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  • 1
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    Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP (2012)
    Springer Nature
    Details
    Publication Date: 2012-06-20
    Description: Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP Cell Death and Disease 3, e322 (June 2012). doi:10.1038/cddis.2012.66 Authors: X Zheng, X Zheng, X Wang, Z Ma, V Gupta Sunkari, I Botusan, T Takeda, A Björklund, M Inoue, S-B Catrina, K Brismar, L Poellinger & T S Pereira
    Keywords: hypoxiapancreatic β-cellsUPRER stressapoptosisCHOP
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation (2014)
    Oxford University Press
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    Publication Date: 2014-05-20
    Description: Histone H2A ubiquitination plays critical roles in transcriptional repression and deoxyribonucleic acid (DNA) damage response. More attention has been focused on ubiquitin E3 ligases of H2A, however, less is known about the negative regulators of H2A ubiquitination. Here we identified HSCARG as a new negative regulatory protein for H2A ubiquitination and found a possible link between regulator of H2A ubiquitination and cell cycle. Mechanistically, HSCARG interacts with polycomb repressive complex 1 (PRC1) and deubiquitinase USP7 and inhibits PRC1 ubiquitination in a USP7-dependent manner. As ubiquitination of PRC1 is critical for its E3 ligase activity toward H2A, HSCARG and USP7 are further shown to decrease the level of H2A ubiquitination. Moreover, we demonstrated that HSCARG is involved in DNA damage response through affecting the level of H2A ubiquitination and localization of RAP80 at lesion points. Knockout of HSCARG results in persistent activation of checkpoint signaling and leads to cell cycle arrest. This study unravels a novel mechanism for the regulation of H2A ubiquitination and elucidates how regulators of H2A ubiquitination affect cell cycle.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 3
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    Effect of sypQ gene on poly-N-acetylglucosamine biosynthesis in Vibrio parahaemolyticus and its role in infection process (2014)
    Oxford University Press
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    Publication Date: 2014-03-15
    Description: The syp locus includes four genes encoding putative regulators, six genes encoding glycosyltransferases, two encoding export proteins, and six other genes encoding unidentified functional proteins associated with biofilm formation and symbiotic colonization. However, the individual functions of the respective genes remain unclear. Amino acid alignment indicates that s ypQ is presumably involved in biosynthesizing poly- N -acetylglucosamine (PNAG), which is proposed to be a critical virulence factor in pathogen infection and is regarded as a target for protective immunity against a variety of Gram-negative/positive pathogens. However, no evidence showing that Vibrio parahaemolyticus also produces PNAG has been reported. Herein, the V. parahaemolyticus is confirmed to possess potential for producing PNAG for the first time. Our results indicated that gene sypQ is associated with PNAG biosynthesis and PNAG is involved in pathogen colonization. We propose that the function of pgaC in Escherichia coli could be taken over by sypQ from V. parahaemolyticus . We also tested whether PNAG can be used as a target against V. parahaemolyticus when it infects Pseudosciaena crocea . Our results showed that PNAG isolated from V. parahaemolyticus is an effective agent for decreasing V. parahaemolyticus invasion, implying that PNAG could be used to develop an effective vaccine against V. parahaemolyticus infection.
    Print ISSN: 0959-6658
    Electronic ISSN: 1460-2423
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 4
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    The catalogues and mid-infrared environment of interstellar OH masers (2014)
    Oxford University Press
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    Publication Date: 2014-05-31
    Description: Data for a number of OH maser lines have been collected from surveys. The positions are compared with recent mid-infrared (MIR) surveys such as the Spitzer Galactic Legacy Infrared Mid-Plane Survey Extraordinaire (GLIMPSE) and Wide-field Infrared Survey Explorer ( WISE ) surveys, restricting the comparison to point sources. The colours and intensities of the IR sources are compared. There are many 18-cm OH masers, but far fewer in lines arising from higher energy levels. We also make a comparison with 5-cm Class II methanol masers. We have divided the results into three subsamples: those associated with OH masers only, those associated with OH masers and Class II methanol masers and those associated with Class II methanol masers only. There are no obvious differences in the colour–colour or colour–magnitude results for the GLIMPSE point sources. However, according to the results from the WISE 22-μm survey, the sources associated with OH masers are brighter than those associated with methanol masers. We interpret the presence of OH and methanol masers as marking the locations of regions where stars are forming. The OH masers are located on the borders of sharp features found in the IR. These are referred to as bubbles. If the OH masers mark the positions of protostars, the result provides indirect evidence for triggered star formation caused by the expansion of the bubbles.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 5
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    Optimum design of exit guide vane on the bidirectional tubular turbine (2013)
    Institute of Physics (IOP)
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    Publication Date: 2013-12-22
    Description: Performance prediction about the forward generation condition based on a bidirectional through-flow turbine runner was conducted. The model characteristic curves and efficiency curve under reverse generation condition were plotted. In order to improve the reverse performance, exit guide vanes were lied behind the runner, the forward and reverse operating performance about a runner lied post-guide vane were numerically simulated. The results shows that the flow field distribution on forward generation condition did not significantly change after exit guide vanes were lied, and the energy conversion efficiency decreased. After exit guide vanes were lied, flow pattern of runner intake on under reverse generation condition were bettered, and the energy conversion efficiency increased. This study confirms that the exit guide vanes can improve the hydraulic performance of the turbine on reverse generation condition in view of numerical simulation.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 6
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    Further applications of the stochastic stress release model to historical earthquake data (1994)
    In:  Tectonophys., Kunming, China, 3-4, vol. 229, no. 4, pp. 101-122, pp. B05301, (ISSN: 1340-4202)
    Details
    Publication Date: 1994
    Keywords: Stress ; Statistical investigations ; Modelling ; Earthquake catalog ; Source parameters
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    BIBLIOGRAPHY SEISMOLOGY
  • 7
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    Paleomagnetic study of eastern Tibet - deformation of the Three Rivers region (1990)
    In:  Geophys. J. Int., Kyoto, AGU, vol. 103, no. 1-4, pp. 85-94, pp. 2215, (ISSN: 1340-4202)
    Details
    Publication Date: 1990
    Keywords: Plate tectonics ; China ; Paleomagnetism ; GJI
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    BIBLIOGRAPHY SEISMOLOGY
  • 8
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    Measuring temperature and field profiles in heat assisted magnetic recording (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-08-12
    Description: We introduce a theoretical and experimental framework that enables quantitative measurements of the temperature and magnetic field profiles governing the thermo-magnetic write process in heat assisted magnetic recording. Since our approach allows the identification of the correct temperature dependence of the magneto-crystalline anisotropy field in the vicinity of the Curie point as well, it provides an unprecedented experimental foundation to assess our understanding of heat assisted magnetic recording.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 9
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    Assessment of Marine Boundary Layer Cloud Simulations in the CAM with CLUBB and Updated Microphysics Scheme Based on ARM Observations from the Azores (2016)
    Wiley
    Details
    Publication Date: 2016-06-21
    Description: To assess marine boundary layer (MBL) cloud simulations in three versions of the Community Atmosphere Model (CAM), three sets of short-term global hindcasts are performed and compared to Atmospheric Radiation Measurement (ARM) program observations on Graciosa Island in the Azores from June 2009 to December 2010. The three versions consist of CAM5.3 with default schemes (CAM5.3), CAM5.3 with Cloud Layers Unified By Binormals (CLUBB-MG1), and CAM5.3 with CLUBB and updated microphysics scheme (CLUBB-MG2). Our results show that relative to CAM5.3 default schemes, simulations with CLUBB better represent MBL cloud-base height, the height of the major cloud layer, and the daily cloud cover variability. CLUBB also better simulates the relationship of cloud fraction to cloud liquid water path (LWP) most likely due to CLUBB's consistent treatment of these variables through a probability distribution function (PDF) approach. Sub-cloud evaporation of precipitation is substantially enhanced in simulations with CLUBB-MG2 and is more realistic based on the limited observational estimate. Despite these improvements, all model versions underestimate MBL cloud cover. CLUBB-MG2 reduces biases in in-cloud LWP (clouds are not too bright) but there are still too few of MBL clouds due to an underestimate in the frequency of overcast scenes. Thus combining CLUBB with MG2 scheme better simulates MBL cloud processes, but because biases remain in MBL cloud cover CLUBB-MG2 does not improve the simulation of the surface shortwave cloud radiative effect ( CRE SW ).
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 10
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    In situ Raman spectroscopic studies of FeS2 pyrite up to 675 K and 2100 MPa using a hydrothermal diamond anvil cell (2015)
    Mineralogical Society of Great Britain and Ireland
    Details
    Publication Date: 2015-04-29
    Description: Raman scattering experiments of natural FeS 2 pyrite were performed at simultaneous high-pressure and high-temperature conditions up to 675 K and 2100 MPa using a hydrothermal diamond anvil cell combined with micro-Raman spectroscopy. Four out of five Raman active modes [E g , A g , T g (1) and T g (3)] were resolved at ambient conditions, the remaining T g (2) [~377 cm –1 ] mode was weak and unresolved occurring ~2 cm –1 from the intense A g [379 cm –1 ] mode. The frequency shifts of the E g [343 cm –1 ] and A g [379 cm –1 ] modes were determined to be quadratic functions of pressure and temperature: 343 = 343.35 – 0.0178 x T – 8.4E–6 x ( T ) 2 + 0.00367 x p – 3.7E 7 x ( p ) 2 + 1.0E–6 x T x p and 379 = 379.35 – 0.0295 x T – 9.0E–6 x ( T ) 2 + 0.00460 x p – 5.3E–7 x ( p ) 2 + 7.0E–7 x T x p . The positive pressure dependence of both modes indicates stress-induced contraction of S–S and Fe–S bonds, whereas the negative temperature dependence shows temperature-induced expansion of them. The Raman spectra of pyrite were used to derive its bulk modulus at high temperatures, thermal expansion coefficient at high pressures and anharmonic parameters at high-pressure and high-temperature conditions.
    Print ISSN: 0026-461X
    Electronic ISSN: 1471-8022
    Topics: Geosciences
    Published by Mineralogical Society of Great Britain and Ireland
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