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  • 1
    Publication Date: 2015-06-06
    Description: Author(s): Sen Yang, L. V. Butov, B. D. Simons, K. L. Campman, and A. C. Gossard At low temperatures, indirect excitons formed at the in-plane electron-hole interface in a coupled-quantum-well structure undergo a spontaneous transition into a spatially modulated state. We report on the control of the instability wavelength, measurement of the dynamics of the exciton emission pat... [Phys. Rev. B 91, 245302] Published Wed Jun 03, 2015
    Keywords: Semiconductors II: surfaces, interfaces, microstructures, and related topics
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 2
    Publication Date: 2011-01-08
    Description: Author(s): S. Ejima, M. J. Bhaseen, M. Hohenadler, F. H. L. Essler, H. Fehske, and B. D. Simons We investigate the phase diagram of bosons interacting via Feshbach-resonant pairing interactions in a one-dimensional lattice. Using large scale density matrix renormalization group and field theory techniques we explore the atomic and molecular correlations in this low-dimensional setting. We prov... [Phys. Rev. Lett. 106, 015303] Published Fri Jan 07, 2011
    Keywords: Condensed Matter: Structure, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 3
    Publication Date: 2012-03-27
    Description: Author(s): M. J. Bhaseen, S. Ejima, F. H. L. Essler, H. Fehske, M. Hohenadler, and B. D. Simons We explore the zero-temperature phase diagram of bosons interacting via Feshbach resonant pairing interactions in one dimension. Using DMRG (density matrix renormalization group) and field theory techniques we characterize the phases and quantum phase transitions in this low-dimensional setting. We ... [Phys. Rev. A 85, 033636] Published Mon Mar 26, 2012
    Keywords: Matter waves and collective properties of cold atoms and molecules
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
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  • 4
    Publication Date: 2011-08-30
    Description: Author(s): M. J. Bhaseen, S. Ejima, M. Hohenadler, A. O. Silver, F. H. L. Essler, H. Fehske, and B. D. Simons We explore the Mott insulating state of single-band bosonic pairing Hamiltonians using analytical approaches and large-scale density matrix renormalization group calculations. We focus on the second Mott lobe which exhibits a magnetic quantum phase transition in the Ising universality class. We use ... [Phys. Rev. A 84, 023635] Published Mon Aug 29, 2011
    Keywords: Matter waves and collective properties of cold atoms and molecules
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
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  • 5
    Publication Date: 2012-01-18
    Description: Author(s): M. J. Bhaseen, J. Mayoh, B. D. Simons, and J. Keeling Motivated by experiments observing self-organization of cold atoms in optical cavities, we investigate the collective dynamics of the associated nonequilibrium Dicke model. The model displays a rich semiclassical phase diagram of long-time attractors including distinct superradiant fixed points, bis... [Phys. Rev. A 85, 013817] Published Tue Jan 17, 2012
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
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  • 6
    Publication Date: 2014-04-09
    Description: Author(s): J. Keeling, M. J. Bhaseen, and B. D. Simons Following the experimental realization of Dicke superradiance in Bose gases coupled to cavity light fields, we investigate the behavior of ultracold fermions in a transversely pumped cavity. We focus on the equilibrium phase diagram of spinless fermions coupled to a single cavity mode and establish ... [Phys. Rev. Lett. 112, 143002] Published Tue Apr 08, 2014
    Keywords: Atomic, Molecular, and Optical Physics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 7
    Publication Date: 2010-10-12
    Description: With the capacity for rapid self-renewal and regeneration, the intestinal epithelium is stereotypical of stem cell-supported tissues. Yet the pattern of stem cell turnover remains in question. Applying analytical methods from population dynamics and statistical physics to an inducible genetic labeling system, we showed that clone size distributions conform to a distinctive scaling behavior at short times. This result demonstrates that intestinal stem cells form an equipotent population in which the loss of a stem cell is compensated by the multiplication of a neighbor, leading to neutral drift dynamics in which clones expand and contract at random until they either take over the crypt or they are lost. Combined with long-term clonal fate data, we show that the rate of stem cell replacement is comparable to the cell division rate, implying that neutral drift and symmetrical cell divisions are central to stem cell homeostasis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lopez-Garcia, Carlos -- Klein, Allon M -- Simons, Benjamin D -- Winton, Douglas J -- G0800784/Medical Research Council/United Kingdom -- Cancer Research UK/United Kingdom -- New York, N.Y. -- Science. 2010 Nov 5;330(6005):822-5. doi: 10.1126/science.1196236. Epub 2010 Sep 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20929733" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; *Cell Division ; Cell Lineage ; Clone Cells/cytology ; Colon/cytology ; Homeostasis ; Intestinal Mucosa/*cytology ; Intestine, Small/cytology ; Mice ; Stem Cells/*cytology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2012-07-24
    Description: Diseases of the esophageal epithelium (EE), such as reflux esophagitis and cancer, are rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial. Here, we show that in mice, EE is maintained by a single population of cells that divide stochastically to generate proliferating and differentiating daughters with equal probability. In response to challenge with all-trans retinoic acid (atRA), the balance of daughter cell fate is unaltered, but the rate of cell division increases. However, after wounding, cells reversibly switch to producing an excess of proliferating daughters until the wound has closed. Such fate-switching enables a single progenitor population to both maintain and repair tissue without the need for a "reserve" slow-cycling stem cell pool.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527005/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527005/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doupe, David P -- Alcolea, Maria P -- Roshan, Amit -- Zhang, Gen -- Klein, Allon M -- Simons, Benjamin D -- Jones, Philip H -- 079249/Wellcome Trust/United Kingdom -- 092096/Wellcome Trust/United Kingdom -- G0601740/Medical Research Council/United Kingdom -- G0700600/1/National Centre for the Replacement, Refinement and Reduction of Animals in Research/United Kingdom -- G0800784/Medical Research Council/United Kingdom -- MC_U105370181/Medical Research Council/United Kingdom -- U.1053.00.010(70181)/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2012 Aug 31;337(6098):1091-3. doi: 10.1126/science.1218835. Epub 2012 Jul 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council (MRC) Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22821983" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomarkers/analysis ; Cell Differentiation/drug effects ; Cell Division/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Doxycycline/pharmacology ; Epithelial Cells/*physiology ; Epithelium/drug effects/metabolism/*physiology ; Esophagus/*cytology/*physiology ; Green Fluorescent Proteins/biosynthesis ; Histones/biosynthesis ; Mice ; Mice, Inbred C57BL ; Recombinant Fusion Proteins/biosynthesis ; *Regeneration ; Stem Cells/metabolism/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2013-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simons, Benjamin D -- 079249/Wellcome Trust/United Kingdom -- 092096/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2013 Oct 11;342(6155):203-4. doi: 10.1126/science.1245288.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, UK. bds10@cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24115430" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gastrointestinal Tract/*embryology/*ultrastructure ; Humans ; *Morphogenesis ; Muscle, Smooth/*embryology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2012-09-04
    Description: The skin interfollicular epidermis (IFE) is the first barrier against the external environment and its maintenance is critical for survival. Two seemingly opposite theories have been proposed to explain IFE homeostasis. One posits that IFE is maintained by long-lived slow-cycling stem cells that give rise to transit-amplifying cell progeny, whereas the other suggests that homeostasis is achieved by a single committed progenitor population that balances stochastic fate. Here we probe the cellular heterogeneity within the IFE using two different inducible Cre recombinase-oestrogen receptor constructs targeting IFE progenitors in mice. Quantitative analysis of clonal fate data and proliferation dynamics demonstrate the existence of two distinct proliferative cell compartments arranged in a hierarchy involving slow-cycling stem cells and committed progenitor cells. After wounding, only stem cells contribute substantially to the repair and long-term regeneration of the tissue, whereas committed progenitor cells make a limited contribution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mascre, Guilhem -- Dekoninck, Sophie -- Drogat, Benjamin -- Youssef, Khalil Kass -- Brohee, Sylvain -- Sotiropoulou, Panagiota A -- Simons, Benjamin D -- Blanpain, Cedric -- 079249/Wellcome Trust/United Kingdom -- 092096/Wellcome Trust/United Kingdom -- England -- Nature. 2012 Sep 13;489(7415):257-62. doi: 10.1038/nature11393.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Universite Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22940863" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Division ; Cell Lineage ; Cell Survival ; Clone Cells/cytology/metabolism ; Epidermis/*cytology ; Integrases/genetics/metabolism ; Keratin-14/genetics ; Mice ; Promoter Regions, Genetic/genetics ; Protein Precursors/genetics ; Receptors, Estrogen/genetics/metabolism ; Stem Cells/*cytology/metabolism ; Tail/cytology ; Wound Healing/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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