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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 85 (1963), S. 1241-1244 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 77 (1955), S. 5472-5476 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 79 (1957), S. 782-791 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 89 (1961), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 10990-10996 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Explicit expressions are derived for the equilibrium configurations of long segments of a DNA double helix subject to boundary conditions of the type imposed by DNA-bending proteins at the ends of otherwise free segments. The expressions, which are exact within the framework of Kirchhoff's theory of elastic rods, show that, in appropriate ranges of parameters, small changes in end conditions can result in large changes in tertiary structure. A discussion is given of the implications of this observation for understanding the action of bending proteins and of proteins that induce topological transitions that change the linking number of closed loops of DNA. © 1994 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 103 (1995), S. 9101-9109 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Explicit solutions of the equations of Kirchhoff's theory of elastic rods are employed to derive properties of the tertiary structure of a looped segment of DNA that is subject to geometric constraints imposed at its end points by bound proteins. In appropriate circumstances small changes in such boundary data cause a nearly planar loop to undergo a continuous and reversible transition that can be described as a 180° rotation taking the loop from an uncrossed to a singly crossed structure in which sequentially separated base pairs are brought into proximity. Expressions are derived relating points and angles of crossing to end conditions, and results are presented that facilitate the calculation of changes in elastic energy during such transitions. © 1995 American Institute of Physics.
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  • 7
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 105 (1996), S. 2517-2526 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: New explicit solutions are obtained for the nonlinear equations of Kirchhoff's theory of the dynamics of inextensible elastic rods without neglect of rotatory inertia. These exact solutions describe a class of motions possible in closed circular rings possessing a uniform distribution of intrinsic curvature ku and intrinsic torsion. When ku≠0, the motions in this class are such that the axial curve of the ring remains stationary while the cross sections rotate about their centers in such a way that the angle ψ of rotation is independent of axial location and is governed by the nonlinear pendulum equation. When ku=0, such uniform rotation of cross sections can occur at an arbitrary steady rate. The methods of classical equilibrium statistical mechanics yield the following conclusions for canonical ensembles of rings for which the motion is this type of pure homogeneous torsion. When 1/ku=11.85 nm (i.e., when the intrinsic curvature ku is among the highest observed in naturally occurring, approximately uniformly curved, stress-free DNA segments), if the flexural rigidity is assigned a value usually accepted for duplex DNA, at T=298 K the root-mean-square value, 〈ψ2〉1/2, of the angle ψ is 11.2°. For motions in this class, the heat capacity per ring, as a function of T/ku, shows a maximum which, when T=298 K, occurs where 1/ku=127 nm and corresponds to an ensemble of rings of which approximately 1% have sufficient energy for escape over the barrier associated with the separatrix between periodic and monotone solutions of the nonlinear pendulum equation; for that ensemble of rings, 〈ψ2〉1/2=43.3°. © 1996 American Institute of Physics.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Annali di matematica pura ed applicata 108 (1976), S. 189-199 
    ISSN: 1618-1891
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary The existence and uniqueness of free energy functions is demonstrated for a class of materials broad enough to contain as special cases those of the theory of finite elasticity, the theory of hypo-elasticity, and the theory of internal state variables for which the path of evolution is invariant under rescalings of time.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mathematical biology 7 (1979), S. 281-301 
    ISSN: 1432-1416
    Keywords: Ecology ; Population dynamics ; Semelparous species
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Summary The theory discussed in the first two papers, I and II, of this series is here generalized so that it is applicable to a population which obeys, at each instant t, the following two assumptions: (i) the rate- Dx(a, t) at which the population loses individuals of age a through death and dispersal is given by a function γt of a and the number x(a, t) of individuals which have age a, i.e.-Dx(a, t)=γt(x(a, t), a) and (ii) the number x(0, t) of newly born individuals is given by a function Ft of the number x(af, t) of individuals at a specified age af of fecundity, i.e. x(0, t)=Ft(x(af, t)). The ‘autonomous case’ in which the functions γt and Ft are independent of the subscript t corresponds to the theory developed in I and II. The present article contains a treatment of the case in which the population is in a ‘periodic environment’ in the sense that the mapping t ↦ (γt, Ft) is periodic with a period which is an integral multiple N of af. Under the assumption that for each pair (t, a) the function γt(·, a) is convex and the function Ft(·) is strictly increasing and concave, it is shown that when the environment is periodic, a given population can be expected to belong to one of three classes, regardless of initial conditions: (A) the class of ‘endangered populations’ for which the abundance function x eventually decays to zero, (B) the class of ‘asymptotically periodic populations’ for which as time increases x approaches a non-zero function x* which is periodic in time with period Naf, and (C) the class of populations which exhibit unbounded growth. The properties of the loss functions γt and fecundity functions Ft which determine the class to which a population belongs are found and discussed, and formulae are given for the stable periodic abundance function x* of a population in class B. In a discussion of the domain of application of the theory, it is pointed out that when reproduction is seasonal and is followed by mortality, the assumption that an individual interacts only with others of the same age is a reasonable one.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of mathematical biology 12 (1981), S. 343-354 
    ISSN: 1432-1416
    Keywords: Ecology ; Periodic differential equations ; Optimization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Summary The theory developed here applies to populations whose size x obeys a differential equation, $$\dot x = r(t)xF(x,t)$$ in which r and F are both periodic in t with period p. It is assumed that the function r, which measures a population's intrinsic rate of growth or intrinsic rate of adjustment to environmental change, is measurable and bounded with a positive lower bound. It is further assumed that the function F, which is determined by the density-dependent environmental influences on growth, is such that there is a closed interval J, with a positive lower bound, in which there lies, for each t, a number K(t) for which $$F(K(t),t) = 0$$ and, as functions on J × ℝ, F is continuous, while ∂F/∂x is continuous, negative, and bounded. Because x(t) = 0, 〉 0, or 〈 0 in accord with whether K(t) = x(t), K(t) 〉 x(t), or K(t) 〈 x(t), the number K(t) is called the “carrying capacity of the environment at time t”. The assumptions about F imply that the number K(t) is unique for each t, depends continuously and periodically on t with period P, and hence attains its extrema, K min and K max. It is, moreover, easily shown that the differential equation for x has precisely one solution x * which has its values in J and is bounded for all t in ℝ; this solution is of period p, is asymptotically stable with all of J in its domain of attraction, and is such that its minimum and maximum values, x min * and x max * , obey $$K_{min} \leqslant x_{min}^* \leqslant x_{max}^* \leqslant K_{max}^* .$$ The following question is discussed: If the function F is given, and the function r can be chosen, which choices of r come close to maximizing, x min * ? The results obtained yield a procedure for constructing, for each F and each ɛ 〉 0, a function r such that x min * 〉 K max − ɛ.
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