell 2465 - II. Star formation in the cluster (2014)
    Oxford University Press
    Details
    Publication Date: 2014-12-21
    Description: We investigate the star formation rate and its location in the major merger cluster Abell 2465 at z  = 0.245. Optical properties of the cluster are described in Paper I . Measurements of the Hα and infrared dust emission of galaxies in the cluster were made with an interference filter centred on the redshifted line at a wavelength of 817 nm and utilized data from the Wide-field Infrared Survey Explorer satellite 12 μm band. Imaging in the Johnson U and B bands was obtained, and along with Sloan Digital Sky Survey u and r was used to study the blue fraction, which appears enhanced, as a further signature of star formation in the cluster. Star formation rates were calculated using standard calibrations. The total star formation rate normalized by the cluster mass, SFR/ M cl compared to compilations for other clusters indicate that the components of Abell 2465 lie above the mean z and M cl relations, suggestive that interacting galaxy clusters have enhanced star formation. The projected radial distribution of the star-forming galaxies does not follow an NFW profile and is relatively flat indicating that fewer star-forming galaxies are in the cluster centre. The morphologies of the Hα sources within R 200 for the cluster as a whole indicate that many are disturbed or merging, suggesting that a combination of merging or harassment is working.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 7
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    On the diffuse X-ray emission from the Wolf-Rayet bubble NGC 2359 (2014)
    Oxford University Press
    Details
    Publication Date: 2014-11-18
    Description: A recent XMM–Newton observation has revealed diffuse X-ray emission inside the nebula NGC 2359 around the Wolf–Rayet star WR 7. Taking advantage of an improved point-source rejection and background subtraction, and a detailed comparison of optical and X-ray morphology, we have reanalysed these X-ray observations. Our analysis reveals diffuse X-ray emission from a blowout and the presence of emission at energies from 1.0 to 2.0 keV. The X-ray emission from NGC 2359 can be described by an optically thin plasma emission model, but contrary to previous analysis, we find that the chemical abundances of this plasma are similar to those of the optical nebula, with no magnesium enhancement, and that two components at temperatures T 1  = 2 10 6  K and T 2  = 5.7 10 7  K are required. The estimated X-ray luminosity in the 0.3–2.0 keV energy range is L X  = 2 10 33  erg s –1 . The averaged rms electron density of the X-ray-emitting gas ( n e   0.6 cm –3 ) reinforces the idea of mixing of material from the outer nebula into the hot bubble.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 8
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    The double galaxy cluster Abell 2465 - II. Star formation in the cluster (2014)
    Oxford University Press
    Details
    Publication Date: 2014-12-29
    Description: We investigate the star formation rate and its location in the major merger cluster Abell 2465 at z  = 0.245. Optical properties of the cluster are described in Paper I . Measurements of the Hα and infrared dust emission of galaxies in the cluster were made with an interference filter centred on the redshifted line at a wavelength of 817 nm and utilized data from the Wide-field Infrared Survey Explorer satellite 12 μm band. Imaging in the Johnson U and B bands was obtained, and along with Sloan Digital Sky Survey u and r was used to study the blue fraction, which appears enhanced, as a further signature of star formation in the cluster. Star formation rates were calculated using standard calibrations. The total star formation rate normalized by the cluster mass, SFR/ M cl compared to compilations for other clusters indicate that the components of Abell 2465 lie above the mean z and M cl relations, suggestive that interacting galaxy clusters have enhanced star formation. The projected radial distribution of the star-forming galaxies does not follow an NFW profile and is relatively flat indicating that fewer star-forming galaxies are in the cluster centre. The morphologies of the Hα sources within R 200 for the cluster as a whole indicate that many are disturbed or merging, suggesting that a combination of merging or harassment is working.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 9
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    A high-resolution radiation hybrid map of the human genome draft sequence (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-22
    Description: We have constructed a physical map of the human genome by using a panel of 90 whole-genome radiation hybrids (the TNG panel) in conjunction with 40,322 sequence-tagged sites (STSs) derived from random genomic sequences as well as expressed sequences. Of 36,678 STSs on the TNG radiation hybrid map, only 3604 (9.8%) were absent from the unassembled draft sequence of the human genome. Of 20,030 STSs ordered on the TNG map as well as the assembled human genome draft sequence and the Celera assembled human genome sequence, 36% of the STSs had a discrepant order between the working draft sequence and the Celera sequence. The TNG map order was identical to one of the two sequence orders in 60% of these discrepant cases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olivier, M -- Aggarwal, A -- Allen, J -- Almendras, A A -- Bajorek, E S -- Beasley, E M -- Brady, S D -- Bushard, J M -- Bustos, V I -- Chu, A -- Chung, T R -- De Witte, A -- Denys, M E -- Dominguez, R -- Fang, N Y -- Foster, B D -- Freudenberg, R W -- Hadley, D -- Hamilton, L R -- Jeffrey, T J -- Kelly, L -- Lazzeroni, L -- Levy, M R -- Lewis, S C -- Liu, X -- Lopez, F J -- Louie, B -- Marquis, J P -- Martinez, R A -- Matsuura, M K -- Misherghi, N S -- Norton, J A -- Olshen, A -- Perkins, S M -- Perou, A J -- Piercy, C -- Piercy, M -- Qin, F -- Reif, T -- Sheppard, K -- Shokoohi, V -- Smick, G A -- Sun, W L -- Stewart, E A -- Fernando, J -- Tejeda -- Tran, N M -- Trejo, T -- Vo, N T -- Yan, S C -- Zierten, D L -- Zhao, S -- Sachidanandam, R -- Trask, B J -- Myers, R M -- Cox, D R -- R01 GM062628/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2001 Feb 16;291(5507):1298-302.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford Human Genome Center, Stanford University School of Medicine, 975 California Avenue, Palo Alto, CA 94304, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11181994" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Chromosomes, Artificial, Bacterial ; Computational Biology ; Contig Mapping ; Databases, Factual ; *Genome, Human ; Human Genome Project ; Humans ; In Situ Hybridization, Fluorescence ; Physical Chromosome Mapping ; Polymerase Chain Reaction ; *Radiation Hybrid Mapping ; *Sequence Analysis, DNA ; Sequence Tagged Sites ; Software
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Parallel neural pathways mediate CO2 avoidance responses in Drosophila (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-06-15
    Description: Different stimulus intensities elicit distinct perceptions, implying that input signals are either conveyed through an overlapping but distinct subpopulation of sensory neurons or channeled into divergent brain circuits according to intensity. In Drosophila, carbon dioxide (CO2) is detected by a single type of olfactory sensory neuron, but information is conveyed to higher brain centers through second-order projection neurons (PNs). Two distinct pathways, PN(v)-1 and PN(v)-2, are necessary and sufficient for avoidance responses to low and high CO2 concentrations, respectively. Whereas low concentrations activate PN(v)-1, high concentrations activate both PN(v)s and GABAergic PN(v)-3, which may inhibit PN(v)-1 pathway-mediated avoidance behavior. Channeling a sensory input into distinct neural pathways allows the perception of an odor to be further modulated by both stimulus intensity and context.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, Hui-Hao -- Chu, Li-An -- Fu, Tsai-Feng -- Dickson, Barry J -- Chiang, Ann-Shyn -- New York, N.Y. -- Science. 2013 Jun 14;340(6138):1338-41. doi: 10.1126/science.1236693.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23766327" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carbon Dioxide ; Drosophila melanogaster/*physiology ; Escape Reaction/*physiology ; Olfactory Pathways/*physiology ; Olfactory Receptor Neurons/cytology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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