Publication Date:
1978-04-28
Description:
Mice treated with 6-hydroxydopamine before they were chronically fed phenobarbital did not develop functional barbiturate tolerance, measured by duration of the loss of righting reflex and hypothermia. Injection of 6-hydroxydopamine caused significant depletion of brain norepinephrine, while brain dopamine levels were not significantly depleted. Intact brain noradrenergic systems seem to be necessary for developing tolerance to the hypnotic and hypothermic effects of the barbiturates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tabakoff, B -- Yanai, J -- Ritzmann, R F -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):449-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/565533" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Behavior, Animal/drug effects
;
Body Temperature Regulation/drug effects
;
Brain/*drug effects
;
Drug Tolerance
;
Humans
;
Hydroxydopamines/pharmacology
;
Male
;
Mice
;
Norepinephrine/*metabolism
;
Phenobarbital/*pharmacology
;
Reflex/drug effects
;
Substance Withdrawal Syndrome/physiopathology
;
Substance-Related Disorders/physiopathology
;
Sympathetic Nervous System/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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