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  • 1
    Electronic Resource
    Electronic Resource
    Detailed 1H- and 13C-Nmr Investigations of Some Diterpenes Isolated from Leonurus persicus (1995)
    s.l. : American Chemical Society
    Journal of natural products 58 (1995), S. 1543-1554 
    Details
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/np50124a010
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Lagotoside: A New Phenylpropanoid Glycoside from Lagotis stolonifera (1991)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 74 (1991), S. 1273-1277 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: From the aerial parts of Lagotis stolonifera (Scrophulariaccae), a new phenylpropanoid glycoside, lagotoside (8), and the three known glycosides ehrenoside (5), verbascoside (= acteoside; 6), and plantamajoside (7) were isolated, together with the four known iridoid glucosides aucubin (1), catalpol(2), globularin (4), and lythantosalin (3). The structure of the new compound 8 was elucidated on the basis of chemical and spectral data as 2-(3-hy-droxy-4-methoxyphenyl)ethyl O-[α-L-arabinopyranosyl-(1 → 2)]-O-[α-L-rhamnopyranosyl-(1 → 3)]-4-O-feruloyl-β-D-glucopyranoside.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19910740615
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    Paper (German National Licenses)
    Fulltext
  • 3
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    Raman and FTIR spectra of larval bivalve shells (2018)
    PANGAEA
    In:  Supplement to: Ramesh, Kirti; Melzner, Frank; Griffith, Andrew W; Gobler, Christopher J; Rouger, Caroline; Tasdemir, Deniz; Nehrke, Gernot (2018): In vivo characterization of bivalve larval shells: a confocal Raman microscopy study. Journal of The Royal Society Interface, 15(141), 20170723, https://doi.org/10.1098/rsif.2017.0723
    Details
    Publication Date: 2023-06-24
    Description: In vivo confocal Raman microscopy (CRM), polarized light microscopy and Fourier transform infrared spectroscopy (FTIR) were used to determine if a significant amount of amorphous calcium carbonate (ACC) exists within larval shells of Baltic mytilid mussels (Mytilus edulis-like) and whether the amount of ACC varies during larval development. No evidence for ACC was found from the onset of shell deposition at 21 h post-fertilization (hpf) until 48 hpf. Larval Mytilus shells were crystalline from 21 hpf onwards and exhibited CRM and FTIR peaks characteristic of aragonite. Prior to shell deposition at 21 hpf, no evidence for carbonates was observed through in vivo CRM. We further analysed the composition of larval shells in three other bivalve species, Mercenaria mercenaria, Crassostrea gigas and Crassostrea virginica and observed no evidence for ACC, which is in contrast to previous work on the same species. Our findings indicate that larval bivalve shells are composed of crystalline aragonite and we demonstrate that conflicting results are related to sub-optimal measurements and misinterpretation of CRM spectra. Our results demonstrate that the common perception that ACC generally occurs as a stable and abundant precursor during larval bivalve calcification needs to be critically reviewed.
    Keywords: Analytical method; Sample code/label; Species; Transmission of light; Wave number
    Type: Dataset
    Format: text/tab-separated-values, 143020 data points
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    DATA PANGAEA
  • 4
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    Isolation and untargeted metabolomics of microorganisms from the mesopelagic jellyfish Periphylla periphylla (2023)
    PANGAEA
    Details
    Publication Date: 2023-08-08
    Description: This study aimed at isolating microorganisms associated with the mesopelagic jellyfish Periphylla periphylla collected in Irminger Sea at a depth of 325 m in July 2020. Three different solid cultivation media; Hastings, Marine agar and Wickerham media were used for the isolation of the associated microorganisms. A total of 43 bacteria were isolated from the inner and outer surfaces of the umbrella of P. periphylla, but unfortunately, no fungal strain was isolated. Isolates were further identified by Sanger sequencing of the 16S rRNA gene, and based on phylogenetic distinctiveness (differences in closest relative species according to the nucleotide BLAST), 16 bacteria belonging to 8 different genera were selected and subjected to an OSMAC cultivation regime approach using liquid and solid marine broth and glucose– yeast–malt media. After 7 days of cultivation, cultures were extracted with ethyl acetate and assessed for antimicrobial activity against fish and human pathogens. Based on antimicrobial activity assessment, four most bioactive strains; Polaribacter sp. SU124, Shewanella sp. SU126, Psychrobacter sp. SU143 and Psychrobacter sp. SU137, were prioritized for a comparative and untargeted metabolomics analysis using feature-based molecular networking. These findings highlight the biotechnological potential of P. periphylla-associated microbiota.
    Keywords: Laboratory experiment; SUMMER; Sustainable Management of Mesopelagic Resources
    Type: Dataset
    Format: application/zip, 2 datasets
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    DATA PANGAEA
  • 5
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    Identification of bacteria isolated from the mesopelagic jellyfish Periphylla periphylla (2023)
    PANGAEA
    Details
    Publication Date: 2024-03-18
    Description: Identification of 16 selected bacteria associated to the umbrella of Periphylla periphylla collected in the Irminger Sea based on sequencing of the 16S ribosomal RNA gene and BLAST against the NCBI nucleotide database. The table displays the first 3 hits from two blastn searches, one against all database entries and the second against type strains only. Nucleotide identities (%) with database hits and NCBI accession numbers assigned to the isolated bacteria are also displayed. Colonies were cultured either in marine broth, Hastings medium or Wickerham medium for comparison.
    Keywords: A7-2020; A7-2020_417; Accession number, genetics; Arni Fridriksson; Bacterial strain; Basic Local Alignment Search Tool, National Center for Biotechnology Information, Nucleotide BLAST; blastn; Gene name; Identity; IESSNS_2020; Laboratory experiment; Multipurpose pelagic trawl - 832; MULTPELT-832; Nordic Seas; Sanger Sequencing modified after Sanger et al. (1977); Sequence length; Source material; Species, unique identification; Species, unique identification (Semantic URI); Species, unique identification (URI); SUMMER; Sustainable Management of Mesopelagic Resources; Temperature, air; Treatment: culture medium; Type of study; VID; Visual identification
    Type: Dataset
    Format: text/tab-separated-values, 720 data points
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    DATA PANGAEA
  • 6
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    Annotation of metabolites produced by bacteria isolated from the mesopelagic jellyfish Periphylla periphylla (2023)
    PANGAEA
    Details
    Publication Date: 2024-03-18
    Description: Putative annotation of metabolites produced by the Psychrobacter sp. SU143, Psychrobacter sp. SU137, Shewanella sp. SU126 and Polaribacter sp. SU124 in the liquid and solid regime of Marine Broth and Glucose-Yeast-Malt media. Annotation was based on the m/z [M+H]+ or other adducts, retention time, predicted molecular formula, fragmentation pattern and source of the hit. The source of the ion is indicated by the area under a peak (peak area count). Confidence level of annotation are given based on the reporting standards proposed by Sumner, et al. 2007, i.e. identified compound, is putative annotation without reference standards, is putative characterized compound class, and is unknown compound. The mass spectrometry data used for the molecular networking analysis were deposited in the MassIVE Public GNPS database under the accession number MSV000091067.
    Keywords: A7-2020; A7-2020_417; Adduct ion; Annotation; Arni Fridriksson; Bacterial strain; Class, compound; Confidence level; Feature-based molecular networking according to Nothias et al. 2020; Fragment ion, molecular mass; Genus, unique identification; Genus, unique identification (Semantic URI); Genus, unique identification (URI); IESSNS_2020; Laboratory experiment; LC-MS/MS; Molecular formula; Multipurpose pelagic trawl - 832; MULTPELT-832; Nordic Seas; Parent ion, molecular mass; Peak area; Retention time; Sanger Sequencing modified after Sanger et al. (1977); SUMMER; Sustainable Management of Mesopelagic Resources; Temperature, air; Treatment: culture medium; Type of study; Ultra-high-performance liquid chromatography (UHPLC), Waters, Acquity UPLC I-Class System; coupled with quadrupole-time-of-flight mass spectrometer, Waters, Xevo G2-XS QToF; Uniform resource locator/link to reference
    Type: Dataset
    Format: text/tab-separated-values, 10257 data points
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    DATA PANGAEA
  • 7
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    Bioactivity and metablome profile of marine microorganisms isolated from arctic deep-sea sediments (2019)
    In:  EPIC3International Symposium on Marine Natural Products, Peniche, Portugal, 2019-09-01-2019-09-05
    Details
    Publication Date: 2019-09-16
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 8
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    Bioactivity Screening of Microorganisms Isolated from Arctic Ocean Deep-Sea Sediment (2019)
    In:  EPIC3BIOPROSP: International Conference on Marine Bioprospecting and Biotechnology, Tromsø, Norway, 2019-02-11-2019-02-13
    Details
    Publication Date: 2019-02-11
    Description: Oceans cover 〉70% of the earth and encompass variable habitats concerning salinity, temperature, pressure, light availability. The deep sea (〉1000 m water depth) constitutes more than 60% of the ocean´s biosphere and harbors an unparalleled biodiversity. It constitutes an extreme habitat due to high pressure, darkness and often low nutrient and oxygen concentrations. In order to ensure their survival, microorganisms thriving in such environments have to develop unique metabolic adaptations, thus represent an interesting resource for the discovery of new molecules. However, due to access difficulties to deep-sea habitats and the lack of suitable and affordable sampling techniques, deep-sea microorganisms have remained untapped for their potential in marine biodiscovery. In this study, we obtained deep-sea sediment samples from Arctic Ocean (-2432 m), sampled by an ROV during RV Polarstern expedition 108. Isolation of microorganisms has been performed using two specific media for bacteria and fungi, respectively. Isolates were identified by amplification of the 16S rRNA gene (bacteria) and ITS1-2 region (fungi) followed by Sanger sequencing. In total, 70 bacterial isolates were identified covering four phyla (52 Firmicutes, 1 Actinobacteria, 11 Proteobacteria and 6 Bacteroidetes) and seven fungal strains from two different phyla (6 Ascomycota and 1 Basidiomycota). Selected isolates were cultivated in two different media, followed by solvent (EtOAc) extraction and bioactivity screenings against a panel of clinically relevant microbial pathogens and six cancer cell lines. At 100 µg/mL concentration, three bacterial extracts showed antitumor activity (〉70%), whereas 17 exhibited activity (〉65%) against methicillin-resistant Staphylococcus aureus (MRSA). Notably, only one fungus showed a cultivation medium dependent-high antifungal activity (〉90%), highlighting the impact of culture media on the production of bioactive secondary metabolites.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 9
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    In vivo characterization of bivalve larval shells: a confocal Raman microscopy study (2018)
    The Royal Society Publishing
    In:  EPIC3Journal of The Royal Society Interface, The Royal Society Publishing, 15(141), pp. 20170723, ISSN: 1742-5689
    Details
    Publication Date: 2018-04-13
    Description: In vivo confocal Raman microscopy (CRM), polarized light microscopy and Fourier transform infrared spectroscopy (FTIR) were used to determine if a significant amount of amorphous calcium carbonate (ACC) exists within larval shells of Baltic mytilid mussels (Mytilus edulis-like) and whether the amount of ACC varies during larval development. No evidence for ACC was found from the onset of shell deposition at 21 h post-fertilization (hpf) until 48 hpf. Larval Mytilus shells were crystalline from 21 hpf onwards and exhibited CRM and FTIR peaks characteristic of aragonite. Prior to shell deposition at 21 hpf, no evidence for carbonates was observed through in vivo CRM.We further analysed the composition of larval shells in three other bivalve species, Mercenaria mercenaria, Crassostrea gigas and Crassostrea virginica and observed no evidence for ACC, which is in contrast to previous work on the same species. Our findings indicate that larval bivalve shells are composed of crystalline aragonite and we demonstrate that conflicting results are related to sub-optimal measurements and misinterpretation of CRM spectra. Our results demonstrate that the common perception that ACC generally occurs as a stable and abundant precursor during larval bivalve calcification needs to be critically reviewed.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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  • 10
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    Bioactivity and Metabolome Mining of Deep-Sea Sediment-Derived Microorganisms Reveal New Hybrid PKS-NRPS Macrolactone from Aspergillus versicolor PS108-62 (2023)
    In:  EPIC3Marine Drugs, 21, ISSN: 1660-3397
    Details
    Publication Date: 2023-02-02
    Description: Despite low temperatures, poor nutrient levels and high pressure, microorganisms thrive in deep-sea environments of polar regions. The adaptability to such extreme environments renders deep-sea microorganisms an encouraging source of novel, bioactive secondary metabolites. In this study, we isolated 77 microorganisms collected by a remotely operated vehicle from the seafloor in the Fram Strait, Arctic Ocean (depth of 2454 m). Thirty-two bacteria and six fungal strains that represented the phylogenetic diversity of the isolates were cultured using an One-Strain-Many-Compounds (OSMAC) approach. The crude EtOAc extracts were tested for antimicrobial and anticancer activities. While antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecium was common for many isolates, only two bacteria displayed anticancer activity, and two fungi inhibited the pathogenic yeast Candida albicans. Due to bioactivity against C. albicans and rich chemical diversity based on molecular network-based untargeted metabolomics, Aspergillus versicolor PS108-62 was selected for an in-depth chemical investigation. A chemical work-up of the SPE-fractions of its dichloromethane subextract led to the isolation of a new PKS-NRPS hybrid macrolactone, versicolide A (1), a new quinazoline (−)-isoversicomide A (3), as well as three known compounds, burnettramic acid A (2), cyclopenol (4) and cyclopenin (5). Their structures were elucidated by a combination of HRMS, NMR, [α]D, FT-IR spectroscopy and computational approaches. Due to the low amounts obtained, only compounds 2 and 4 could be tested for bioactivity, with 2 inhibiting the growth of C. albicans (IC50 7.2 µg/mL). These findings highlight, on the one hand, the vast potential of the genus Aspergillus to produce novel chemistry, particularly from underexplored ecological niches such as the Arctic deep sea, and on the other, the importance of untargeted metabolomics for selection of marine extracts for downstream chemical investigations.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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