ISSN:
1434-193X
Keywords:
Asymmetric synthesis
;
Nitrogen heterocycles
;
Heterocycles
;
Pyrrolidines
;
Piperidines
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
---Chiral, nonracemic 2-substituted pyrrolidines and piperidines were prepared in high ee and moderate to good chemical yields in three steps from (R)-phenylglycinol and γ- or δ-chloroketones. The key step of the synthesis was the stereoselective reductive ring-opening of chiral bicyclic 1,3-oxazolidines prepared by condensation of (R)-phenylglycinol and the corresponding ketones.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
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