Publication Date:
1978-10-06
Description:
Sequential Giemsa-11 and C-band staining of the heterochromatic region of chromosome 1 from 30 unrelated individuals revealed a high degree of variability within this region, more than was identifiable with either stain alone. The Giemsa-11 stained material usually appeared as a single band of only slightly varying size within the heterochromatic region. The position of this band ranged from a location immediately adjacent to the centromere, to one farther along the long arm or at the junction of the C-band heterochromatin and euchromatin. Two individuals had a chromosome 1 with no detectable Giemsa-11 band but an average-size C-band. Two others with a large heterochromatic segment by C-banding had two Giemsa-11 positive bands. Additional studies of five members of one family were consistent with transmission of these hetermorphisms in codominant Mendelian fashion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maegenis, R E -- Donlon, T A -- Wyandt, H E -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):64-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694520" target="_blank"〉PubMed〈/a〉
Keywords:
Azure Stains
;
Centromere/ultrastructure
;
Chromosomes, Human, 1-3/*ultrastructure
;
Genes, Dominant
;
Heterochromatin/ultrastructure
;
Humans
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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