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  • 1
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    Obesity drug pipeline not so fat (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-02-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, Trisha -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):849-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574616" target="_blank"〉PubMed〈/a〉
    Keywords: Agouti-Related Protein ; Animals ; Anti-Obesity Agents/adverse effects/pharmacology/*therapeutic use ; Appetite/drug effects ; Arcuate Nucleus of Hypothalamus/metabolism ; Ciliary Neurotrophic Factor/therapeutic use ; Clinical Trials as Topic ; Cyclobutanes/adverse effects/therapeutic use ; Energy Intake ; Ghrelin ; Humans ; Hunger/drug effects ; Intercellular Signaling Peptides and Proteins ; Lactones/adverse effects/therapeutic use ; Leptin/metabolism/therapeutic use ; Mice ; Nerve Tissue Proteins/adverse effects/therapeutic use ; Neurons/metabolism ; Neuropeptide Y/metabolism/pharmacology ; Obesity/*drug therapy/metabolism ; Peptide Fragments ; Peptide Hormones/metabolism/pharmacology ; Peptide YY/metabolism/pharmacology ; Phentermine/adverse effects/therapeutic use ; Proteins/metabolism ; Receptors, Corticotropin/metabolism ; Receptors, Melanocortin ; Weight Loss ; alpha-MSH/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Obesity. Enzyme blocker prompts mice to shed weight (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-05
    Description: A multidisciplinary team may have discovered an important new weapon in the battle of the bulge. On page 2379 of this issue, the team reports that a molecule that is needed for fat synthesis in the body may play a key role in appetite signaling in the brain. Moreover, the investigators produced a synthetic inhibitor of this molecule that spurred a dramatic drop in appetite and weight in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2000 Jun 30;288(5475):2299-300.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10917820" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite/drug effects ; Appetite Depressants/*pharmacology ; Brain/metabolism ; Enzyme Inhibitors/*pharmacology ; Fasting ; Fatty Acid Synthases/*antagonists & inhibitors ; Humans ; Liver/drug effects/metabolism ; Malonyl Coenzyme A/metabolism ; Mice ; Neuropeptide Y/genetics/metabolism ; Obesity/*drug therapy ; RNA, Messenger/genetics/metabolism ; Weight Loss/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Obesity research. Tracing leptin's partners in regulating body weight (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2000 Mar 10;287(5459):1738-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10755923" target="_blank"〉PubMed〈/a〉
    Keywords: Adipocytes/metabolism ; Animals ; Appetite/physiology ; *Body Weight ; Carrier Proteins/genetics/metabolism ; Humans ; Hypothalamic Hormones/genetics/physiology ; Hypothalamus/*physiology ; Leptin/genetics/metabolism/*physiology ; Melanins/genetics/physiology ; Muscles/metabolism ; Neuropeptide Y/genetics/physiology ; Neuropeptides/physiology ; Obesity/genetics/*physiopathology ; Pituitary Hormones/genetics/physiology ; Pro-Opiomelanocortin/genetics/physiology ; Proteins/genetics/physiology ; *Receptors, Cell Surface ; Receptors, Leptin ; *Repressor Proteins ; Suppressor of Cytokine Signaling Proteins ; *Transcription Factors ; alpha-MSH/genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Reaping the plant gene harvest (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-02-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2000 Jan 21;287(5452):412-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10671160" target="_blank"〉PubMed〈/a〉
    Keywords: DNA Transposable Elements ; Databases, Factual ; Enhancer Elements, Genetic ; Gene Expression Profiling ; Gene Expression Regulation, Plant ; *Genes, Plant ; *Genetic Techniques ; Genome, Plant ; Mutagenesis ; Oligonucleotide Array Sequence Analysis ; Physical Chromosome Mapping ; Plant Proteins/genetics/physiology ; Plants/*genetics/*metabolism ; Proteome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Obesity research. Pot-bellied mice point to obesity enzyme (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2001 Dec 7;294(5549):2071-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11739926" target="_blank"〉PubMed〈/a〉
    Keywords: 11-beta-Hydroxysteroid Dehydrogenase Type 2 ; Abdomen ; Adipose Tissue/*enzymology/metabolism ; Animals ; Body Composition ; Diabetes Mellitus/enzymology/metabolism ; Enzyme Inhibitors/pharmacology ; Humans ; Hydrocortisone/blood/*metabolism ; Hydroxysteroid Dehydrogenases/antagonists & inhibitors/genetics/*metabolism ; Hypoglycemic Agents/pharmacology ; Male ; Metabolic Syndrome X ; Mice ; Mice, Transgenic ; Obesity/*enzymology/genetics/metabolism ; Skin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Genetics. SNP-ing drugs to size (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):595.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474082" target="_blank"〉PubMed〈/a〉
    Keywords: *Aryl Hydrocarbon Hydroxylases ; Cytochrome P-450 CYP3A ; Cytochrome P-450 Enzyme System/genetics/*metabolism ; Humans ; Oxidoreductases, N-Demethylating/genetics/*metabolism ; Pharmaceutical Preparations/*metabolism ; *Pharmacogenetics ; *Polymorphism, Single Nucleotide
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Innate immunity. Ancient system gets new respect (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2001 Mar 16;291(5511):2068-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11256394" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Infective Agents/chemistry/therapeutic use ; Antimicrobial Cationic Peptides/chemistry/*immunology/physiology/therapeutic use ; Bacterial Infections/drug therapy/prevention & control ; Cell Membrane/drug effects/metabolism ; Clinical Trials as Topic ; Defensins/chemistry/immunology/physiology/therapeutic use ; *Drosophila Proteins ; Humans ; *Immunity, Innate ; Membrane Glycoproteins/metabolism ; Mycoses/drug therapy ; Peptides/chemistry/*immunology/physiology/*therapeutic use ; Receptors, Cell Surface/metabolism ; Signal Transduction/drug effects ; Toll-Like Receptors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Obesity research. Leptin not impressive in clinical trial (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1999 Oct 29;286(5441):881-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10577231" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic ; Diet ; Humans ; Leptin/adverse effects/*therapeutic use ; Obesity/*drug therapy ; Treatment Outcome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Gene defect linked to Rett syndrome (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1999 Oct 1;286(5437):27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10532886" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosomal Proteins, Non-Histone ; Chromosome Mapping ; DNA-Binding Proteins/*genetics ; Female ; *Gene Expression Regulation ; Humans ; Male ; Methyl-CpG-Binding Protein 2 ; Mice ; Mice, Knockout ; Mutation ; Repressor Proteins/*genetics ; Rett Syndrome/*genetics ; X Chromosome/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    New ways to glean medicines from plants (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-09-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1999 Aug 27;285(5432):1347, 1349.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10490408" target="_blank"〉PubMed〈/a〉
    Keywords: *Biotechnology ; Drug Evaluation, Preclinical ; Genetic Engineering ; Humans ; *Pharmaceutical Preparations ; Plant Roots/*metabolism ; Plants/*metabolism ; Plants, Genetically Modified/*metabolism ; Recombinant Proteins/*biosynthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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