Publication Date:
1978-03-31
Description:
In otherwise profoundly akinetic rats that had been severely depleted of brain catecholamines, anticholinergic drugs caused excessive walking. The effect did not appear until 10 days after surgery and then increased with time, suggesting that a phenomenon analogous to denervation supersensitivity may be involved. If the animals walked into corners, they were unable to turn around or back out. Their gait (extremely short steps) was reminiscent of that of patients with Parkinson's disease. The results are consistent with a mutually antagonistic interaction between cholinergic and dopaminergic brain systems and emphasize certain complexities in this interaction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schallert, T -- Whishaw, I Q -- Ramirez, V D -- Teitelbaum, P -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1461-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/564552" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Atropine/*pharmacology/therapeutic use
;
Catalepsy/chemically induced/drug therapy
;
Gait
;
Humans
;
Hydroxydopamines/*pharmacology
;
Locomotion/*drug effects
;
Male
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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