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  • 1
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    Abnormal Erythropoiesis in Microgravity. (2004)
    American Society of Hematology
    Details
    Publication Date: 2004-11-16
    Description: Humans and experimental animals subjected to microgravity, such as experienced during space flight, exhibit alterations in erythropoiesis, including changes in red blood cell morphology, survival and a reduction in red blood cell mass. Some of these alterations have been attributed to a disruption of normal in vivo erythropoietin physiology. However, human bone marrow cells grown on orbit showed a profound reduction in the number of erythroid cells, suggesting a cellular component. We now report the results of a study carried out on orbit on the International Space Station (ISS UF-1) in which an erythroid cell line was induced to differentiate. Rauscher murine erythroleukemia cells, a continuous cell line that can undergo erythropoietin (Epo)- or chemical-induced differentiation similar to normal erythropoiesis, were cultured for 6 days either in microgravity on board the ISS or on earth and then for 3 days in the absence or presence of 50 U Epo/ml or 0.7% dimethyl sulfoxide (DMSO). The cells were fixed, stored on orbit and returned to earth for study. Compared to ground-based controls, cells cultured in microgravity exhibited a greater degree of differentiation (hemoglobinization) (p
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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    PAPER CURRENT
  • 2
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    Biomedical Science and Technology on the International Space Station - Benefits for Humanity (Ciencia Y Tecnologia Biomedica En La Estacion Espacial Internacional - Beneficios Para La Humanidad) (2018)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The International Space Station is a unique laboratory for performing investigations that affect human health both in space and on Earth. During its time in orbit, the space station has enabled research that is providing a better understanding of many aspects of human health including aging, trauma, disease and environmental impacts. Driven by the need to support astronaut health, several biological and human physiological investigations have yielded important results that we on Earth can also benefit from. These results include new ways to mitigate bone loss, insights into bacterial behavior, and innovative wound-healing techniques. Advances in telemedicine, disease models, psychological stress response systems, nutrition and cell behavior are just a few more examples of the benefits that have been gained from applying studies in orbit to human health back on Earth.
    Keywords: Aerospace Medicine
    Type: JSC-E-DAA-TN58554 , Expo-Ciencias Latinoamericana ESI AMLAT 2018; Jul 02, 2018 - Jul 06, 2018; Antofagasta; Chile
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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