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  • 1
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    Aminophylline increases cerebral metabolic rate and decreases anoxic survival in young mice (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: In weanling mice treated with pharmacologic doses of aminophylline, the concentrations of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in the brain increased 44 and 36 percent, respectively, and the cerebral metabolic rate was three times that in controls. In neonatal mice, therapeutic doses of aminophylline greatly decreased the rate of anoxic survival in vivo and the duration of gasping of the isolated head. The findings suggest caution in the use of this drug and other methylxanthines in hypoxic human newborns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thurston, J H -- Hauhard, R E -- Dirgo, J A -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):649-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/209541" target="_blank"〉PubMed〈/a〉
    Keywords: Adenine Nucleotides/metabolism ; Aminophylline/*pharmacology/therapeutic use ; Animals ; Anoxia/physiopathology ; Apnea/drug therapy ; Brain/drug effects/*metabolism ; Cheyne-Stokes Respiration/drug therapy ; Cyclic AMP/metabolism ; Energy Metabolism/*drug effects ; Glucose/metabolism ; Glucosephosphates/metabolism ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/drug therapy ; Mice
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Taurine: possible role in osmotic regulation of mammalian heart (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-12-18
    Description: It is well established that taurine plays an important role in the maintenance of intracellular osmolal concentration in marine invertebrates, teleosts, and amphibians. In fresh water, concentrations of taurine in body tissues decrease; in salt water, they increase. In this study with mice we found that during adaptation of these mammals to chronic hypernatremia, the taurine content of the heart increased; concentrations of other amino acids were unchanged or were decreased. Welty and his associated have shown that acute hyponatremia lowered the taurine concentration of rat heart. In concert, these data suggest that taurine also may serve as an osmotic agent in mammalian heart.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thurston, J H -- Hauhart, R E -- Naccarato, E F -- NB 06163/NB/NB NIH HHS/ -- NS 15660/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1373-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313699" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/*physiology ; Animals ; Heart/*physiology ; Mice ; Taurine/*physiology ; Water-Electrolyte Balance
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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