ISSN:
1434-193X
Keywords:
Flavonoids
;
Catechin
;
Isotopic labeling
;
Carbon 13
;
Total synthesis
;
French paradox
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
-Racemic 4-[13C]catechin 14 has been synthesized in ten steps starting from potassium [13C]cyanide. The intermediate chalcone 9 was formed by acylation of the benzylated phloroglucinol 7 with the caffeic acid synthon 6, using the trifluoroacetic mixed anhydride. The flavonoid skeleton was then obtained by previously described reactions such as the reduction of chalcone 9 and dihydroxylation of flavene 11. Such [13C]-labelled polyphenols should prove to be useful tools for human biological investigations.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
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