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  • 1
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    Direct measurement of interfacial Dzyaloshinskii-Moriya interaction in X|CoFeB|MgO heterostructures with a scanning NV magnetometer (X=Ta,TaN, and W) (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-08-12
    Description: Author(s): I. Gross, L. J. Martínez, J.-P. Tetienne, T. Hingant, J.-F. Roch, K. Garcia, R. Soucaille, J. P. Adam, J.-V. Kim, S. Rohart, A. Thiaville, J. Torrejon, M. Hayashi, and V. Jacques The Dzyaloshinskii-Moriya Interaction (DMI) has recently attracted considerable interest owing to its fundamental role in the stabilization of chiral spin textures in ultrathin ferromagnets, which are interesting candidates for novel spintronic technologies. Here, the authors present an experimental study of the DMI strength that is induced in nanometer-thick CoFeB ferromagnetic thin films in contact with different nonmagnetic metal underlayers. They use a novel technique for noninvasive high-sensitivity sensing of magnetic field: a scanning nanomagnetometer based on the magnetic response of a single nitrogen-vacancy defect in diamond. The magnetic domain walls are mapped, the spin structure and type of domain wall determined, and the DMI strength extracted. Importantly, the authors find local variation of the DMI constant, which clearly suggests that local field mapping techniques are extremely important to study this physics. [Phys. Rev. B 94, 064413] Published Thu Aug 11, 2016
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    GPCR conformational dynamics [Pharmacology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-05-23
    Description: The dynamic character of G protein-coupled receptors is essential to their function. However, the details of how ligands stabilize a particular conformation to selectively activate a signaling pathway and how signaling proteins affect this conformational repertoire remain unclear. Using a prototypical peptide-activated class A G protein-coupled receptor (GPCR), the ghrelin receptor, reconstituted as a monomer into lipid discs and labeled with a fluorescent conformational reporter, we demonstrate that ligand efficacy and functional selectivity are directly related to different receptor conformations. Of importance, our data bring direct evidence that distinct effector proteins affect the conformational landscape of the ghrelin receptor in different ways. Whereas G proteins affect the balance between active and inactive receptor substates in favor of the active state, agonist-induced arrestin recruitment is accompanied by a marked change in the structural features of the receptor that adopt a conformation different from that observed in the absence of arrestin. In contrast to G proteins and arrestins, μ-AP2 has no significant effect on the organization of the transmembrane core of the receptor. Such a modulation of a GPCR conformational landscape by pharmacologically distinct ligands and effectors provides insights into the structural bases that decisively affect ligand efficacy and subsequent biological responses. This is also likely to have major implications for the design of drugs activating specific GPCR-associated signaling pathways.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Benchmark of algorithms for solar clear-sky detection (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-05-21
    Description: Nowadays, solar resource estimation via clear-sky models is widely accepted when correctly validated with on ground records. In the past, different approaches have been proposed in order to determine clear-sky periods of solar radiation on-ground records: visual inspection of registers, discretization via a threshold value of clear sky index, and correlation with estimated clear sky solar irradiation. However, due to the fact that the process must be automated and the need for universality, the search for clear-sky conditions presents a challenging feat. This study proposes a new algorithm based on the persistent value of the Linke turbidity in conjunction with a transitory filter. The determinant of the correlation matrix of estimated clear-sky solar irradiance and measured irradiance is calculated to distinguish between days under clear-sky conditions and cloudy or overcast days. The method was compared and proved superior against a review of other 10 commonly used techniques at 21 sites of the Baseline Surface Radiation Network, which includes diverse climates and terrain.
    Electronic ISSN: 1941-7012
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by American Institute of Physics (AIP)
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  • 4
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    Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy (2013)
    Oxford University Press
    Details
    Publication Date: 2013-07-26
    Description: X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disorder of the nervous system characterized by axonopathy in spinal cords and/or cerebral demyelination, adrenal insufficiency and accumulation of very long-chain fatty acids (VLCFAs) in plasma and tissues. The disease is caused by malfunction of the ABCD1 gene, which encodes a peroxisomal transporter of VLCFAs or VLCFA-CoA. In the mouse, Abcd1 loss causes late onset axonal degeneration in the spinal cord, associated with locomotor disability resembling the most common phenotype in patients, adrenomyeloneuropathy. We have formerly shown that an excess of the VLCFA C26:0 induces oxidative damage, which underlies the axonal degeneration exhibited by the Abcd1 – mice. In the present study, we sought to investigate the noxious effects of C26:0 on mitochondria function. Our data indicate that in X-ALD patients' fibroblasts, excess of C26:0 generates mtDNA oxidation and specifically impairs oxidative phosphorylation (OXPHOS) triggering mitochondrial ROS production from electron transport chain complexes. This correlates with impaired complex V phosphorylative activity, as visualized by high-resolution respirometry on spinal cord slices of Abcd1 – mice. Further, we identified a marked oxidation of key OXPHOS system subunits in Abcd1 – mouse spinal cords at presymptomatic stages. Altogether, our results illustrate some of the mechanistic intricacies by which the excess of a fatty acid targeted to peroxisomes activates a deleterious process of oxidative damage to mitochondria, leading to a multifaceted dysfunction of this organelle. These findings may be of relevance for patient management while unveiling novel therapeutic targets for X-ALD.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 5
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    A small long-life acoustic transmitter for studying the behavior of aquatic animals (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-11-22
    Description: Acoustic telemetry is an important tool for studying the behavior of aquatic animals and assessing the environmental impact of structures such as hydropower facilities. However, the physical size, signal intensity, and service life of off-the-shelf transmitters are presently insufficient for monitoring certain species. In this study, we developed a small, long-life acoustic transmitter with an approximate length of 24.2 mm, diameter of 5.0 mm, and dry weight of 0.72 g. The transmitter generates a coded acoustic signal at 416.7 kHz with a selectable source level between 159 and 163 dB relative to 1 μ Pa at 1 m, allowing a theoretical detection range of up to 500 m. The expected operational lifetime is 1 yr at a pulse rate interval of 15 s. The new technology makes long-term acoustic telemetry studies of small fish possible, and is being deployed for a long-term tracking of juvenile sturgeon.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Published by American Institute of Physics (AIP)
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  • 6
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    Backarc basin inversion and subcontinental mantle emplacement in the crust: kilometre-scale folding and shearing at the base of the proto-Alboran lithospheric mantle (Betic Cordillera, southern Spain) (2013)
    Geological Society of London
    Details
    Publication Date: 2013-01-05
    Description: To constrain the latest evolutionary stages and mechanisms of exhumation and emplacement of subcontinental peridotites in the westernmost Mediterranean, we present here a detailed structural study of the transition from granular spinel peridotite to plagioclase tectonite in the western Ronda Peridotite (Betic Cordillera, southern Spain). We show that the plagioclase tectonite foliation represents an axial surface particularly well developed in the reverse limb of a downward facing moderately plunging and moderately inclined synform at the base of the Ronda massif. The fold limbs are cut by several mylonitic and ultramylonitic shear zones with top-to-the-SW sense of shear. After restoring the middle to late Miocene vertical-axis palaeomagnetic rotation and the early Miocene tectonic tilting of the massif, these studied structures record southward-directed kinematics. We propose a geodynamic model in which folding and shearing of an attenuated mantle lithosphere occurred by backarc basin inversion during late Oligocene (23–25 Ma) southward collision of the Alborán Domain with the palaeo-Maghrebian passive margin, leading to the intracrustal emplacement of peridotites in the earliest Miocene (21–23 Ma).
    Print ISSN: 0016-7649
    Topics: Geosciences
    Published by Geological Society of London
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  • 7
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    Analysis of sedimentary processes on the Las Canteras beach (Las Palmas, Spain) for its planning and management (1990)
    Elsevier
    Details
    Publication Date: 1990-12-01
    Print ISSN: 0013-7952
    Electronic ISSN: 1872-6917
    Topics: Geosciences
    Published by Elsevier
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  • 8
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    Precision Nutrition and Metabolic Syndrome Management (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-03-31
    Description: Precision nutrition is an emerging concept encompassing an integrated action considering not only the genetic/epigenetic makeup and ethnic aspects of individuals, but other personalized phenotypical features, such as family and individual clinical issues, previous diseases and therapeutic treatments, perinatal nutrition, food likes/dislikes, allergies/intolerances, lifestyle attitudes and patterns, social and cultural circumstances or religious beliefs, etc. In this context, chronic disease prevalence is a global public health problem itself, which is also accompanied by a number of complications, including insulin resistance, hypertension, hypercholesterolemia, fatty liver, inflammation, oxidative status and immunocompetence disturbances, and other adverse manifestations related to metabolic syndrome, which may need individualized nutritional approaches. Therefore, the current Special Issue attempts to provide specific nutritional strategies to prevent or treat the complications associated with metabolic syndrome features concerning diabetes, vascular events, liver diseases, dyslipemia, and cancer with a precision nutrition scope.
    Keywords: RA1-1270 ; Dietary patterns ; Precision nutrition ; Bioactive compounds ; Nutritional management of disease ; Nutritional intervention ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine
    Language: English
    Format: image/png
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    E-BOOK
  • 9
    Electronic Resource
    Electronic Resource
    Critical study of chromatic parameters in color break indicator evaluation (1986)
    s.l. : American Chemical Society
    Analytical chemistry 58 (1986), S. 200-202 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00292a048
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    The Hiendelaencina mining district (Guadalajara, Spain) (1992)
    Springer
    Mineralium deposita 27 (1992), S. 206-212 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Hiendelaencina mining district (Guadalajara, Spain), includes the ore deposits of the Hiendelaencina, La Bodera and Congostrina areas. In this paper a general overview of this district is given, with special emphasis on the parageneses, mineralizing stages and chemical characteristics of the sulphides and sulphosalts. These deposits contain silver in Sb-rich sulphosalts such as freibergite, pyrargyrite, polybasite, stephanite, freieslebenite and the Bi-rich sulphosalt, aramayoite. Three mineralizing stages have been detected in Hiendelaencina and Congostrina: (1) As-Fe; (2) Cu-Zn-Fe-Sb-Ag; and (3) Pb-Sb-Ag (±Bi) but only two in La Bodera (stages 2 and 3). The average sulphosalt formulas are: freibergite (Cu0.5 Ag5.9) (Fe1.42 Zn0.66) (Sb4.49 As0.02) S13; pyrargyrite Ag3.38 Sb1.0 S3; polybasite (Ag16.3Cu0.15) (Sb2.8 As0.15) S11; stephanite Ag6.7 Sb1.38 S4; freieslebenite Ag1.1 Sb0.83 Pb1.05 S3 and aramayoite Ag1.06 Bi0. 35 Sb0.7 Pb0.03 S2. The compositional patterns of these sulphosalts (mainly based on the Sb/(Sb + Ag), Ag/ (Ag + Cu), Sb(Ag + As) and Ag/(Ag + Cu) ratios) are outlined, pointing broadly to similar tendencies in their chemistry and genetic conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202544
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