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  • Wiley-Blackwell  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of cooling and equilibration in DMSO, and cryopreservation of mouse oocytes, on the rates of in vitro fertilization, development, and chromosomal abnormalities (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 40 (1995), S. 110-115 
    Details
    ISSN: 1040-452X
    Keywords: Aneuploidy ; Cryoprotectant ; Fertility ; Polyploidy ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: In a previous study, we have shown that the cryopreservation of mouse oocytes caused increases in the rates of degeneration and of digynic polyploid embryos, while the fertility of frozen-thawed oocytes was decreased. In this study, we have attempted to determine the different stages in the complete freezing-thawing process which are deleterious for the oocytes and the subsequent zygotes. IVF assays showed that DMSO decreased the fertility of oocytes, whereas cooling to 0°C had no effect. DMSO, used at 0°C, was less deleterious for oocytes. Thus, the prefreezing manipulations seem to be important for the quality and fertility of oocytes. However, neither DMSO nor cooling increased the incidence of chromosomal abnormalities in embryos obtained from inseminated exposed oocytes. Therefore, the increased frequency of polyploidy observed in embryos after the cryopreservation of mouse oocytes must correspond to disruption occurring during the freezing-thawing process.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080400114
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  • 2
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    Systemic seismic risk assessment of road networks in urban areas (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2021-03-18
    Description: This article presents an integrated approach for the probabilistic systemic risk analysis of a road network considering spatial seismic hazard with correlation of ground motion intensities, vulnerability of the network components, and the effect of interactions within the network, as well as, between roadway components and built environment to the network functionality. The system performance is evaluated at the system level through a global connectivity performance indicator, which depends on both physical damages to its components and induced functionality losses due to interactions with other systems. An object-oriented modeling paradigm is used, where the complex problem of several interacting systems is decomposed in a number of interacting objects, accounting for intra- and interdependencies between and within systems. Each system is specified with its components, solving algorithms, performance indicators and interactions with other systems. The proposed approach is implemented for the analysis of the road network in the city of Thessaloniki (Greece) to demonstrate its applicability. In particular, the risk for the road network in the area is calculated, specifically focusing on the short-term impact of seismic events (just after the earthquake). The potential of road blockages due to collapses of adjacent buildings and overpass bridges is analyzed, trying to individuate possible criticalities related to specific components/subsystems. The application can be extended based on the proposed approach, to account for other interactions such as failure of pipelines beneath the road segments, collapse of adjacent electric poles, or malfunction of lighting and signaling systems due to damage in the electric power network.
    Description: Published
    Description: 524–540
    Description: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Description: JCR Journal
    Description: restricted
    Keywords: Systemic vulnerability ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
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    Probabilistic hazard for seismically induced tsunamis: accuracy and feasibility of inundation maps (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2017-04-04
    Description: Probabilistic tsunami hazard analysis (PTHA) relies on computationally demanding numerical simulations of tsunami generation, propagation, and non-linear inundation on high-resolution topo-bathymetric models. Here we focus on tsunamis generated by co-seismic sea floor dis- placement, that is, on Seismic PTHA (SPTHA). A very large number of tsunami simulations are typically needed to incorporate in SPTHA the full expected variability of seismic sources (the aleatory uncertainty). We propose an approach for reducing their number. To this end, we (i) introduce a simplified event tree to achieve an effective and consistent exploration of the seismic source parameter space; (ii) use the computationally inexpensive linear approximation for tsunami propagation to construct a preliminary SPTHA that calculates the probability of maximum offshore tsunami wave height (H Max) at a given target site; (iii) apply a two-stage filtering procedure to these ‘linear’ SPTHA results, for selecting a reduced set of sources and (iv) calculate ‘non-linear’ probabilistic inundation maps at the target site, using only the selected sources. We find that the selection of the important sources needed for approximating probabilistic inundation maps can be obtained based on the offshore HMax values only. The filtering procedure is semi-automatic and can be easily repeated for any target sites. We describe and test the performances of our approach with a case study in the Mediterranean that considers potential subduction earthquakes on a section of the Hellenic Arc, three target sites on the coast of eastern Sicily and one site on the coast of southern Crete. The comparison between the filtered SPTHA results and those obtained for the full set of sources indicates that our approach allows for a 75–80 per cent reduction of the number of the numerical simulations needed, while preserving the accuracy of probabilistic inundation maps to a reasonable degree.
    Description: Published
    Description: 574-588
    Description: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Description: JCR Journal
    Description: restricted
    Keywords: Tsunami ; Hazard ; Probabilistic ; Subduction ; Mediterranean ; SPTHA ; 04. Solid Earth::04.06. Seismology::04.06.02. Earthquake interactions and probability ; 04. Solid Earth::04.07. Tectonophysics::04.07.04. Plate boundaries, motion, and tectonics ; 04. Solid Earth::04.07. Tectonophysics::04.07.06. Subduction related processes
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 4
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    Considering uncertainties in the determination of earthquake source parameters from seismic spectra. (2016)
    Wiley-Blackwell
    Details
    Publication Date: 2020-02-05
    Description: In this paper, we present a method for handling uncertainties in the determination of the source parameters of earthquakes from spectral data. We propose a robust framework for estimating earthquake source parameters and relative uncertainties, which are propagated down to the estimation of basic seismic parameters of interest such as the seismic moment, the moment magnitude, the source size and the static stress drop. In practice, we put together a Bayesian approach for model parameter estimation and a weighted statistical mixing of multiple solutions obtained from a network of instruments, providing a useful framework for extracting meaningful data from intrinsically uncertain data sets. The Bayesian approach used to estimate the source spectra parameters is a simple but powerful mechanism for non-linear model fitting, providing also the opportunity to naturally propagate uncertainties and to assess the quality and uniqueness of the solution. Another important added value of such an approach is the possibility of integrating information from the expertise of seismologists. Such data can be encoded in a prior state of information that is then updated with the information provided by seismological data. The performance of the proposed approach is demonstrated analysing data from the 1909 April 23 earthquake occurred near Benavente (Portugal).
    Description: Published
    Description: 691-701
    Description: 2T. Tettonica attiva
    Description: JCR Journal
    Description: open
    Keywords: Fourier analysis ; Probability distributions ; Earthquake source observations ; Seismicity and tectonics ; 04. Solid Earth::04.02. Exploration geophysics::04.02.06. Seismic methods
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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